年轻成年女性宫颈和阴道原位胃型腺癌的同步表现：一种罕见的前兆
Synchronous Presentation of Gastric-Type Adenocarcinoma In Situ of Cervix and Vagina in a Young Adult Female: A Precursor Seldom Seen.
摘要(中文译文)
同步性人乳头瘤病毒非依赖性胃型原位腺癌同时累及宫颈和阴道上皮是一种极为罕见的浸润前病变。其诊断复杂性源于无症状表现以及跳跃性病变，后者掩盖了疾病的真实范围。我们报告一例26岁女性，在常规宫颈癌筛查中发现非典型腺细胞。连续多次宫颈锥切术均一致显示胃型原位腺癌，且手术切缘持续阳性。锥切术后阴道镜评估及组织病理学检查显示广泛的多灶性疾病，累及残留宫颈和阴道。考虑到疾病负担较重及潜在隐匿性浸润的可能，遂行手术干预，包括B1型根治性子宫切除术、双侧输卵管切除术、双侧卵巢组织冷冻保存、全阴道切除术及阴道重建术。随访20个月，患者完全无病生存，无复发证据。
Abstract
Synchronous human papillomavirus-independent gastric-type adenocarcinoma in situ affecting both cervical and vaginal epithelium constitutes an ultrarare preinvasive disease. The diagnostic complexity arises from asymptomatic presentation and skip lesions that obscure the true extent of the disease. We report the case of a 26-year-old woman diagnosed with atypical glandular cells during routine cervical cancer screening. Sequential conizations consistently demonstrated gastric-type adenocarcinoma in situ with persistently positive surgical margins. Post-conization colposcopic assessment and histopathology revealed extensive multifocal disease involving residual cervix and vaginum. Considering the substantial disease burden and potential for occult invasion, surgical intervention was undertaken, including type B1 radical hysterectomy, bilateral salpingectomy, bilateral ovarian tissue cryopreservation, total vaginectomy, and vaginal reconstruction. At 20 months of follow-up, the patient remains completely disease-free with no evidence of recurrence.
如何引用
AMA
Sholanki Halder, Suvidya Singh, Ridhi Sood, Sandeep Mathur, Smita Manchanda, Neena Malhotra, et al. Synchronous Presentation of Gastric-Type Adenocarcinoma In Situ of Cervix and Vagina in a Young Adult Female: A Precursor Seldom Seen.. The journal of obstetrics and gynaecology research. 2026; doi:10.1111/jog.70249.
APA
Sholanki Halder, Suvidya Singh, Ridhi Sood, Sandeep Mathur, Smita Manchanda, Neena Malhotra, et al (2026). Synchronous Presentation of Gastric-Type Adenocarcinoma In Situ of Cervix and Vagina in a Young Adult Female: A Precursor Seldom Seen.. The journal of obstetrics and gynaecology research. https://doi.org/10.1111/jog.70249
GB/T 7714
Sholanki Halder, Suvidya Singh, Ridhi Sood, Sandeep Mathur, Smita Manchanda, Neena Malhotra, et al. Synchronous Presentation of Gastric-Type Adenocarcinoma In Situ of Cervix and Vagina in a Young Adult Female: A Precursor Seldom Seen.[J]. The journal of obstetrics and gynaecology research, 2026 doi:10.1111/jog.70249.
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