INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS国际药用蘑菇杂志
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS(英文缩写 INT J MED MUSHROOMS),ISSN 1521-9437,eISSN 1940-4344,中文译名:国际药用蘑菇杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.706 | Q4 |
| 2022 | 1.200 | Q4 |
| 2023 | 1.400 | Q4 |
| 2024 | 1.400 | Q4 |
| 2025 | 1.600 | Q4 |
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 最新收录文献
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1. Traditional Knowledge and Study of Medicinal Properties of the Weeping Milk Cap Mushroom Lactarius volemus (Agaricomycetes) in México.
PMID:日期:2026-01-01Gathering and consumption of wild edible mushrooms are traditional practices in Mexico, influenced by the local culture of indigenous communities. In the Mestiza community of El Salto, municipality of Puente de Ixtla, Morelos, Mexico, traditional knowledge promotes the use and management of natural resources for meeting nutritional, economic, social, cultural, and environmental needs. Main mushroom species are gathered in the community for consumptions or marketing, involving women and men in the processes of collecting, consuming, cleaning, and selling. The traditional consumption of mushrooms supported healthy eating patterns, and Lactarius volemus was found to be a species of the most cultural importance (i.e., the highest frequency of mentioning in the interviews). Antioxidant and antibacterial properties of L. volemus extracts were analyzed and described. L. volemus showed significant DPPH free radical scavenging activity of 355.63 μg/mL, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) scavenging activity of 742.13 μg/mL, as well as bacteriostatic and bactericidal effects. Analyses of the minimal inhibitory concentration showed a high degree of susceptibility; the most potent minimal bactericidal concentration was 28.94 mg/mL recorded against Escherichia coli and Streptococcus agalactiae. Strategies for promoting mushroom consumption in indigenous and peasant communities, based on local cultural traditions, are discussed.
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2. Phenolic Profile and Biological Activities of Stropharia inuncta (Agaricomycetes) Extracts: Insights into Antioxidant, Enzyme Inhibition, and Cytotoxic Effects.
PMID:日期:2026-01-01The phenolic compound profile of ethanolic extract of Stropharia inuncta (Fr.) Quél., a natural macrofungus species, and the effects of this chemical structure on antioxidant, anticholinesterase and antiproliferative activities were evaluated. Antioxidant capacity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and Rel Assay Diagnostics kits; DPPH: 72.653 ± 1.857 mg Trolox equivalents (TE)/g, FRAP: 86.873 ± 1.125 mg TE/g, otal antioxidant status (TAS): 4.049 ± 0.057 mmol/L, total oxidant status (TOS): 9.642 ± 0.038 μmol/L, oxidative stress index (OSI): 0.238 ± 0.002, respectively. Within the scope of anticholinesterase activity, IC50 values of the extract on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were determined as 55.007 ± 1.411 μg/mL and 82.993 ± 1.501 μg/mL, respectively. Antiproliferative effect was evaluated on A549 human lung adenocarcinoma cell line after 24 h of incubation; significant decrease in cell viability was observed especially at concentrations of 100 and 200 μg/mL. Phenolic content was analyzed by LC-MS/MS method and the highest levels of gallic acid (3713.45 ± 12.26 mg/kg), quercetin (2911.40 ± 6.19 mg/kg), and 4-hydroxybenzoic acid (2167.69 ± 4.71 mg/kg) were detected. Also compounds such as vanillic acid, catechinhydrate and acetohydroxamic acid were found at significant levels. The findings show that S. inuncta is a rich natural source of phenolic compounds and this chemical structure contributes to versatile biological activities. The limited information in the literature on the biological activities and phenolic compound profile of this species positions the study as a contribution to the field.
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3. Integrative Network Pharmacology and Molecular Docking Elucidate the Multi-Target Mechanisms of the Artist's Conk Medicinal Mushroom Ganoderma applanatum (Agaricomycetes) Triterpenoids against Hepatocellular Carcinoma.
