{“_”：“热处理菌株调节犬骨关节炎相关系统的炎症和代谢过程。”，“i”：[“鼠李糖乳酸杆菌”，“体外”]}
{"_":"Heat-Treated Strains Modulate Inflammatory and Metabolic Processes in Systems Relevant to Canine Osteoarthritis.","i":["Lacticaseibacillus rhamnosus","In Vitro"]}
摘要(中文译文)
犬骨关节炎是一种进行性退行性关节疾病，以炎症、结构损伤、疼痛和关节功能受损为特征。骨关节炎的风险不仅受年龄、遗传、肥胖和潜在关节病等公认因素的影响，还受低度炎症和肌肉减少症等全身性状况的影响。尽管近期已有兽医指南，当前干预措施主要侧重于缓解疼痛，而非减轻生理功能损害。本研究采用多种临床前模型，以筛选具有促进犬关节健康潜力的后生元候选物。对九株热处理细菌菌株的初步筛选鉴定出两株菌株——PRIOME JH和HT-PB01，它们在犬软骨细胞上表现出显著的抗炎活性。进一步表征显示，这两株菌株可显著增加犬软骨细胞中II型胶原的合成，并调节犬巨噬细胞的免疫反应，使白细胞介素-10的分泌相对于白细胞介素-12增加。此外，两株菌株在模型中均显示出减轻肠道炎症和通透性、脂肪堆积及肌肉减少症等风险因素的潜力。总之，本研究鉴定出两个有前景的后生元候选物——PRIOME JH和HT-PB01，它们具有通过多因素机制靶向骨关节炎相关关键风险因素的潜力。这些发现强调有必要开展犬临床试验，以评估其在骨关节炎中的相关性。
Abstract
Canine osteoarthritis is a progressive degenerative joint condition characterized by inflammation, structural damage, pain, and impaired joint function. Osteoarthritis risk is influenced not only by well-established factors such as age, genetics, obesity and underlying arthropathies, but also by systemic conditions such as low-grade inflammation and sarcopenia. Current interventions are primarily focused on pain relief rather than mitigating physiological impairment, despite recent veterinary guidelines. In this study, several preclinical models were employed to identify postbiotic candidates with potential to promote canine joint health. An initial screening of nine heat-treated bacterial strains identified two strains, PRIOME JH and HT-PB01, which demonstrated significant anti-inflammatory activity on canine chondrocytes. Further characterization revealed that these two strains significantly increased type II collagen synthesis in canine chondrocytes and modulate immune responses in canine macrophages, enhancing Interleukin-10 secretion over Interleukin-12. Additionally, both strains showed potential in mitigating risk factors such as gut inflammation and permeability, fat accumulation and sarcopenia in models. In conclusion, this study identified two promising postbiotic candidates, PRIOME JH and HT-PB01, with the potential to target key risk factors associated with osteoarthritis through multifactorial mechanisms. These findings emphasize conducting dog clinical trials to evaluate their relevance in osteoarthritis.
如何引用
AMA
Laura Rago, Guillermo García-Lainez, Miren Maicas, Ester Pardo, Veronica Navarro, Jennifer Redondo, et al. {"_":"Heat-Treated Strains Modulate Inflammatory and Metabolic Processes in Systems Relevant to Canine Osteoarthritis.","i":["Lacticaseibacillus rhamnosus","In Vitro"]}. Cells. 2026; doi:10.3390/cells15040336.
APA
Laura Rago, Guillermo García-Lainez, Miren Maicas, Ester Pardo, Veronica Navarro, Jennifer Redondo, et al (2026). {"_":"Heat-Treated Strains Modulate Inflammatory and Metabolic Processes in Systems Relevant to Canine Osteoarthritis.","i":["Lacticaseibacillus rhamnosus","In Vitro"]}. Cells. https://doi.org/10.3390/cells15040336
GB/T 7714
Laura Rago, Guillermo García-Lainez, Miren Maicas, Ester Pardo, Veronica Navarro, Jennifer Redondo, et al. {"_":"Heat-Treated Strains Modulate Inflammatory and Metabolic Processes in Systems Relevant to Canine Osteoarthritis.","i":["Lacticaseibacillus rhamnosus","In Vitro"]}[J]. Cells, 2026 doi:10.3390/cells15040336.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出