光化性角化病 Actinic keratosis - PubMed 文献(第 4 页)
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光化性角化病 的 PubMed 搜索结果(第 4 页)
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Clarifying Progress on the Genomic Landscape of Actinic Keratosis. 阐明光化性角化病基因组图景的进展。
Most cutaneous squamous cell carcinomas (cSCCs) arise from actinic keratoses (AKs), making these premalignant lesions attractive targets for therapeutic intervention before transformation. In a new article of the Journal of Investigative Dermatology, Thomson et al. (2021) characterize the genetic alterations in AKs and identify significantly mutated drivers associated with risk factors such as UVR or azathioprine along with signaling pathways that may regulate the progression from AK to cSCC.
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A multicenter retrospective analysis of the clinical and pathological characteristics of 1188 cases of actinic keratosis in different ultraviolet radiation intensity areas of China. 中国不同紫外线辐射强度地区1188例光化性角化病临床和病理特征的多中心回顾性分析。
Actinic keratosis (AK) is a precancerous disease, caused by ultraviolet radiation (UV). To analyze the clinical and pathological characteristics of AK in four areas with different ultraviolet radiation intensities. 1188 diagnosed AK patients, from January 2000 to July 2015, in dermatology department of four hospitals were collected. The UV intensity of hospital located cities from high to low is Kunming, Yinchuan, Shenyang and Nanjing. The information comes from medical records, and the pathological types and Keratinocyte Intraepithelial Neoplasia (KIN) grades were checked by two experienced pathologists. All information was conducted a retrospective multicenter research. The patients were mainly middle-aged and elderly female, which was in direct contrast to the majority of men in European. The age of onset in Kunming group was lower than that in Yinchuan Group (p = 0.013) and Nanjing Group (p < 0.01). The course of disease in Kunming group was significantly shorter than that in Nanjing Group (p < 0.001). The lesions were almost located in the exposed area. The proportion of unexposed areas in Shenyang group was significantly higher than that in other groups (p < 0.001). There were statistical differences in pathological morphological classification among the four groups. These differences were not affected by age and gender. The number of KIN III grade patients in Shenyang group was significantly higher than that in other three groups (p < 0.05). The Asian patients were mainly female. The clinical characteristics of AK are closely related to UV intensity, and environmental pollution, lifestyle, religious beliefs and other factors are also related.
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Skin cancer and actinic keratosis in people with albinism: a systematic review and meta-analysis. 白化病患者中的皮肤癌和光化性角化病：系统评价和荟萃分析。
People with albinism, a genetic condition characterized by reduced melanin production, have an increased risk of developing skin cancer due to their diminished photoprotection. The global prevalence of albinism is estimated at 1 in 17,000 individuals, but it varies significantly by region, being more common in certain parts of Africa. Despite this heightened vulnerability, data on the prevalence of skin cancer and its subtypes in this population remain limited. This study aimed to determine the prevalence of Skin Cancer (SC) and Actinic Keratosis (AK) among patients with albinism. A systematic search of PubMed, Embase, Web of Science, and Cochrane databases was conducted, only including cross-sectional and cohort studies. The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Statistical analyses were performed using R software, and heterogeneity was assessed via the I statistic. Among 1,747 individuals with albinism from 12 studies, the pooled prevalence of actinic keratosis (AK) was 38% (95% CI 17.7-60.3; I = 99%), and that of skin cancer (SC) was 19% (95% CI 13.5-24.4; I = 89%). Within the SC group, squamous cell carcinoma (SCC) accounted for 55.4% (95% CI 36.2-73.8; I = 94%), basal cell carcinoma (BCC) for 33.7% (95% CI 19.6-49.2; I = 91%), and malignant melanoma (MM) for 0% (95% CI 0.00-0.56; I = 0%). The results show persistent heterogeneity driven by differences in study design, diagnostic criteria, and the predominance of cross-sectional data. Future research should aim to address these gaps by employing longitudinal designs, standardizing diagnostic criteria, and including detailed patient-level data. This study demonstrates a high global prevalence of actinic keratosis (AC) and skin cancer (SC) among individuals with albinism, reinforcing the need for targeted surveillance, preventive strategies, and treatments tailored to this high-risk population. Overall, heterogeneity remained high across outcomes despite the exclusion of individual studies.
