病例报告：膜性/细胞质性Ki-67染色与PAX8-GLIS3融合：界定透明化小梁肿瘤的临床病理谱以优化患者管理
Case Report: Membranous/cytoplasmic Ki-67 staining and PAX8-GLIS3 fusion: defining the clinicopathological spectrum of hyalinizing trabecular tumor to optimize patient management.
摘要(中文译文)
玻璃样变梁状肿瘤（HTT）是一种罕见的甲状腺肿瘤，预后极佳，但其形态学上与甲状腺乳头状癌（PTC）等恶性肿瘤相似，常导致诊断困难。为明确HTT的临床病理、免疫组化和分子特征，本研究分析了21例HTT病例和10例PTC病例，并结合文献复习对研究结果进行补充。HTT队列包括18例女性和3例男性患者，平均年龄51岁。细胞学上，HTT可通过其独特的膜性/胞质性Ki-67染色模式、基因融合的存在以及偶见的多倍体细胞与PTC相鉴别。组织学上，肿瘤边界清楚，呈梁状或器官样生长，胞质嗜酸性至颗粒状，可见核旁黄色包涵体及玻璃样变间质。免疫组化方面，HTT一致表达TG、TTF1和CD56，而Ki-67呈独特的膜性/胞质性分布。分子谱分析未发现、或突变。然而，所有HTT病例均检测到融合，而PTC中未见此发现。在细胞学标本上进行Ki-67免疫组化或检测有助于明确诊断并避免不必要的手术。因此，整合细胞学、组织学、免疫组化和分子数据的综合方法对于HTT的准确诊断和最佳临床管理至关重要。
Abstract
Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with an excellent prognosis, yet its morphological resemblance to malignancies such as papillary thyroid carcinoma (PTC) often complicates its diagnosis. To characterize the clinicopathological, immunohistochemical, and molecular profiles of HTT, this study analyzed 21 HTT cases and 10 PTC cases, and the findings were supplemented by a literature review. The HTT cohort included 18 female and 3 male patients, with a mean age of 51 years. Cytologically, HTT can be distinguished from PTC by its distinctive membranous/cytoplasmic Ki-67 staining pattern and the presence of the gene fusion and occasional polyploid cells. Histologically, the tumors were well-demarcated and exhibited trabecular or organoid growth, eosinophilic to granular cytoplasm, paranuclear yellow inclusions, and hyalinized stroma. Immunohistochemically, HTT consistently expressed TG, TTF1, and CD56, while Ki-67 showed a unique membranous/cytoplasmic distribution. Molecular profiling identified no , , , or mutations. However, fusion was detected in all HTT cases, a finding absent from PTC. The use of Ki-67 immunohistochemistry or testing on cytological specimens can aid in definitive diagnosis and prevent unnecessary surgery. Thus, an integrated approach combining cytological, histological, immunohistochemical, and molecular data is essential for the accurate diagnosis and optimal clinical management of HTT.
如何引用
AMA
Haining Huang, Ran Zhao, Liman Zhang, Shujun Ren, Jianli Liu, Dandan Yang, et al. Case Report: Membranous/cytoplasmic Ki-67 staining and PAX8-GLIS3 fusion: defining the clinicopathological spectrum of hyalinizing trabecular tumor to optimize patient management.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1764079.
APA
Haining Huang, Ran Zhao, Liman Zhang, Shujun Ren, Jianli Liu, Dandan Yang, et al (2026). Case Report: Membranous/cytoplasmic Ki-67 staining and PAX8-GLIS3 fusion: defining the clinicopathological spectrum of hyalinizing trabecular tumor to optimize patient management.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1764079
GB/T 7714
Haining Huang, Ran Zhao, Liman Zhang, Shujun Ren, Jianli Liu, Dandan Yang, et al. Case Report: Membranous/cytoplasmic Ki-67 staining and PAX8-GLIS3 fusion: defining the clinicopathological spectrum of hyalinizing trabecular tumor to optimize patient management.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1764079.
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