Head & Neck Pathology头颈部病理学
Head & Neck Pathology(英文缩写 HEAD NECK PATHOL),ISSN 1936-055X,eISSN 1936-0568,中文译名:头颈部病理学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 2.100 | N/A |
| 2023 | 3.200 | Q2 |
| 2024 | 4.100 | Q1 |
| 2025 | 2.000 | Q3 |
Head & Neck Pathology 最新收录文献
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1. Claudin 18 Immunohistochemistry Expression in Salivary Gland Neoplasms: Limited Potential as a Therapeutic Biomarker.
PMID:日期:2026-09-24Claudin 18 (CLDN18) is a protein that functions to maintain the integrity of tight junctions in epithelial cells. Recent development of anti-Claudin 18.2 targeted therapies have yielded positive survival outcomes for patients with Claudin 18 expression in gastric carcinomas. This study aims to investigate whether expression of Claudin 18 is present in a variety of benign and malignant salivary gland neoplasms. Forty-eight cases of salivary gland neoplasms of various subtypes were included for this pilot study. Ancillary data including tumor location, grade, and stage of tumor as applicable was collected. Claudin 18 immunohistochemistry was performed on a representative tumor block of each case. No aberrant Claudin 18 expression was seen in the benign as well as malignant salivary gland neoplasms in this pilot study. CLDN18 expression was uniformly absent across the tumor types, locations, grades, and stages represented in this cohort. The absence of expression in all cases indicates that Claudin 18 has limited potential as a therapeutic marker in patients with salivary gland neoplasms. This study contributes to the extremely limited literature regarding Claudin 18 expression within salivary gland neoplasms.
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2. Immunohistochemical Predictors in Head and Neck Mucosal Melanoma.
PMID:日期:2026-09-22Mucosal melanoma is a rare disease with a poor prognosis, and its clinical signs and symptoms are nonspecific. This study aims to identify histopathological features and immunohistochemical markers of head and neck mucosal melanoma that characterize the tumor immunophenotype and are associated with patient survival. The study analysed head and neck mucosal melanoma diagnosed at Helsinki University hospital between January 1, 2011, and June 8, 2023. Samples were obtained from the Helsinki Biobank in Finland. New slides were prepared and stained for hematoxylin and eosin (H&E), CD3, CD4, CD8, Granzyme B (GrzB), CD68, CD117, p16INK4a, p53, SOX10 and PRAME. The study included 23 patients, 10 men and 13 women, aged 60-92 years (mean 75 years). The tumors were predominantly sinonasal. Ulceration was present in 15 cases, also 15 cases were amelanotic. Immunohistochemical staining SOX10 was positive in all tumors. PRAME was strongly positive in majority (20 cases, 87%). Strong p16 positivity was observed in 13 cases (57%), with a longer median survival compared to cases with weakened p16 expression (32.8 vs 13.8 months, p = 0.176). The median survival was also longer in the cases with high score of tumor infiltrating CD3-, CD8- and CD68-positive immune cells, though not statistically significant. Immunohistochemical markers routinely applied in cutaneous melanoma (SOX-10 and PRAME) are also expressed in head and neck mucosal melanoma. Tumour-infiltrating immune cells showed trend toward better survival, as has been previously found out in cutaneous melanoma. Strong p16 positivity may be an independent predictor of favorable prognosis in head and neck mucosal melanoma, irrespective of disease stage. Larger multicenter studies are warranted to validate these findings in this rare disease.
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3. Low-Grade Salivary Myoepithelial Carcinoma of the Upper Lip Harboring a Novel CARMN/miR143HG::PLAG1 Fusion.