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Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil. 巴西圣保罗州包鲁市日裔巴西人中癌前皮肤病变和非黑色素瘤皮肤癌的患病率。
Precancerous lesions and skin cancer are infrequent in Asians, and have received little documentation in the literature. Brazil has the world's largest contingent of Japanese immigrants and their descendants, and 70% live in the State of São Paulo. The prevalence of such skin lesions in Japanese-Brazilians is unknown. This study aimed to assess the prevalence of actinic keratoses and non-melanoma skin cancer in first and second-generation Japanese-Brazilians over 30 years of age, without miscegenation, living in the city of Bauru, São Paulo State, in 2006. Of the 567 Japanese-Brazilians that underwent dermatological examination, actinic keratosis was diagnosed in 76, with a mean age of 68.9 years, and a single case of basal cell carcinoma was detected in a 39-year-old female patient. In Japan, prevalence of actinic keratosis varies from 0.76% to 5%, and the incidence of non-melanoma skin cancer is 1.2 to 5.4/100 thousand. Japanese-Brazilians from Bauru showed a 13.4% prevalence of actinic keratoses and earlier age at onset. Proximity to the Equator and a history of farming contribute to these higher rates. Presence of solar melanosis was associated with a 1.9-fold risk of developing actinic keratosis.
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Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5. 通过抑制环氧化酶-2治疗光化性角化病：3%双氯芬酸钠在2.5%透明质酸中的潜在作用机制。
Cyclooxygenase-2 (COX-2) and its metabolic product prostaglandin E (PGE ) are induced in response to growth factors, inflammatory cytokines, tumor promoters, activated oncogenes, and, in the skin, ultraviolet (UV) radiation. Accumulating evidence suggests a role for the COX-2/PGE pathway in tumorigenesis in various tissue types including cutaneous squamous cell carcinoma. There is also strong evidence for a role in the development of actinic keratoses (AKs) - common dysplastic lesions of the skin associated with UV radiation overexposure - considered as part of a continuum with skin cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) exert their anti-inflammatory, analgesic, and antipyretic effects by reversibly or irreversibly acetylating COX isoforms, inhibiting downstream prostaglandins, and may have a chemopreventive role in malignancies, including skin cancer. Topical treatment of AK lesions with the NSAID diclofenac sodium 3% in combination with hyaluronic acid 2.5% has been shown to be effective and well tolerated, although the mechanism of action remains to be elucidated.
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[Line-field confocal optical coherence tomography and artificial intelligence]. [线场共焦光学相干断层扫描和人工智能]。
The diagnosis of actinic keratosis (AK), basal cell carcinoma (BCC), and psoriasis may present a challenge in everyday dermatological practice. Clinical and dermoscopic assessments often reach their limits, especially in ambiguous or anatomically difficult-to-access lesions. Biopsies are often impractical, and objective tools for treatment monitoring are lacking. To investigate the potential of line-field confocal optical coherence tomography (LC-OCT) combined with artificial intelligence (AI) for noninvasive diagnosis, differentiation, and longitudinal monitoring. Analysis and evaluation of LC-OCT imaging data from various studies. Application of AI-based algorithms for the detection of vascular patterns, epidermal changes, and BCC identification using heatmap-supported decision tools. The LC-OCT enables high-resolution, real-time visualization of dermoepidermal structures as well as vascular architecture. In combination with AI, objective parameters such as PRO score, atypia, and vascular morphology can be quantified and monitored over time. AI-assisted diagnostics significantly improve diagnostic accuracy-especially in BCC and among less experienced users. However, implementation requires clear guidelines, standardization, and well-defined legal and ethical frameworks. The LC-OCT combined with AI is a promising tool for more precise, standardized, and personalized dermatological diagnostics. Particularly in AK, BCC, and psoriasis, it has the potential to enhance care, reduce the need for invasive procedures, and provide novel insights into tumor and inflammation biology.
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Diagnostic utility and comparative immunohistochemical analysis of MITF-1 and SOX10 to distinguish melanoma in situ and actinic keratosis: a clinicopathological and immunohistochemical study of 70 cases. MITF-1和SOX10在区分原位黑色素瘤和光化性角化病中的诊断效用及比较免疫组织化学分析：70例的临床病理和免疫组织化学研究。
The histologic assessment of intraepidermal melanocytic proliferations involving sun-damaged skin may be challenging in scant biopsy material. Melanoma in situ may occasionally be confused with intraepidermal melanocytic hyperplasia on sun-damaged skin; thus, dermatopathologists may use immunohistochemical studies to help distinguish these entities. Historically, melanoma antigen recognized by T-cells 1 (MART-1) has been regarded as a valuable stain to confirm intraepidermal melanocytes; however, MART-1 may overestimate the number of melanocytes because it labels the melanoma dendrites and might also label pigmented keratinocytes, including structures mimicking junctional melanocytic nests in the setting of a lichenoid infiltrate. A total of 70 cases were retrospectively chosen, including 50 cases of melanoma in situ and 20 cases of actinic keratoses. SOX10 and microphthalmia transcription factor 1 (MITF-1) were performed in all cases. In all cases, the number of cells within epidermis that were identified as melanocytes by immunohistochemistry was compared with the number of melanocytes observed by morphology on hematoxylin and eosin sections. All cases of melanoma in situ showed expression of SOX10; however, the proportion of atypical melanocytes showing strong nuclear positivity was variable and did not approach that seen in MITF-1. There was no expression of either MITF-1 or SOX10 in adjacent pigmented keratinocytes in the cases of actinic keratoses. Both MITF-1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with melanocytic hyperplasia; however, MITF-1 exhibits slight superior sensitivity and seems to be a more effective immunostain than SOX10 for the identification and quantification of melanocytes in the setting of melanoma in situ, especially in cases where there is limited tissue.
