LASERS IN MEDICAL SCIENCE激光医学科学
LASERS IN MEDICAL SCIENCE(英文缩写 LASER MED SCI),ISSN 0268-8921,eISSN 1435-604X,中文译名:激光医学科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.555 | Q2 |
| 2022 | 2.100 | Q2 |
| 2023 | 2.100 | Q2 |
| 2024 | 2.400 | Q1 |
| 2025 | 2.700 | Q1 |
LASERS IN MEDICAL SCIENCE 最新收录文献
-
1. Effectiveness of a novel low-level laser therapy protocol in managing breast cancer-related lymphedema.
PMID:日期:2026-09-24In this study, we investigate the effects of low-level laser therapy (LLLT) at different wavelengths on lymphedema to further determine the appropriate protocol and effectiveness of LLLT in patients with breast cancer-related lymphedema (BCRL). A randomized controlled trial was conducted involving 46 patients with BCRL. Participants were assigned to receive 904 nm LLLT, 650 nm LLLT, or sham treatment. ICG lymphography was used to assess dermal backflow as a marker of lymphatic dysfunction. Ultrasonography was used to assess subcutaneous thickness and tissue mechanical properties; shear wave velocity (SWV), with higher values indicating greater tissue stiffness, was measured using shear wave elastography. Extracellular fluid volume and local tissue water content were evaluated using multifrequency bioelectrical impedance analysis (MFBIA) and tissue dielectric constant (TDC), respectively. No significant between-group differences were observed in ICG lymphography, MFBIA, or TDC outcomes. For ultrasonographic outcomes, the overall between-group difference in the change in upper-lateral SWV ratio was significant (p = 0.029), and Bonferroni-adjusted post-hoc analysis showed a greater reduction in Group A (904 nm) than in Group B (650 nm) (adjusted p = 0.026). Within Group A, SWV ratios decreased significantly at the lower-lateral site and at the LLLT treatment site. These site-specific findings were not accompanied by measurable changes in lymphatic transport or fluid-related outcomes. Adding 904 nm-650 nm LLLT to conventional decongestive therapy did not produce significant additional effects on extracellular fluid-related or lymphatic functional outcomes. Site-specific reductions in SWV observed with 904 nm LLLT suggest a potential wavelength-dependent effect on local tissue mechanical properties; however, these findings are limited and should be considered exploratory. Larger adequately powered studies with prespecified primary outcomes and longer follow-up are required.
-
2. Combined photobiomodulation and exosome therapy for muscle and tendon regeneration: an experimental rabbit study.
PMID:日期:2026-09-23Achilles tendon injuries are common, especially among athletes, and their treatment remains challenging. Reduced muscle strength and immobility can exacerbate tendon stiffness, leading to disability. This study investigated the effects of adipose tissue-derived mesenchymal stem cell exosomes and low-level laser therapy (LLLT) on muscle and Achilles tendon elasticity in a rabbit model. Twelve New Zealand white rabbits underwent ultrasound imaging of Achilles tendons and gastrocnemius muscles with a 40 MHz probe during flexion and dorsiflexion. Foot stress during movement was measured. To create a partial tendon injury, a 5 mm longitudinal incision, 3 mm deep, was made in the Achilles tendon. Male rabbits were randomly divided into four groups: control, LLLT (830 nm, 15 mW, 3 J/cm²), exosome injection (200 µg/mL), and combined LLLT with exosomes. Treatments were applied on days 1, 8, and 15. Ultrasound evaluations were performed before injury, immediately after, and on days 8 and 21. Tendon and muscle samples were analyzed histologically with hematoxylin-eosin staining. On day 21, the force applied to induce flexion and dorsiflexion of the Achilles tendon and gastrocnemius muscle significantly increased in the combined treatment group compared to the others (P < 0.05). The thickness strain of both muscle and tendon improved significantly with combination therapy (P < 0.05). Histology showed compact, parallel collagen fibers and a well-organized extracellular matrix in tendons treated with LLLT and exosomes. No inflammation was observed, and muscle atrophy was reduced. Combining low-level laser therapy with exosomes derived from ADSCs enhanced the histological, ultrasound-derived, and mechanical aspects related to Achilles tendon repair. This included improvements in tendon and gastrocnemius strain, as well as flexion and dorsiflexion force.
-
3. Clinical effectiveness of Er, Cr: YSGG laser compared with conventional rotary instrumentation for caries removal in primary teeth: a randomized split-mouth clinical trial.
