中国东北地区银莲花属植物的民族植物学用途、地理分布、植物化学、质量控制和药理学综述

摘要(中文译文)

本文综述了东北地区六种银莲花属植物的分布、植物化学和药理学方面的最新知识。我们的研究结果表明，这些物种主要分布在黑龙江、吉林和辽宁省的山区，具有明显的形态特征。共鉴定出267种化合物，主要是皂苷、挥发油和氨基酸。其中，raddeanoside R3是研究最多的皂苷，也是《中国药典》中Anemone raddeana Regel的关键质量控制标志物。药理研究表明，这些化合物具有显著的抗癌、抗炎、抗氧化和镇痛活性。值得注意的是，raddeanoside R3诱导骨肉瘤、胶质母细胞瘤、癌症和癌症细胞凋亡。尽管取得了这些进展，但还需要进一步的研究来阐明这些物种的抗风湿特性，并为所有六种物种建立全面的质量控制标准。

Abstract

This review synthesises current knowledge on the distribution, phytochemistry, and pharmacology of six L. species in Northeast China. Our findings indicate that these species are primarily distributed in the mountainous regions of Heilongjiang, Jilin, and Liaoning provinces, with distinct morphological traits. A total of 267 compounds have been identified, predominantly saponins, volatile oils, and amino acids. Among these, raddeanoside R3 is the most studied saponin and serves as a key quality control marker for Regel in the Chinese Pharmacopoeia. Pharmacological studies reveal that these compounds exhibit significant anti-cancer, anti-inflammatory, antioxidant, and analgesic activities. Notably, raddeanoside R3 induces apoptosis in osteosarcoma, glioblastoma, gastric cancer, and breast cancer cells. Despite these advances, further research is needed to elucidate the anti-rheumatic properties of these species and to establish comprehensive quality control standards for all six species.

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