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Harmonisation of Outcome Parameters and Evaluation (HOPE) for actinic keratosis: protocol for the development of a core outcome set. 光化性角化病结局参数和评估的统一（HOPE）：核心结局集开发方案。
Actinic keratoses (AK) are common skin lesions that can progress to invasive squamous cell carcinoma of the skin. A variety of lesion- or field-targeted treatment options exist and their efficacy has been demonstrated in numerous randomised controlled trials (RCTs). However, the reported endpoints are highly heterogeneous, making it difficult to assess and compare distinct treatment options and to reach an evidence-based choice of therapy. A systematic literature search will be conducted to analyse which endpoints are reported in RCTs. The focus will be on effectiveness, tolerability, cosmesis, and patient satisfaction. The reported endpoints of these studies, as well as their frequency and data collection times, will be documented in a standardised way to generate a comprehensive list of reported endpoints. In order to complete the identified outcomes in the literature search, focus groups on affected patients and structured interviews with board-certified dermatologists will be conducted to identify both patient- and practice-relevant endpoints. After the identification phase, the evaluation of the endpoints follows. In a two-stage Delphi procedure, experts including patient representatives will evaluate the endpoints in a standardised and transparent manner. A final face-to-face consensus meeting will be conducted after the last Delphi round in which a final list of core outcomes will be consented. The development of a standardised endpoint set for the treatment of AK will contribute to improving the comparability of therapeutic options. Our catalogue will enhance the synthesis of evidence for the future by reducing heterogeneity in outcomes between RCTs and hence contribute to improving the quality of research, evidence-based and patient-centred treatment. Core Outcome Measures for Effectiveness ( COMET ) database. Registered in December 2018.
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Skin lesion triage in organ transplant recipients using line-field confocal optical coherence tomography: a retrospective classification study. 使用线场共焦光学相干断层扫描对器官移植受者进行皮损分诊：一项回顾性分类研究。
Organ transplant recipients (OTRs) face an elevated risk of keratinocyte carcinomas (KC), leading to a lower threshold for biopsy. Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique capable of visualizing malignant skin changes, yet its role in the management of OTRs remains unexplored. The objective was to investigate the potential of LC-OCT for triage of skin lesions in OTRs. Clinically equivocal lesions in OTRs (n = 75) were scanned using LC-OCT before biopsy. Scans were assessed retrospectively for predefined LC-OCT criteria (i.e., image-markers) for KC and premalignant/in-situ lesions (Bowen's disease and actinic keratosis). The most high-yield criteria were identified and combined into a decision-tree. A 4-step decision-tree for lesion triage with five LC-OCT criteria was developed, with a sensitivity of 87.5 % for squamous cell carcinoma (n = 8), 94.4 % for basal cell carcinoma (n = 18), 83.3 % for Bowen's disease (n = 12), and 72.7 % for actinic keratosis (n = 22). This triage is based on severe dysplasia, broad strands and keratin pearls for SCC, lobules for BCC, and severe or mild-moderate dysplasia for premalignant lesions. This study designed an LC-OCT decision-tree for use in immunocompromised patients to assist in triage of equivocal skin lesions with potential for improving clinical-decision making.
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Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy. 接受咪喹莫特治疗的非黑色素瘤皮肤癌的光学相干断层扫描成像。
To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow-up. Complete data sets were available for 16 patients (8 women and 8 men aged 52-82 years), four in-compliant patients were excluded. OCT identified all lesions. Previously suggested OCT-criteria identified 5/8 BCCs. Crusting, ulceration and active treatment significantly reduced image quality. All BCCs cleared, but at follow-up residual structures were seen clinically in 4 cases. OCT and histology both ruled out residual BCC. For AKs significant thinning occurred after 1 week of treatment (P = 0.04). Imiquimod cleared 2/8 AKs, and significantly decreased the thickness of all lesions (P = 0.02). OCT could identify superficial BCC and AK before treatment. Monitoring during imiquimod treatment revealed impaired image quality most likely caused by inflammation, crusting and ulceration. On follow-up, OCT showed thinning of AKs indicating effect of treatment. All treated BCCs cleared, but where residual tissue was suspected clinically this could be ruled out by OCT.