THROMBOSIS RESEARCH血栓形成研究
THROMBOSIS RESEARCH(英文缩写 THROMB RES),ISSN 0049-3848,eISSN 1879-2472,中文译名:血栓形成研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 10.409 | Q1 |
| 2022 | 7.500 | Q1 |
| 2023 | 3.700 | Q1 |
| 2024 | 3.400 | Q2 |
| 2025 | 3.400 | Q2 |
THROMBOSIS RESEARCH 最新收录文献
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1. Development and validation of a novel rivaroxaban calibrator: A routine anti-Xa assay solution with high agreement with LC-MS/MS.
PMID:日期:2026-09-24Therapeutic drug monitoring of rivaroxaban is essential for select patients, but anti-Xa assays can show discrepancies with the Liquid chromatography-tandem mass spectrometry (LC-MS/MS) reference method due to calibrator differences. This study aimed to develop and validate a novel rivaroxaban calibrator to achieve high interchangeability between the CX-9010 anti-Xa assay and LC-MS/MS. Samples were measured concurrently by the CX-9010 anti-Xa assay and LC-MS/MS. Agreement was assessed by Pearson correlation, Passing-Bablok (PB) regression, and Bland-Altman (BA) analysis stratified by concentration: absolute differences for samples ≤50 ng/mL (n = 108) and relative differences for samples >50 ng/mL (n = 92). Pearson correlation coefficient was 0.998. PB regression yielded a slope of 0.988 (95% CI: 0.978-0.998). For samples ≤50 ng/mL, absolute BA showed a mean bias of -0.73 ng/mL and 95% limits of agreement (LoA) of -8.74 to +7.28 ng/mL. For samples >50 ng/mL, relative BA showed a mean bias of -0.44% and LoA of -10.1% to +9.3%. Intra-vial CVs ranged from 0.85% to 2.52%, and inter-vial CVs from 0.95% to 2.21% across all six calibrator levels. Working calibrator stability over 34 h showed a maximum deviation of +4.91% relative to baseline, with all time-point deviations remaining within ±5%. The CX-9010 assay demonstrated strong agreement with LC-MS/MS in this single-center cohort. The calibrator quality met all predefined targets, supporting its use for routine clinical monitoring; multicenter validation is warranted before broader claims of interchangeability can be made.
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3. Efficacy and safety of tranexamic acid in non-gynecological abdominal and pelvic oncological surgery: a systematic review and meta-analysis.
PMID:日期:2026-09-09Abdominal and pelvic oncological surgeries are challenged with intraoperative blood loss, which leads to transfusion requirements and is linked to severe postoperative complications and poorer outcomes. Tranexamic acid (TXA), a synthetic antifibrinolytic agent, has been widely used to reduce bleeding and transfusion requirements in various surgical procedures. This systematic review focuses exclusively on the efficacy and safety of TXA administration in non-gynecological abdominal and pelvic oncologic surgeries. PubMed, Embase, and Web of Science databases were searched from inception to May 2025. Eligible studies evaluated the effect of TXA on bleeding outcomes in patients undergoing non-gynecological abdominal and pelvic oncologic surgery. Nine randomized controlled trials with a total of 2472 patients met the inclusion criteria. Data were synthesized using a random-effects model and reported as risk ratios (RR) for dichotomous outcomes and mean differences (MD) for continuous outcomes, with 95% confidence intervals (CI). TXA did not appear to significantly affect perioperative transfusion rate (RR =0.91, 95% CI: 0.66 to 1.26). Pooled analysis suggested that TXA was associated with a significant reduction in intraoperative blood loss (MD = -105.76, 95% CI: -200.51 to -11.01). For other outcomes-transfusion units (MD = -0.20, 95% CI: -0.72 to 0.33) or change in serum haemoglobin (MD = -1.13, 95% CI: -2.60 to 0.34), -no significant differences were detected. Mortality and risk of venous thromboembolism (VTE) did not differ significantly (RR = 2.30, 95% CI: 0.65 to 8.13) and (RR = 1.59, 95% CI: 0.93 to 2.72). Among patients undergoing non-gynecological abdominal and pelvic oncologic surgeries, TXA was not associated with a statistically significant reduction in perioperative transfusion rates or other clinically relevant outcomes, although a potential reduction in intraoperative blood loss was observed. Meanwhile, no statistically significant difference was observed in the risk of VTE and mortality.
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4. Study of centrifugal blood pump non-physiological shear stress induced platelet hemostatic dysfunction.