PMID:日期:2026-09-22Myoepithelial carcinoma (MECA) represents a rare malignant neoplasm accounting for less than 2% of all salivary tumors, with recurrent PLAG1 rearrangements comprising its predominant underlying molecular aberration. A 48-year-old man presented with a 6-month history of a slow-growing, asymptomatic, pink-yellowish, submucosal nodule of the left upper lip measuring approximately 1.2 cm. An excisional biopsy was performed. Histologic examination revealed an infiltrative salivary neoplasm exhibiting a multilobulated growth pattern comprising numerous solid islands, nests, and anastomosing cords of lesional cells. A cribriform-like architecture was focally noted in association with pools of extracellular, amphiphilic, mucinous material. Neoplastic cells demonstrated predominantly epithelioid-to-plasmacytoid and in areas spindled cytomorphology, bland round-to-ovoid nuclei with granular chromatin, occasionally visible nucleoli, and abundant, eosinophilic, often vacuolated cytoplasm. Prominent nuclear pleomorphism and tumor necrosis were not present, while mitotic figures were infrequent (2 per 10 HPFs). Invasion of the adjacent adipose tissue was observed at the periphery of the lesion. The supporting stroma varied from fibrous-to-myxoid and featured mild acute and chronic inflammation. By immunohistochemistry, neoplastic cells were diffusely positive for CK7, SOX10, S100, and calponin, while p40 showed scattered/patchy immunoreactivity. They were negative for mammaglobin. The histomorphologic and immunophenotypic findings supported the diagnosis of low-grade MECA. RNA-based NGS revealed a CARMN/miR143HG::PLAG1 fusion, leading to a chimeric transcript between exons 1-2 of the long non-coding RNA host gene CARMN/miR143HG (chr5q32) and exons 3-5 of PLAG1 (chr8q12.1). We report on the clinical, histopathologic and immunophenotypic characteristics of a low-grade MECA of the minor salivary glands with a novel CARMN/miR143HG::PLAG1 fusion, expanding the molecular landscape of salivary myoepithelial neoplasia.
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4. An Accessible Approach to Molecular and Biomarker Testing for Risk Stratification in Oral Cavity Squamous Cell Carcinoma.
4. 一种用于口腔鳞状细胞癌风险分层的可及的分子和生物标志物检测方法PMID:日期:2026-09-18Oral cavity squamous cell carcinoma (OCSCC) is a common epithelial malignancy for which site-specific biomarkers with proven prognostic utility remain limited. In this study, we present one of the largest single-center, site-specific molecular analyses of OCSCC to date. Using two separate versions of multigene next-generation sequencing (NGS), we sought to identify a focused set of clinically actionable and widely accessible biomarkers that could support diagnosis, prognostication, and therapeutic decision-making. Our findings highlight the potential of a limited molecular panel to capture key prognostic information, supporting a more accessible and scalable approach to precision oncology in OCSCC. Seventy-three adult patients (ages 19-85 years) with site-specific OCSCC treated at City of Hope between 2019 and 2023 were included. Tissue specimens were collected at initial diagnosis or recurrence and analyzed using NGS panels for both DNA and RNA. Sequencing identified single nucleotide variants, copy number alterations, and gene fusions. Associations between genomic alterations and overall survival (OS) were assessed using Kaplan-Meier curves and log-rank tests with significance set at p < 0.05. TP53 and TERT-promoter oncogenic variants were the most frequent alterations, co-occurring in 64.4% of cases regardless of disease stage (primary vs. recurrence). Pathogenic variants in CDKN2A, HRAS, PIK3CA, BRCA1, and CASP8 were enriched among patients who developed recurrence. In this group, copy number amplification of CCND1, FGF3, FGF4, FGF19, RPS6KA4, RPS6KB2, and MYC, along with copy number loss of CDKN2A and CDKN2B, were observed. Lower PD-L1 expression, absence of TERT-promoter mutations (PMs), and focal amplification of 11q13 were associated with poor overall survival in univariate analysis (all p < 0.05). Multigene NGS profiling revealed recurrent genomic alterations and prognostic biomarkers in OCSCC. Based on these findings, we propose an initial biomarker panel comprising TP53 and PD-L1 (22C3 clone) immunostains, along with TP53 and TERT PM analysis. Collectively, these assays capture key prognostic biomarkers associated with adverse outcomes, including low PD-L1 expression (CPS < 20) and the absence of TERT PMs in relation to overall survival. In addition, copy-number assessment of 11q13, MYC (8q), and CDKN2A (9p) may warrant further investigation for future clinical application.
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5. Melanotic Oncocytic Metaplasia of the Nasopharynx: A Benign Mimic of Mucosal Melanoma.