PMID:日期:2026-01-01Hepatocellular carcinoma (HCC) poses a significant global public health challenge, with conventional therapies often limited by severe adverse reactions. This study utilized network pharmacology and molecular docking to identify anti-HCC compounds from Ganoderma applanatum triterpenoids (GAT). Sixty compounds were screened using Swiss ADME, with potential targets predicted subsequently. Intersection analysis with HCC-associated targets identified 339 overlapping targets. Subsequent protein-protein interaction (PPI) network analysis identified nine core targets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses demonstrated that GAT inhibits HCC progression by modulating cancer-associated signaling pathways such as PI3K-Akt, MAPK, Ras, and Rap1 signaling. A compound-target network identified core compounds. Molecular docking demonstrated strong binding affinities between four compounds (applanaic acid C, methyl gibbosate A, bovistol, lucidone A) and three targets (AKT1, MAPK1, SRC). Toxicity predictions indicated low acute oral toxicity for applanaic acid C (LD50 > 300 mg/kg) and lucidone A (LD50 > 5000 mg/kg). Moreover, immunotoxicity risks were noted, which require key attention during subsequent drug development. This study systematically elucidates the multi-target and multi-pathway anti-HCC mechanisms of GAT providing a foundation for developing natural product-derived therapeutics. Further experimental validation of the efficacy and safety profiles is warranted for these potential lead compounds.
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4. Antioxidant, and Anticholinesterase Inhibitory Activities of Sarcosphaera crassa (Ascomycota) with Fatty Acids Profile.
PMID:日期:2026-01-01Sarcosphaera crassa is an edible but deadly mushroom that is poisonous in its raw form. In this study, fatty acids profiles, total phenolic, along with in vitro antioxidant and anticholinesterase activities of baked and raw forms of S. crassa were reported for the first time. Linoleic acid (53.6%), oleic acid (24.2%), and palmitic acid (11.5%) were present in the highest amount in the baked sample, while oleic acid (50.5%), palmitic acid (22.4%) and linoleic acid (16.6%) were found in the raw petroleum ether extract (in phenolic equivalents, PEs). PE extracts of raw and baked samples exhibited high phenolic content i.e. 18.8 ± 0.99 μg PEs/mg extract samples and 8.6 ± 0.22 μg PEs/mg extract samples. Similarly, water extract (WE) of baked [12.9 ± 0.03 μg quercetin equivalents (QEs)/mg extract, respectively] and raw (11.4 ± 0.12 μg QEs/mg extract respectively) samples had high flavonoid contents. Acetone extract (AE), methanol extract (ME), and WE of raw and baked S. crassa showed antioxidant activity in β-carotene-linoleic acid, DPPH·, ABTS+·, Fe2+-Ferrin, and CUPRAC assays. Acetone extract (IC50: 256.0 ± 2.0 μg/mL) and PE (IC50: 317.3 ± 1.5 μg/mL) of raw samples also showed moderate inhibitory activity against butyrylcholinesterase (BChE). This mushroom can be used to prevent rancidity in lipids due to peroxidation and may be helpful in healthy food products and as a food additive after cooking.
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5. LED Light Spectra Modulate Growth, Morphogenesis, and Bioactive Compound Production in Cordyceps militaris (Ascomycota).
PMID:日期:2026-01-01Light is a crucial environmental factor influencing fungal development and secondary metabolite biosynthesis. In this study, we investigated the effects of nine different LED light spectra on the growth, morphogenesis, and production of bioactive compounds in Cordyceps militaris strain DT22. Mycelial cultures and stromata were cultivated under controlled LED conditions, and their morphological characteristics, carotenoid, adenosine, and cordycepin contents were evaluated. Additionally, the expression levels of genes related to stromata development (CmHYD1), carotenoid biosynthesis (CmFHP), and cordycepin biosynthesis (CmCNS3) were analyzed by qRT-PCR. The results demonstrated that LED light treatments significantly influenced mycelial color, colony diameter, stromata formation, and biomass accumulation. Particularly, light formulas RW23 (2 Red:3 White) and wW (Warm White) promoted larger colony diameters and higher fresh and dry weights of stromata. Total carotenoid content peaked at the orange mycelial stage under RB (5 Red:1 Blue) and nW (Neutral White) treatments, but declined during primordia and mature stages. Cordycepin accumulation was highest under RBW (3 Red:2 Blue:1 White) treatment, whereas adenosine content showed no significant variation across light conditions. Gene expression analysis revealed that CmHYD1 and CmFHP were upregulated under most LED treatments, while CmCNS3 exhibited variable expression patterns. The mating-type gene MAT1.1.1 remained stable across treatments, whereas MAT1.1.2 showed a notable decrease under certain spectral conditions. Overall, our findings highlight the potential of tailored LED light combinations to optimize stromata production and bioactive metabolite synthesis in C. militaris, offering insights into environmental modulation strategies for industrial-scale cultivation.
