miRNA作为脊髓损伤神经元修复与再生的有前景的转化策略
MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury.
摘要(中文译文)
脊髓损伤（SCI）是对中枢神经系统（CNS）的一种毁灭性损伤，可导致SCI患者运动能力和感觉功能受损。SCI的特征包括神经炎症、轴突变性、神经元丢失和反应性胶质增生。目前的治疗策略，包括干细胞移植，尚未实现成功的临床治疗。miRNA在中枢神经系统发育过程中神经细胞类型的分化以及包括SCI在内的神经损伤后的病理过程中至关重要。这使其成为该病症治疗的理想候选者。事实上，多项研究已证明在中枢神经系统损伤中差异表达的miRNA参与其中。在此背景下，本综述的目的是概述评估miRNA疗法用于SCI的临床前证据。具体而言，我们将注意力集中在与神经元和轴突再生广泛相关的miRNA上。“miRNA替代疗法”旨在将miRNA递送至病变细胞并提高其在细胞中的靶向效率，这一新的治疗工具可能为促进SCI修复和减少功能缺损提供一种有前景的技术。
Abstract
Spinal cord injury (SCI) represents a devastating injury to the central nervous system (CNS) that is responsible for impaired mobility and sensory function in SCI patients. The hallmarks of SCI include neuroinflammation, axonal degeneration, neuronal loss, and reactive gliosis. Current strategies, including stem cell transplantation, have not led to successful clinical therapy. MiRNAs are crucial for the differentiation of neural cell types during CNS development, as well as for pathological processes after neural injury including SCI. This makes them ideal candidates for therapy in this condition. Indeed, several studies have demonstrated the involvement of miRNAs that are expressed differently in CNS injury. In this context, the purpose of the review is to provide an overview of the pre-clinical evidence evaluating the use of miRNA therapy in SCI. Specifically, we have focused our attention on miRNAs that are widely associated with neuronal and axon regeneration. "MiRNA replacement therapy" aims to transfer miRNAs to diseased cells and improve targeting efficacy in the cells, and this new therapeutic tool could provide a promising technique to promote SCI repair and reduce functional deficits.
如何引用
AMA
Serena Silvestro, Emanuela Mazzon. MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury.. Cells. 2022; doi:10.3390/cells11142177.
APA
Serena Silvestro, Emanuela Mazzon (2022). MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury.. Cells. https://doi.org/10.3390/cells11142177
GB/T 7714
Serena Silvestro, Emanuela Mazzon. MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury.[J]. Cells, 2022 doi:10.3390/cells11142177.
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