4. 离心式血泵非生理性剪切应力诱导血小板止血功能障碍的研究PMID:日期:2026-09-01To clarify how centrifugal blood pump-induced non-physiological shear stress affects platelet adhesion and aggregation, explaining the coexistence of thrombosis and bleeding during centrifugal pump support. Blood samples collected before and after centrifugal pump operation were used. Platelet adhesion, aggregation, and binding forces were evaluated using collagen and fibrinogen coated microfluidic chips and micropost arrays. Platelet receptor expression, vWF function, and pro-aggregatory factors were further investigated. After centrifugal pump operation, platelet adhesion to collagen decreased, especially under higher perfusion shear rates. The platelet and collagen binding force decreased from 33.04 nN to 8.73 nN, indicating impaired adhesive stability. This was associated with reduced platelet GPVI and GPIbα receptor expression, decreased vWF activity, and weakened platelet-vWF binding, suggesting inhibition of both GPVI mediated and vWF/GPIbα mediated adhesion. In contrast, platelet binding to fibrinogen increased, especially under higher perfusion shear rates. The platelet and fibrinogen binding force increased from 12.85 nN to 42.29 nN, indicating enhanced aggregation stability. This was accompanied by increased platelet GPIIb/IIIa receptor activation and elevated pro-aggregatory factors. However, prolonged centrifugal pump operation reduced platelet responsiveness to secondary stimulation and decreased GPIIb/GPIIIa subunit availability, suggesting that sustained shear exposure limits further platelet activation and aggregation. Centrifugal blood pump induced non-physiological shear stress impairs collagen mediated initial adhesion while enhancing fibrinogen mediated aggregation. Sustained shear exposure weakens platelet secondary responsiveness and limits further enhancement of aggregation hemostasis. These findings reveal a potential mechanism for the coexistence of thrombosis and bleeding and provide a microfluidic method for hemocompatibility assessment.
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5. Residual VTE risk after early ICU thromboprophylaxis: risk stratification in MIMIC-IV and an imaging-follow-up cohort.
PMID:日期:2026-09-01Pharmacological thromboprophylaxis reduces but does not eliminate venous thromboembolism (VTE) risk in critically ill patients. We assessed whether early routine ICU data stratify clinically recognized VTE risk among patients receiving early pharmacological thromboprophylaxis. We performed a retrospective 24-hour landmark prediction-model study using MIMIC-IV v3.1. Adult ICU stays with pharmacological thromboprophylaxis within 24 h were included. The primary endpoint was clinically recognized VTE before hospital exit, defined by the VTE diagnosis phenotype and temporally anchored to the first positive radiology evidence; death was not included in the endpoint. Six models were compared using fold-contained preprocessing, five-fold outer cross-validation and three-fold inner tuning. Conventional multivariable logistic regression, cause-specific Cox regression and Fine-Gray competing-risk regression were used to identify independent determinants; VTE-free hospital exit was treated as the competing event in time-to-event analyses. A prospective observational hospital imaging-follow-up cohort provided descriptive imaging results, exploratory local classification and a landmark-aligned independent validation subset for the frozen MIMIC model. The MIMIC-IV cohort included 5702 ICU stays and 174 VTE events (3.1%). Elastic net achieved AUROC 0.709, average precision 0.083 and Brier score 0.029. The highest-risk 20% captured 48.3% of events (event rate 7.36%; sensitivity 48.3%; specificity 80.9%; positive predictive value 7.4%). Among patients without preceding VTE, 717 deaths and 4811 discharges were treated as competing hospital exits. Estimated cumulative VTE incidence was 1.58% at day 7 and 2.24% at day 14. Fine-Gray regression identified invasive ventilation (adjusted subdistribution hazard ratio [sHR] 1.82, 95% CI 1.28-2.60), vasopressor/inotrope use (adjusted sHR 2.02, 95% CI 1.40-2.93) and renal replacement therapy (adjusted sHR 1.92, 95% CI 1.03-3.60) as independent determinants. In the hospital cohort, 25 of 138 patients had imaging-confirmed PE (18.1%). The landmark-aligned validation subset included 96 patients and 36 post-landmark imaging-confirmed VTE events; the frozen common-variable MIMIC model yielded AUROC 0.581 and average precision 0.461. Early routine ICU data stratified clinically recognized VTE risk after early prophylaxis exposure. At the 4.33% threshold, the highest-risk 20% contained nearly half of recognized VTE events. This fixed threshold provides a candidate entry rule for prospective evaluation of structured reassessment and imaging-priority strategies.
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8. Direct oral anticoagulants versus low-molecular-weight heparin in Asian patients with cancer-associated venous thromboembolism: A systematic review and meta-analysis.