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6. Bioactives of Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Targeting PPAR Signaling Pathway: An Experimental and In Silico Investigation.
PMID:日期:2026-01-01Hericium erinaceus is a widely consumed edible mushroom with significant ethnopharmacological value. Nevertheless, the pharmacological understanding of H. erinaceus presenting crucial bioactive compounds, their therapeutic targets, and its benefits across diseases in the form of bioactive-target-disease connectivity is yet to be explored. This study evaluates the antioxidant activity and cytoprotective effects of H. erinaceus extract on V79 fibroblast cells in vitro, to profile its bioactive compounds, and to conduct a network pharmacological analysis to identify key bioactives linked to therapeutic target proteins and diseases. A qualitative analysis identified the existence of tannins, alkaloids, steroids, terpenoids, polysaccharides, and phytosterols. Vibrational infrared spectroscopy confirmed the existence of alkanes, alkenes, alkynes, aromatics, aldehydes, esters, alcohols, aliphatics, and primary amines. Cytoprotective investigation demonstrated that the concentrations (10-25 μg/mL) of the extract preserve 95% cell viability and significant antioxidant properties. Gas chromatography-mass spectrometry analysis of the H. erinaceus extract yielded 49 components. The absorption, distribution, metabolism, excretion, and toxicity (ADMET)-filtered compounds were subjected to target prediction and pathway analysis, which revealed PPARG protein and its signaling pathways were the most significant targets. Further, disease association analysis identified PPARG's links to various diseases, which could benefit from using H. erinaceus. Molecular docking (-6.804 kcal/mol), binding free energy (-42.05 kcal/mol), and dynamic simulations confirmed a strong interaction between PPARG and 2-methyl hexadecanoic acid. These findings underscore the antioxidant and cytoprotective capabilities of H. erinaceus phytochemicals, as well as their potential therapeutic safety and efficacy for further investigation.
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7. Comparative Analysis of Extraction Techniques for Phenolics and Polysaccharides from Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes): Optimization and Yield Evaluation.
PMID:日期:2026-01-01Hericium erinaceus is widely recognized for its culinary and medicinal properties. This study evaluates various extraction techniques to optimize total phenolic and polysaccharide fractions in H. erinaceus. The objective was to determine the most suitable method for maximizing both yield and bioactivity of the extracts. We assessed the effectiveness of traditional soaking and ultrasonication for phenolic extraction, alongside hot water extraction, enzyme-assisted extraction, and cold and hot alkaline extraction methods for polysaccharide extraction. GC-MS metabolite profiling indicated that ultrasonic phenolic extraction combined with NaOH-based alkaline extraction was the most effective, yielding the highest polysaccharide content and demonstrating superior antioxidant activity. These findings highlight the efficacy of the extraction technique in isolating bioactive compounds rich in metabolites by reducing the extraction timeline, demonstrating its potential for diverse applications in the nutraceutical industry.
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8. In Vitro Antioxidant and Anti-Inflammatory Activity and Phenolic Compound Determination of King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) from Algeria.
