超声激活的仿生纳米平台能够实现对前列腺癌症和淋巴转移的长效化学单动力治疗
Ultrasound-activated biomimetic nanoplatform enables long-acting chemo-sonodynamic therapy of prostate cancer and lymphatic metastasis.
摘要(中文译文)
前列腺癌伴淋巴转移的有效治疗仍受限于药物在原发性肿瘤和转移性淋巴结中滞留不足以及缺乏可控暴露。在此，我们报道了一种仿生、还原响应和超声响应的中空介孔二氧化硅纳米平台（HMSN@TCM/Ce6），可在肿瘤和淋巴部位实现长效、时空调控的化学-声动力治疗。该系统由还原敏感性中空二氧化硅核心包载10-羟基喜树碱（HCPT）以及嵌入二氢卟吩e6（Ce6）的肿瘤细胞膜（TCM）外壳组成。这种层级设计将瘤内持续滞留、同源靶向和外部触发的声动力激活整合于单一平台中。仿生TCM涂层延长了全身循环时间并促进肿瘤优先蓄积，而中空二氧化硅核心则作为氧化还原响应性HCPT释放的长期储库。在超声照射下，局部活性氧（ROS）生成诱导瞬时膜扰动，从而加速纳米颗粒内吞和按需载荷释放。重要的是，超声增强的肿瘤滞留进一步促进纳米颗粒向肿瘤引流淋巴结再分布，建立了多阶段肿瘤至淋巴结的治疗接力，从而实现二次药物蓄积和细胞毒性。全面的体外和体内评价表明，该平台具有延长的药代动力学、升高的肿瘤和淋巴结蓄积，以及有效抑制原发肿瘤和转移性淋巴结的效果，同时保持良好的生物安全性。超越传统的缓释储库，本工作引入了一种外部可控的长效递送范式，其中单次全身给药形成序贯的、位点特异性的治疗储库。该策略为智能长效纳米药物提供了一个通用框架，具有用于精准和微创癌症治疗的潜力。
Abstract
The effective treatment of prostate cancer with lymphatic metastasis remains limited by insufficient drug retention and the lack of controllable exposure in both primary tumors and metastatic lymph nodes. Here, we report a biomimetic, reduction- and ultrasound-responsive hollow mesoporous silica nanoplatform (HMSN@TCM/Ce6) that enables long-acting, spatiotemporally regulated chemo-sonodynamic therapy across tumor and lymphatic sites. The system comprises a reduction-sensitive hollow silica core encapsulating 10-hydroxycamptothecin (HCPT) and a tumor cell membrane (TCM) shell embedding chlorin e6 (Ce6). This hierarchical design integrates sustained intratumoral retention, homologous targeting, and externally triggered sonodynamic activation within a single platform. The biomimetic TCM coating prolongs systemic circulation and facilitates preferential tumor accumulation, while the hollow silica core functions as a long-term reservoir for redox-responsive HCPT release. Upon ultrasound irradiation, localized ROS generation induces transient membrane perturbation, which accelerates nanoparticle internalization and on-demand payload release. Importantly, ultrasound-enhanced tumor retention further promotes nanoparticle redistribution toward tumor-draining lymph nodes, establishing a multistage tumor-to-lymph node therapeutic relay that enables secondary drug accumulation and cytotoxicity. Comprehensive in vitro and in vivo evaluations demonstrate prolonged pharmacokinetics, elevated tumor and lymph node accumulation, and effective inhibition of both primary tumors and metastatic lymph nodes, while maintaining favorable biosafety. Beyond conventional sustained-release depots, this work introduces an externally controllable long-acting delivery paradigm in which a single systemic dose forms sequential, site-specific therapeutic depots. This strategy provides a versatile framework for intelligent long-acting nanomedicines with potential for precision and minimally invasive cancer therapy.
如何引用
AMA
Hui Guo, Lei Chen, Kai Yu, Jixue Wang. Ultrasound-activated biomimetic nanoplatform enables long-acting chemo-sonodynamic therapy of prostate cancer and lymphatic metastasis.. Colloids and surfaces. B, Biointerfaces. 2026; doi:10.1016/j.colsurfb.2026.115578.
APA
Hui Guo, Lei Chen, Kai Yu, Jixue Wang (2026). Ultrasound-activated biomimetic nanoplatform enables long-acting chemo-sonodynamic therapy of prostate cancer and lymphatic metastasis.. Colloids and surfaces. B, Biointerfaces. https://doi.org/10.1016/j.colsurfb.2026.115578
GB/T 7714
Hui Guo, Lei Chen, Kai Yu, Jixue Wang. Ultrasound-activated biomimetic nanoplatform enables long-acting chemo-sonodynamic therapy of prostate cancer and lymphatic metastasis.[J]. Colloids and surfaces. B, Biointerfaces, 2026 doi:10.1016/j.colsurfb.2026.115578.
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