PMID:日期:2026-09-11A 61-year-old man was found to have incidental multifocal, pigmented nasopharyngeal lesions during the evaluation of an unrelated thyroid nodule. The progressive appearance of multiple hyperpigmented macules on the torus tubarius raised concern for mucosal melanoma, an aggressive malignancy. Histopathologic examination ultimately established the diagnosis of melanotic oncocytic metaplasia, a benign lesion of the nasopharynx. Recognition of this entity is important because it may clinically and endoscopically mimic melanoma, yet it follows a benign course and requires only conservative management.
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6. Pattern-Anchored Diagnosis of Oral Epithelial Dysplasia: A Position Paper From COST Action INTERCEPTOR Working Group 2.
PMID:日期:2026-09-03Oral epithelial dysplasia (OED) is the principal histopathological marker for malignant risk stratification in oral potentially malignant disorders (OPMDs). Current World Health Organisation (WHO) three-tier and other binary grading systems are limited by modest inter-observer reproducibility and suboptimal prognostic discrimination, particularly for architecture-predominant lesions where cytological atypia is inconspicuous. The most clinically consequential failure of current practice is not mis-grading but non-recognition of dysplasia altogether, with direct implications for patient surveillance and management. This position paper, arising from Working Group 2 of COST Action CA21140 INTERCEPTOR, synthesises evidence from inter-observer reproducibility studies, feature-based prognostic models, under-recognition studies, outcome data and computational pathology analyses to propose and contextualise a pattern-anchored, grade-retaining diagnostic framework for OED. Five recognisable histological patterns are proposed: conventional/basaloid, keratinising/differentiated, verrucous, papillomatous, and HPV-associated, functioning as diagnostic anchors that capture the full morphological spectrum of OED, including architecture-predominant phenotypes that are disproportionately under-recognised in routine practice. Feature-based prognostic models demonstrate that architectural traits characterising these patterns (bulbous rete ridges, AUROC 0.74; cohesion loss, AUROC 0.73) predict malignant transformation more effectively than grade alone. Independent computational pathology analyses identify corresponding immune microenvironment and architectural signals as the strongest prognostic variables, providing convergent support. A two-step approach i.e. first identifying the dominant morphological pattern and then assigning grade within that pattern using existing WHO or binary criteria, offers a pragmatic, grade-retaining refinement compatible with current diagnostic frameworks and clinical pathways. The proposal is hypothesis-driven and requires prospective multicentre validation before wider adoption.
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7. Inflammatory Rhabdomyoblastic Tumor with Malignant Progression of the Neck: Unique Copy Number Profile Identified by Nanopore Sequencing.
PMID:日期:2026-08-29Inflammatory rhabdomyoblastic tumors (IRMT) are newly described entities characterized by a near-haploid karyotype. Most IRMTs exhibit indolent behavior; however, rare malignant transformation has been reported. We report a case of IRMT with malignant progression. A 67-year-old man presented with a painless mass in the left neck. Radiology revealed a 40-mm tumor in the left sternocleidomastoid muscle, with no evidence of distant metastasis. Core needle biopsy showed densely proliferating polygonal cells with pleomorphic nuclei, necrosis, and atypical mitoses. Based on histology, a preliminary diagnosis of pleomorphic rhabdomyosarcomas was made, although the clinical behavior seemed atypical. Nanopore DNA sequencing was subsequently performed and, within days, revealed characteristic molecular features, including relative gains of chromosomes 5, 7, and 22, a TP53 mutation, and DNA methylation profiling consistent with IRMT with malignant progression. The tumor was surgically resected, and pathological examination of the resected specimen confirmed a minor conventional IRMT component. Furthermore, infiltration of CD163-positive histiocytes was prominent, and fluorescence in situ hybridization analysis revealed two red signals (COL1A1 on chromosome 17) and four green signals (PDGFB on chromosome 22) in most tumor cells. Collectively, these histopathological, immunohistochemical, cytogenetic, and epigenetic findings established a final diagnosis of IRMT with malignant progression. Given the small tumor size, chemotherapy and radiotherapy were not administered. Nevertheless, the long-term behavior of IRMT with malignant progression remains unclear; thus, careful follow-up is warranted.