PMID:日期:2026-01-01The current study investigates the biological efficacy and polyphenol and flavonoid content of aqueous and ethanolic 80% extracts of Pleurotus eryngii from the western region of Algeria. Total phenolic content (TPC) and total flavonoid content (TFC) were determined using colorimetric methods. The antioxidant activity was evaluated in vitro, whereas the anti-inflammatory activity was assessed via the protein denaturation method. The results indicated that the aqueous extract showed clear predominance across all evaluated indicators compared to ethanolic extract. It demonstrated a higher TPC and TFC [20.65 ± 0.27 mg of gallic acid equivalents (GAE)/g of extract and 5.69 ± 0.07 mg quercetin equivalents (QE)/g of extract, respectively], and enhanced antioxidant activity with an IC50 value of 714.57 ± 59.51 μg/mL for DPPH, along with greater reducing power (CA0.5 = 35.51 ± 1.86 μg/mL and EC50 = 687.89 ± 1.96 μg/mL) and elevated levels of total antioxidant capacity (TAC = 129.63 ± 1.14 μg AAE/g of extract). Moreover, the aqueous extract displayed significant anti-inflammatory activity, reaching an inhibition rate of 59.59% at a concentration of 1 mg/mL. LC-MS/MS analysis identified the phenolic acids as trans-cinnamic acid, gentisic acid and P-coumaric acid, with trans-cinnamic as main compound. These results illustrate the potent biological activity of the extracts of P. eryngii, indicating its potential for mushroom-based therapeutic applications.
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9. Identification of Pigments and Volatiles from Some Cultivated Culinary-Mushrooms in Malaysia.
PMID:日期:2026-01-01Food colorants are frequently used to improve product appearance which affect consumer perception. However, the colorants used in the food nowadays mostly made from synthetic sources. Therefore, there is a growing concern about the safety and health implications of these synthetic food colorants as consumption of synthetic colorants gives several negative side effects to people. Mushroom with pigment is seen as a new potential source of colors in food application. In this study, the chemical and physical characterization of extract from Pleurotus djamor, Auricularia auricula and Flammulina filiformis. Mushrooms were studied to introduce mushroom as a new source of natural colorants. Results showed that 22 volatile compounds were detected which are responsible in the aroma, flavoring agent and act as bioactive. HPLC analysis suggests that the extracts possibly contain eumelanin and pheomelanin since the findings from FTIR analysis revealed the presence of functional groups such as carboxylic acids, alcohols, and amines in these mushroom extracts. The morphology for each of the extracts were amorphous and varying in size. The extracts also showed high solubility in sodium hydroxide solution compared with other solvents. These findings highlight the potential usefulness of mushroom in providing an alternative in food colorants industry as one of the sources in natural colorants.
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10. Biochemical Characterization and Bioactive Properties of Boletus edulis (Agaricomycetes) from Serbia.
PMID:日期:2026-01-01The porcini mushroom, Boletus edulis, is an edible and medicinal ectomycorrhizal fungus belonging to the phylum Basidiomycota. In this study, we investigated the chemical composition and bioactive properties of its methanolic and acetonic extracts. Chemical characterization was performed using high performance liquid chromatography and gas chromatography coupled with mass spectroscopy. The most abundant components were potassium among elements (ICP-OES), chlorogenic acid among polyphenols (ion chromatography), malic acid among organic acids (UH-PLC-DAD-MS/MS), trehalose among carbohydrates (HPAEC-PAD), and palmitic acid among fatty acids (GC-MS). The antimicrobial activity, assessed by the microdilution method, showed minimum inhibitory concentration (MIC) values ranging from 1.25 to 40 mg/mL. Antioxidative activity was assessed spectrophotometrically using 1,1-diphenyl-2-picryl-hydrazil (DPPH) (IC50: 6.85 μg/mL and 614.23 μg/mL) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays (IC50: 8.33 μg/mL and 728.30 μg/mL) for methanolic and acetonic extracts, respectively, along with the reducing power assay (absorbance range 0.122-0.881). Additionally, total phenolic and flavonoid content was determined using Folin-Ciocalteu reagent and aluminum chloride method. The total content of phenolic compounds was 34.754 μg pyrocatechol equivalents (PE)/mg, and 35.403 μg PE/mg, and flavonoid content was 1.466 μg rutin equivalents (RE)/mg and 0.915 μg RE/mg for methanolic and acetonic extracts, respectively. The antidiabetic effect of the extracts was tested by the α-amylase (IC50 were 64.929 μg/mL and 71.505 μg/mL for methanolic and acetonic extract) and α-glucosidase assays (IC50 were 264.310 μg/mL and 725.151 μg/mL for methanolic and acetonic extract). The neuroprotective potential was investigated by assessing acetylcholinesterase inhibition (the results ranged from 5.40% to 43.54%). These results suggest that B. edulis has significant potential for biopharmaceutical applications.