CDC20对肺腺癌恶性胸腔积液的诊断价值
The diagnostic value of CDC20 for malignant pleural effusion of lung adenocarcinoma.
摘要(中文译文)
肺腺癌(LUAD)具有早期发现困难、肿瘤进展迅速、晚期手术切除率低的特点。肺腺癌患者常见的并发症是恶性胸腔积液(MPE)。与肺活检相比，胸腔积液脱落细胞学检查是一种侵入性较小的操作。因此，迫切需要发现新的、有效的肺腺癌胸腔积液脱落细胞学标志物。本研究以Gepia数据库中肺腺癌肿瘤与癌旁组织的差异表达基因为切入点，筛选出细胞分裂周期蛋白20(CDC20)作为肺腺癌的新生物标志物。分析了92例肺腺癌及癌旁正常组织中CDC20、TTF-1和NapsinA的表达水平，并对30例肺腺癌和30例非肿瘤患者胸腔积液的石蜡标本进行了免疫组化检测。免疫组化结果显示，在92例观察组中，CDC20在肺腺癌组织中表达较高，且与肿瘤大小、T分期和胸膜侵犯相关。本研究结果表明，CDC20在肺腺癌和恶性胸腔积液中的表达与TTF-1和NapsinA较为一致。本研究揭示了CDC20在肺腺癌活检标本和胸腔积液中的潜在诊断价值。我们的发现对胸腔积液细胞学的病理诊断具有重要意义。
Abstract
Lung adenocarcinoma (LUAD) is characterized by difficult early detection, rapid tumor progression and low surgical resection rate in the late stage. The common complication of patients with lung adenocarcinoma is malignant pleural effusion (MPE). Compared with lung biopsy, cytological examination of exfoliated pleural effusion is a less invasive operation. Therefore, there is an urgent need to discover new and effective cytological biomarkers for the exfoliation of LUAD pleural effusion. This work took the differentially expressed genes of LUAD tumors and adjacent tissues in the Gepia database as the entry point and screened out Cell division cycle protein 20 (CDC20) as a new biomarker for lung adenocarcinoma. The expression levels of CDC20, TTF-1 and NapsinA in 92 cases of lung adenocarcinoma and adjacent normal tissues were analyzed, and immunohistochemical detection was performed on paraffin specimens of pleural effusion from 30 cases of lung adenocarcinoma and 30 cases of non-neoplastic patients. Immunohistochemistry indicated that CDC20 was more expressed in LUAD tissues in the 92 observation groups and was related to tumor size, T classification, and pleural invasion. In this study, the results showed the expression of CDC20 was relatively consistent with that of TTF-1 and NapsinA in LUAD and malignant pleural effusion. This study reveals the potential diagnostic value of CDC20 in biopsy specimens of LUAD and pleural effusion. Our discovery is of great significance for the pathological diagnosis of pleural effusion cytology.
如何引用
AMA
Yulan Liu, Liping Wu, Jinrong Chen, Yinghong Yu, Shigao Chen, Jie Hu, et al. The diagnostic value of CDC20 for malignant pleural effusion of lung adenocarcinoma.. Scientific reports. 2026; doi:10.1038/s41598-026-41506-2.
APA
Yulan Liu, Liping Wu, Jinrong Chen, Yinghong Yu, Shigao Chen, Jie Hu, et al (2026). The diagnostic value of CDC20 for malignant pleural effusion of lung adenocarcinoma.. Scientific reports. https://doi.org/10.1038/s41598-026-41506-2
GB/T 7714
Yulan Liu, Liping Wu, Jinrong Chen, Yinghong Yu, Shigao Chen, Jie Hu, et al. The diagnostic value of CDC20 for malignant pleural effusion of lung adenocarcinoma.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-41506-2.
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