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8. Pathogenesis of Warthin's Tumors: A Critical Synthesis of the Evidence.
PMID:日期:2026-08-24Warthin tumor (WT) is the second most common benign parotid neoplasm, and its reported incidence has risen over recent decades, with a narrowing male predominance that parallels tobacco exposure trends. Whether WT is a true clonal neoplasm or a metaplastic process remains contested. We synthesize contemporary evidence on WT pathogenesis into a unified framework and articulate its diagnostic implications. Critical narrative synthesis. We searched PubMed/MEDLINE, Embase, and Web of Science from inception through May 16, 2026 for "Warthin tumor" and its synonyms combined with subtopic terms spanning pathogenesis, embryology, smoking, radiation, oncocytic and mitochondrial biology, cellular senescence, IgG4-related disease, viral association, clonality, malignant transformation, and synchronous neoplasia, with hand-searching of reference lists. No formal eligibility criteria, dual independent screening, or quantitative pooling were applied. Reporting follows the Scale for the Assessment of Narrative Review Articles (SANRA). Three converging lines of evidence account for WT pathogenesis: (1) an anatomic-embryologic substrate unique to the late-encapsulating parotid, in which salivary ductal epithelium is entrapped within intraparotid lymph nodes; (2) extrinsic-stressor-induced cellular injury and oncocytic metaplasia driven by tobacco, ionizing radiation, IgG4-mediated inflammation, or age-related mitochondrial decline; and (3) a permissive lymphoid microenvironment derived from pre-existing nodal parenchyma and actively remodeled by epithelium-derived chemokines. Clonality testing of conventional WT has been polyclonal, no recurrent oncogenic driver has been identified, and CRTC1-MAML2 has been reattributed to misclassified mucoepidermoid carcinoma. The available evidence favors conventional WT as a metaplastic-proliferative lesion of ductal epithelium entrapped within intraparotid lymph nodes and modulated by extrinsic stressors, rather than as a true clonal neoplasm. Whether a KRAS-mutant subset is genuinely neoplastic remains unresolved, since a single activating mutation does not by itself establish malignancy. The absence of a consistent oncogenic driver, the histologic heterogeneity of rare associated malignancies spanning multiple epithelial and lymphoid subtypes, and the synchronous occurrence of WT with oral and aerodigestive carcinomas favor a carcinogen-driven field effect over clonal progression.
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10. Discrepancies with Final Diagnosis in Head and Neck Intraoperative Frozen Section.
PMID:日期:2026-08-14Creating a frozen section slide and crafting an interpretation is a multistep process with multiple possible points of failure. Head and neck frozen section pathology presents particular technical and diagnostic challenges. The aim of our study was to identify discrepancies between head/neck intraoperative and final diagnoses, determine the site of process failure, and assess the potential causes. Concordance data from head and neck intraoperative and final diagnoses (2020-2023) were queried from our LIS-embedded quality assurance system. Discrepancies were categorized as major and minor, with major defined as those that would have altered the surgical procedure. We found 71 total discrepancies out of 1844 head and neck cases (3.9%). Major discrepancies accounted for 48/1844 (2.7%). Only major errors were considered for further study and were classified primarily into three categories: (1) inadequate gross sampling by the prosector, usually involving mucosal tissues of excised large specimens for evaluation of margins for dysplasia/carcinoma (14/48 cases; 29%), (2) insufficient sectioning into the block leaving undetected tissue unexamined (9/48 cases; 19%), and (3) interpretative errors (23/48 cases; 48%). The most common major interpretative errors involved the diagnosis of squamous dysplasia (9 cases), failure to identify minimally invasive squamous carcinoma (4 cases), failure to identify parathyroid and thyroid tissues (5 cases), and incorrect diagnoses of non-squamous neoplasms (5 cases). Two errors (4%) were ascribed to processing artifact issues in the frozen section. Half of diagnostic discrepancies occurred at steps prior to microscopic interpretation. Management of specimen grossing and tissue selection in large specimens, adequate block sectioning, and adherence to diagnostic criteria for difficult but common issues such as squamous dysplasia, minimally invasive carcinoma and thyroid/parathyroid morphology may help reduce intraoperative/final diagnosis discrepancies.