PMID:日期:2026-09-01Direct oral anticoagulants (DOACs) are increasingly used as an alternative to low-molecular-weight heparin (LMWH) for cancer-associated venous thromboembolism (VTE), but evidence in Asian patients remains limited. We searched PubMed, Embase, Web of Science, and the Cochrane Library for randomized or comparative observational studies comparing DOACs with LMWH for cancer-associated VTE in Asian patients. Primary outcomes were recurrent VTE and major bleeding. Weighted hazard ratios (wHR) were pooled as the primary analysis; subdistribution hazard ratios (sHRs) from competing-risk models were pooled as a sensitivity analysis. Seven observational studies comprising 13,387 patients were included; one early-terminated randomized trial was included in sensitivity analyses. In the primary analysis, DOACs were associated with lower recurrent VTE than LMWH (wHR 0.71, 95% CI 0.54-0.93), with similar major bleeding (wHR 0.85, 95% CI 0.70-1.04). All-cause mortality was lower with DOAC (wHR 0.66, 95% CI 0.60-0.71). After accounting for competing mortality, associations were attenuated for recurrent VTE (sHR 0.95, 95% CI 0.67-1.33) and shifted upward for major bleeding (sHR 1.09, 95% CI 0.95-1.26). In subgroup analyses, major bleeding was higher with a DOAC switching strategy (sHR 1.19, 95% CI 1.01-1.41); and in an exploratory competing-risk analysis, gastrointestinal bleeding was higher among patients with gastrointestinal cancer (p for subgroup difference = 0.041). In Asian patients with cancer-associated VTE, DOACs showed favorable associations in weighted analyses, but these were attenuated after accounting for competing mortality. Given the observational nature of the available evidence and marked mortality imbalance between treatment groups, these findings should be considered hypothesis-generating.
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9. ReSTORE-PE (Rehabilitation to Support Total Recovery after Pulmonary Embolism): Development of a co-designed rehabilitation programme for post-pulmonary embolism syndrome.
PMID:日期:2026-09-01Approximately 50% of pulmonary embolism (PE) survivors experience persistent physical and psychological symptoms consistent with post-pulmonary embolism syndrome (PPES), negatively affecting quality of life, functional recovery, and engagement in healthy lifestyle behaviours. Although rehabilitation is recommended following PE, limited evidence exists to guide intervention design for this population. To develop a rehabilitation programme prototype to support physical and psychological recovery in individuals living with PPES using a theory-informed co-design process. Intervention development followed the United Kingdom Medical Research Council framework and incorporated the Behaviour Change Wheel, Theoretical Domains Framework (TDF), Behaviour Change Techniques Ontology, Behaviour Change Intervention Ontology, and Theory and Techniques Tool. A three-stage co-design process was undertaken: (1) behavioural analysis, (2) selection of intervention components, and (3) refinement of the intervention prototype. Development was informed by two reviews, semi-structured interviews with people living with PPES (n = 31), and three co-design workshops involving people living with PPES (n = 5), clinicians, and academics (n = 8). Behavioural analysis identified all 14 TDF domains, with key determinants including knowledge, beliefs about capabilities, emotion, environmental context, and social influences. These were mapped to eight intervention functions and more than 50 behaviour change techniques. Strongest evidence supported goal setting, self-monitoring, feedback, action planning, and graded tasks. A clinician-led, community-based rehabilitation programme was developed, integrating supervised exercise, education, psychological support, and self-management training. ReSTORE-PE is a theory-informed, co-designed rehabilitation programme for people living with PPES that is ready for feasibility and acceptability testing. The transparent development process supports future implementation, evaluation, and replication.
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10. External validation and model updating of the Cleveland Clinic Model for risk assessment of venous thromboembolism in medical inpatients.
PMID:日期:2026-09-01Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in medical inpatients. The Cleveland Clinic Model (CCM), a novel risk assessment model (RAM) to guide thromboprophylaxis, has never been independently validated. To validate and update the CCM, and compare its prognostic accuracy with the Padua Prediction Score (PPS) and the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) score. We used data from a prospective cohort of medical inpatients admitted >24 h to general internal medicine wards at 3 Swiss university hospitals (06/2020-01/2022). The outcome was objectively confirmed symptomatic VTE within 90 days. Patients were stratified into higher and low VTE-risk groups by RAM. We compared test characteristics across 3 versions of the CCM (original CCM and 2 updated versions, 1 with a derived cut-off, and 1 modified derived cut-off version with 45-day follow-up and without missing variables), the PPS, and the IMPROVE score and drew calibration plots for the original and modified derived cut-off CCM. Of 1352 medical inpatients, 28 (2.1%) experienced VTE within 90 days. The 90-day VTE cumulative incidence was 2.48% in higher-risk vs. 1.91% in low-risk patients (P = 0.52) according to the original CCM. Discrimination was poor across all RAMs (areas under the receiver operating characteristics curve ≤60%). In calibration plots, the original and modified derived cut-off CCMs underestimated the VTE risk. In this non-U.S., non-ICU cohort, all RAMs showed comparable but limited accuracy for predicting VTE up to 90 days. Updating the original CCM did not improve predictive performance.