PMID:日期:2026-09-22To compare the clinical efficacy of erbium, chromium-doped yttrium scandium gallium garnet (Er, Cr: YSGG) laser versus conventional air-rotor handpiece for caries removal in primary teeth and their effects on children's anxiety and pain levels, to provide evidence for optimizing pediatric dental treatment. A total of 90 children (aged 6-10 years) with primary tooth caries were enrolled. Using a split-mouth design, two carious teeth from each child were randomly assigned to air-rotor handpiece treatment (Group A, 90 teeth) or Er, Cr: YSGG laser treatment (Group B, 90 teeth). Clinical efficacy, restoration quality (United States Public Health Service [USPHS] criteria), masticatory function (bite force, chewing efficiency), adverse events, and children's anxiety (Venham Anxiety and Behavior Rating Scale, Faces Image Scale [FIS], pulse rate) and pain levels (Wong-Baker FACES Pain Rating Scale) were compared. Group B exhibited significantly lower Venham scores, pulse rates, FIS scores, and Wong-Baker pain scores post-treatment (P < 0.01). Additionally, no significant difference was observed in overall clinical efficacy (Group A 83.33% vs. Group B 91.11%, P = 0.18). However, Group B showed significantly better USPHS scores in sensitivity, secondary caries, and marginal staining (P < 0.01), greater improvement in masticatory function (P < 0.05) and a lower incidence of adverse events (P = 0.01). Er, Cr: YSGG laser may represent an effective minimally invasive alternative for caries removal in primary teeth, particularly due to its potential benefits in reducing treatment-related pain and anxiety. Further long-term studies are required to confirm its effects on restoration longevity and clinical outcomes.
-
4. {"_":"Effect of CO laser irradiation on shear bond strength and enamel surface roughness after ceramic brackets removal: in vitro study.","sub":["2"]}
PMID:日期:2026-09-22This study aimed to evaluate the shear bond strength and surface roughness of the enamel after removal of ceramic brackets with CO laser. Thirty extracted premolars were randomly assigned to three groups (n = 10): Untreated enamel (GI), Conventional debonding (GII), and CO laser debonding (GIII). Polycrystalline ceramic brackets were adhered on the buccal surface of GII and GIII groups, using 35% phosphoric acid and Transbond Plus Color Change resin (3 M Unitek; Monrovia, California, USA); shear bond strength was evaluated with a universal testing machine (EZ Graph; Shimadzu, Kyoto, Japan). Prior to debonding, brackets in the GIII group were irradiated with a CO laser (Yoshida Dental MFG; Tokyo, Japan) at a wavelength of 10.6 μm, power output of 6 W, for 5 s, at 5 mm. Each specimen was evaluated for adhesive remnant index score, and enamel surfaces were polished to assess roughness (with and without the CO laser) under atomic force microscopy. Ra, Rq, and Ry roughness parameters were analyzed. Statistical analysis was carried out using Student's t-test to evaluate shear bond strength, the Mann-Whitney U to assess the adhesive remnant index, and the Kruskal-Wallis and Dunn's post hoc to examine enamel roughness. GIII group showed statistically significant differences, with a reduction in shear bond strength (p < 0.001) and enamel roughness (p < 0.0083) compared to GII. These findings indicate that CO laser irradiation can be considered as an alternative in debonding ceramic brackets in orthodontic treatments.
-
5. Effectiveness of low-level laser therapy in the rehabilitation of knee meniscus injuries: a randomized, double-blind, placebo-controlled trial.
PMID:日期:2026-09-19To evaluate the effectiveness of low-level laser therapy (LLLT) as an adjunct to rehabilitation in reducing pain and improving knee function in adults with MRI-confirmed meniscus injuries. In this randomized, double-blind, placebo-controlled trial, 40 adults with unilateral meniscus injuries were assigned to either an LLLT group or a placebo group. All participants received a standardized rehabilitation program over six weeks. The primary outcome was pain intensity measured using a visual analogue scale (VAS). Secondary outcomes included knee function (Lysholm score), range of motion (ROM), and physical performance tests. Both groups showed significant improvements; however, the LLLT group demonstrated greater reductions in pain and improvements in function, mobility, and ROM compared with the control group (p < 0.01 for all outcomes). The magnitude of improvement exceeded clinically meaningful thresholds, particularly for pain reduction and functional gains. Adjunctive LLLT was associated with greater improvements in pain and functional outcomes compared with rehabilitation alone. LLLT appears to be a safe and potentially effective complementary modality in the conservative management of meniscal injuries.
-
6. Single-session extraoral photobiomodulation reduces early postoperative pain but not edema or trismus after impacted mandibular third molar extraction: a randomized controlled trial.
