致命病毒性肺炎死后检测和模拟病毒再激活的可视化
Post-Mortem Detection and Visualization of Mimivirus Reactivation in Fatal Viral Pneumonia.
摘要(中文译文)
Mimivirus是一种巨大的双链DNA病毒（1.2 Mbp），具有独特的类细菌特征，包括因表面纤维含肽聚糖而呈现革兰氏阳性染色反应。自2005年以来，该病毒已在肺炎患者的呼吸道分泌物中被检出，但由于其高度遗传变异性和检测困难，其临床意义仍存在争议。本研究旨在通过调查Mimivirus在人肺组织中的存在及其复制潜力，特别是探索其与致死性呼吸系统结局的关联，以阐明该病毒的病理学意义。研究对两个队列的肺组织样本进行了比较性尸检分析：死于致死性病毒性肺炎的患者队列，以及无肺部病理史对照组。已知Mimivirus可有效感染肺泡巨噬细胞，提示其可能作为肺部炎症和组织损伤的储存库。目前证据表明，它可能作为一种机会性病原体或共生体，尤其在免疫功能低下或危重患者中。通过系统筛查尸检样本，本研究旨在确定Mimivirus是致死性肺炎的主要致病因子，还是人类呼吸道的偶然寄居者。
Abstract
Mimivirus, a giant double-stranded DNA virus ($1.2$ Mbp), possesses unique bacteria-like features, including a Gram-positive staining reaction due to peptidoglycan-containing surface fibers. While detected in the respiratory secretions of pneumonia patients since 2005, its clinical role remains controversial due to high genetic variability and detection challenges. This study aims to clarify the pathological significance of Mimivirus by investigating its presence and replication potential in human lung tissue, specifically exploring its association with fatal respiratory outcomes. A comparative post-mortem analysis was conducted on lung tissue samples from two cohorts: patients who succumbed to lethal viral pneumonia and a control group with no history of pulmonary pathology. Mimivirus is known to productively infect alveolar macrophages, suggesting they may serve as a reservoir for lung inflammation and tissue damage. Current evidence suggests it may act as an opportunistic or commensal agent, particularly in immunocompromised or critically ill patients. By systematically screening autopsy samples, this research seeks to establish whether Mimivirus is a primary causative agent of fatal pneumonia or an incidental inhabitant of the human respiratory tract.
如何引用
AMA
Parandzem Khachatryan, Naira Karalyan, Anna Semerjyan, Marina Tatoyan, Hakob Davtyan, Arsham Yeremyan, et al. Post-Mortem Detection and Visualization of Mimivirus Reactivation in Fatal Viral Pneumonia.. Viruses. 2026; doi:10.3390/v18030379.
APA
Parandzem Khachatryan, Naira Karalyan, Anna Semerjyan, Marina Tatoyan, Hakob Davtyan, Arsham Yeremyan, et al (2026). Post-Mortem Detection and Visualization of Mimivirus Reactivation in Fatal Viral Pneumonia.. Viruses. https://doi.org/10.3390/v18030379
GB/T 7714
Parandzem Khachatryan, Naira Karalyan, Anna Semerjyan, Marina Tatoyan, Hakob Davtyan, Arsham Yeremyan, et al. Post-Mortem Detection and Visualization of Mimivirus Reactivation in Fatal Viral Pneumonia.[J]. Viruses, 2026 doi:10.3390/v18030379.
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