关于脂肪细胞因子在非酒精性脂肪性肝病发病机制中的作用及其与肝细胞因子关联的最新研究进展

摘要(中文译文)

非酒精性脂肪性肝病（NAFLD）目前被认为是全球慢性肝病的主要原因。导致该病发生和进展的机制是研究人员和临床医生极为关注的主题。当前的多重打击假说使肝脏与脂肪组织之间的交互作用成为关注焦点。众所周知，脂肪组织产生循环因子，即脂肪细胞因子，这些因子对肝细胞产生多种效应，促进肥胖个体中NAFLD的发生及其向非酒精性脂肪性肝炎的进展。类似地，肝细胞也可能通过产生和释放肝因子进入循环来响应致肥胖刺激。在此，作者概述了关于最相关的脂肪细胞因子和肝因子在NAFLD发病机制中作用的最新研究进展，并着重介绍了它们可能的分子和功能相互作用。

Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently considered the main cause of chronic liver disease worldwide. Mechanisms leading to the development and progression of this disease are topics of great interest for researchers and clinicians. The current multi-hit hypothesis has thrown the crosstalk between liver and adipose tissue into sharp focus. It is well known that adipose tissue produces circulating factors, known as adipocytokines, which exert several effects on liver cells, promoting the onset of NAFLD and its progression to non-alcoholic steatohepatitis in obese subjects. In a similar way, hepatocytes may also respond to obesogenic stimuli by producing and releasing hepatokines into the circulation. Here, the authors provide an overview of recent advances in our understanding of the role of the most relevant adipocytokines and hepatokines in NAFLD pathogenesis, highlighting their possible molecular and functional interactions.

如何引用

Expert review of gastroenterology & hepatology 的其他文献

• HIV感染者的非酒精性脂肪肝和脂肪性肝炎