6. 单次口外光生物调节可减轻阻生下颌第三磨牙拔除术后早期疼痛，但不减轻水肿或张口受限：一项随机对照试验PMID:日期:2026-09-16Postoperative pain, edema, and trismus are frequent complications following impacted mandibular third molar surgery. While photobiomodulation (PBM) is a proposed adjunctive therapy, clinical evidence remains controversial. This study evaluated the effects of single-session extraoral dual-wavelength PBM (650 + 904 nm) applied immediately after extraction on postoperative pain, edema, trismus, and quality of life (QoL). This prospective RCT enrolled 70 patients (mean age: 22.04 ± 2.61 years) with asymptomatic mesioangular impacted mandibular third molars (Pell-Gregory Class IB). Participants were randomized to a PBM (n = 35) or control (n = 35) group. Following standardized surgical extraction by a single surgeon, the PBM group received a 10-minute extraoral application (650 + 904 nm, GaAlAs laser). The primary outcome was postoperative pain, assessed by VAS on postoperative days 2 and 7. Secondary outcomes included QoL (VAS, days 2 and 7), edema (sum of three facial distances), and trismus (maximum interincisal distance), the latter two evaluated at baseline and on postoperative days 2 and 7. On postoperative day 2, pain VAS scores were significantly lower in the PBM group (20.34 ± 24.38 vs. 41.43 ± 25.15; p < 0.001) and QoL scores significantly higher (69.83 ± 25.87 vs. 50.51 ± 23.24; p = 0.002) compared to controls. By day 7, a statistically significant but clinically negligible between-group difference persisted in pain (Mann-Whitney U = 776.5, p = 0.040; mean difference 2.6 mm), while QoL no longer differed significantly between groups (p = 0.154). No significant between-group differences were observed for edema or trismus at any time point (p > 0.05). Single-session extraoral dual-wavelength PBM significantly reduces early postoperative pain and improves QoL on the second postoperative day following impacted third molar extraction, with no significant effect on edema or trismus. The clinically meaningful pain and QoL benefits resolved by day 7, and sham-controlled multi-session trials are warranted.
-
7. Efficacy of photobiomodulation in perineal trauma after vaginal delivery: a protocol for a randomized, blinded clinical trial.
PMID:日期:2026-09-15To evaluate the efficacy of photobiomodulation (PBM) in reducing perineal pain and obstetric vulvar edema, as well os its effects on maternal functioning during the immediate postpartum period. This randomized, controlled, double-blind clinical trial protocol will include women aged over 15 years, within 12 h after vaginal delivery, presenting with first- or second-degree perineal trauma and/or vulvar edema and pain ≥ 3 on the Numeric Rating Scale. Participants will be randomized in blocks of four to receive PBM or a sham intervention alongside usual postpartum care. A single PBM session will be performed using 808-nm infrared laser light at an output power of 100 mW. Assessments will be performed at baseline, immediately after the intervention, 12 h, 40 days, and three months postpartum. Outcomes will include pain, pressure pain threshold, vulvar edema area, maternal functioning, treatment satisfaction, urinary incontinence, and sexual function. Statistical analysis will follow the intention-to-treat principle using linear mixed-effects models, with group, time, and group × time interaction as fixed effects and participant as a random effect. Post-hoc comparisons will use Bonferroni correction, with a significance level of 5%. PBM is expected to reduce perineal pain and vulvar edema and improve maternal functioning. The randomized design, sham control, blinded outcome assessment, and longitudinal analysis are expected to provide evidence regarding the efficacy and safety of PBM as a non-pharmacological strategy for postpartum care. Brazilian Clinical Trials Registry (REBEC), RBR9sgdsm2, approved on July 7, 2026.
-
8. Photoacoustic imaging-based assessment of vascular changes in scars: a retrospective analysis of factors influencing PDL treatment efficacy.
PMID:日期:2026-09-15Pulsed dye laser (PDL) is widely used for hypervascular scars, but real-time evaluation of vascular responses remains limited. Photoacoustic imaging (PAI) enables noninvasive, high-resolution assessment of skin microvasculature. To assess whether PAI can visualize post-PDL vascular changes in real time and identify factors influencing efficacy. This single-center retrospective study analyzed 32 scars treated with 595-nm PDL. Patients were grouped by pulse duration/fluence combination (0.45-6.0 J/cm², 1.5-8.0 J/cm², or 3.0-10.0 J/cm²) or by endpoint (purpuric or nonpurpuric response). PAI, Antera 3D, and Vancouver Scar Scale (VSS) assessments were performed at baseline, immediately after treatment, and 1 month later. PAI enabled real-time, layer-specific visualization of vascular change, a capability that is less readily achievable with the VSS or Antera 3D. No statistically detectable association was identified between the parameter combinations and PDL outcomes. By contrast, the treatment endpoint was significantly associated with vascular outcomes: compared with purpuric treatment, nonpurpuric treatment showed lower adjusted full-dermis vessel density (30.25% vs. 49.29%; difference, - 19.04%; 95% CI, - 28.12 to - 9.97; Holm-adjusted P < 0.001) and smaller vessel diameter (278.74 μm vs. 428.36 μm; ratio, 0.651; 95% CI, 0.500-0.846; Holm-adjusted P = 0.002). Layer-specific outcomes also showed a similar direction of effect. In the exploratory repeated-treatment subset, NPUR was associated with progressive vascular improvement. PAI helps characterize vascular features and may provide additional information to support overall treatment parameter selection. Treatment endpoint was significant correlated to vascular efficacy. PAI suggests that vascular closure without purpura maybe potentially favorable.
-
9. Effectiveness of high-power laser use in the removal of esthetic restorations: a systematic review.
PMID:日期:2026-09-15This systematic review aimed to evaluate the effectiveness of high-power lasers in the removal of esthetic restorations compared with conventional methods. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and registered in PROSPERO (registration number: CRD420251055736). A comprehensive electronic search was performed in MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Library. Study selection, data extraction, and methodological quality assessment were independently performed by four reviewers using QUIN tool for in vitro studies. A total of 2.384 records were identified, of which 19 in vitro studies conducted on extracted human permanent teeth met the eligibility criteria and were included in the qualitative synthesis. The included studies evaluated different high-power laser systems, predominantly Er: YAG and Er, Cr: YSGG lasers, as well as CO₂ lasers. Five studies were classified as high quality, whereas the remaining fourteen studies were classified as moderate quality. Available laboratory evidence suggests that laser-assisted techniques may represent a potential alternative approach for removing esthetic restorations, with advantages including conservative tissue removal, reduced damage to underlying tooth structures, and intrapulpal temperature increases within acceptable limits. The Er: YAG laser was the most frequently investigated system, with power settings ranging from 1.5 to 5.9 W, showing particularly favorable laboratorial performance in the removal of lithium disilicate restorations, especially in thinner substrates. Within the limitations of the available evidence, high-power lasers appear to be a promising and minimally invasive alternative to conventional methods for the removal of esthetic restorations. However, the predominance of in vitro studies highlights the need for well-designed clinical trials to confirm these findings and support their clinical application.
-
10. Excimer laser angioplasty for acute coronary occlusion: a stratified meta-analysis of efficacy against aspiration thrombectomy and conventional PCI.
PMID:日期:2026-09-15Primary percutaneous coronary intervention (PCI) achieves epicardial reperfusion in most STEMI patients, yet microvascular obstruction persists in up to 60% of patients. Excimer laser coronary angioplasty (ELCA) vaporizes thrombus in situ and may reduce distal embolization, but the evidence base has not been systematically synthesized. This systematic review and meta-analysis (PROSPERO CRD420261422463) included comparative studies of adjunctive ELCA versus aspiration thrombectomy (Stratum A) or PCI alone (Stratum B) in acute coronary occlusion. Primary outcomes were final TIMI-3 flow and myocardial blush grade (MBG) 3; secondary outcomes were short-term mortality, MACCE, and slow-flow/no-reflow. A random-effects model with Hartung-Knapp-Sidik-Jonkman confidence intervals was applied to all outcomes. Certainty was assessed with GRADE. Ten studies (1 RCT, 9 observational) were included, from a total enrolled population exceeding 3,500. In Stratum A, no outcome reached significance: MBG-3 (OR 3.57, 95% CI 0.07-185.10), mortality (OR 0.31, 0.02-4.04), MACCE (OR 0.22, 0.04-1.26), TIMI-3 flow (OR 1.58, 0.67-3.75) and slow-flow/no-reflow (OR 0.78, 0.22-2.78). In Stratum B, using each study's propensity-matched data, no outcome differed significantly (TIMI-3 OR 0.88, 0.38-2.03; MBG-3 OR 1.06, 0.13-8.43; slow-flow/no-reflow OR 0.93, 0.29-3.02; mortality OR 0.44, 0.05-3.80). Composite endpoints were not pooled across incompatible follow-up horizons, and all outcomes were of very low certainty. Adjunctive ELCA-containing strategies during primary PCI were not associated with improved angiographic or short-term clinical outcomes against either comparator. Multicenter randomized trials are required before recommending clinical adoption.