Turkish Journal Of Medical Sciences土耳其医学科学杂志
Turkish Journal Of Medical Sciences(英文缩写 TURK J MED SCI),ISSN 1300-0144,eISSN 1303-6165,中文译名:土耳其医学科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.925 | Q3 |
| 2022 | 2.300 | Q3 |
| 2023 | 1.200 | Q2 |
| 2024 | 1.000 | Q3 |
| 2025 | 1.400 | Q2 |
Turkish Journal Of Medical Sciences 最新收录文献
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1. Histomorphological changes in human septal cartilage stored in different preservation solutions.
PMID:日期:2026-07-21To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery. A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically on days 0, 15, and 30. The evaluated parameters included chondrocyte count/cellularity, the percentage of empty lacunae, chondrocyte morphology, erosion score, inflammation, and necrosis. Evaluations were blinded. Progressive time-dependent histomorphological deterioration was observed in all preservation groups. From baseline to day 30, the ciprofloxacin group showed a greater reduction in chondrocyte count and a greater increase in the percentage of empty lacunae than the povidone-iodine group (adjusted p = 0.043 and p = 0.029, respectively). Although ethanol showed relatively favorable morphological findings at day 15, substantial deterioration was observed by day 30. Chondrocyte morphology and erosion scores also deteriorated over time. Inflammation and necrosis remained minimal across all groups. All tested preservation solutions were associated with progressive, time-dependent histomorphological deterioration of septal cartilage. No single preservation solution demonstrated consistently superior preservation across all evaluated histopathological parameters. Further biomechanical and biochemical studies are required to establish optimal cartilage preservation protocols.
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2. Association of PRECISE-HBR score with clinical outcomes and length of hospital stay after transcatheter aortic valve implantation.
PMID:日期:2026-07-01The PRECISE-HBR score was developed to estimate bleeding risk after percutaneous coronary intervention, but its clinical utility in patients undergoing transcatheter aortic valve implantation (TAVI) remains uncertain. We evaluated its association with major bleeding and hospitalization burden after TAVI. This ambispective, single-center observational study included 184 consecutive patients undergoing TAVI. The patients were categorized by PRECISE-HBR score (≤22, 23-26, and ≥27) for descriptive comparisons. Receiver operating characteristic analyses were used to assess the discriminative performance of PRECISE-HBR and the Society of Thoracic Surgeons score for major bleeding, prolonged hospitalization, and in-hospital mortality. Binary logistic regression was utilized to evaluate associations between each one-point increase in PRECISE-HBR and clinical outcomes, while correlation analyses were used to assess relationships with length of stay. Higher PRECISE-HBR scores were associated with older age, female sex, hypertension, and chronic kidney disease. Major bleeding increased across score categories (7.7%, 19.4%, and 34.6%; p = 0.010) and total hospital stay was longer in the highest category (p = 0.033). PRECISE-HBR score showed weak positive correlations with intensive care unit stay (r = 0.270, p < 0.001), ward stay (r = 0.148, p = 0.044), and total hospitalization duration (r = 0.244, p = 0.001). Discrimination was moderate for major bleeding (AUC 0.748, 95% CI 0.662-0.824) and modest for prolonged hospitalization (AUC 0.615, 95% CI 0.532-0.694). Each one-point increase in PRECISE-HBR score was associated with major bleeding (OR 1.15, 95% CI 1.09-1.22; p < 0.001) and prolonged hospitalization (OR 1.06, 95% CI 1.02-1.11; p = 0.007), but not in-hospital mortality. Higher PRECISE-HBR scores were associated with major bleeding and longer hospitalization after TAVI. The score may aid bleeding-risk assessment and estimation of hospitalization burden, although prospective external validation is required.
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3. Vitamin D deficiency, depression severity, and suicide risk: evidence from patients with major depressive disorder.
PMID:日期:2026-07-01Major depressive disorder (MDD) is a common psychiatric condition characterized by depressive symptoms and suicide-related clinical features. Vitamin D status has been investigated as a potential clinical correlate of depression and suicidal ideation, but the direction and specificity of these associations remain uncertain. This cross-sectional study aimed to examine the associations among serum 25-hydroxyvitamin D [25(OH)D] levels, depressive symptom severity, suicidal ideation, and suicide-related cognitive-affective dimensions in adults diagnosed with MDD. This cross-sectional study included 97 adults aged 18-65 years who were diagnosed with MDD according to DSM-5 criteria. Depressive symptom severity and suicide-related outcomes were assessed using the Hamilton Depression Rating Scale (HDRS), Suicidal Ideation Scale (SIS), and Suicide Probability Scale (SPS). Vitamin D status was classified as deficient (<20 ng/mL), insufficient (20-29 ng/mL), or sufficient (≥30 ng/mL). Associations were examined using multivariable generalized linear models adjusted for available sociodemographic and clinical covariates. Vitamin D deficiency was observed in 61.9% of participants and the mean serum 25(OH)D level was 18.4 ± 11.9 ng/mL. Lower serum 25(OH)D levels were significantly associated with higher HDRS, SIS, and SPS total/subscale scores. In adjusted models, higher serum 25(OH)D levels remained inversely associated with HDRS scores, SIS scores, and total SPS scores. Parental status was also associated with lower SIS scores, while a history of suicide attempts was associated with higher SPS-Suicidal Ideation scores. Lower serum 25(OH)D levels were associated with greater depressive symptom severity and higher suicide-related scale scores in adults with MDD, particularly across cognitive-affective domains relevant to suicide probability. However, given the study's cross-sectional single-center design, absence of a healthy control group, modest sample size, and adjustment limited to available covariates, these findings should be interpreted as associations rather than evidence of causality, directionality, or established biomarker utility.
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4. {"_":" gene variants p.(Asp165Glu) and p.(Asn614ThrfsTer2) in pediatric cryptorchidism: a hypothesis-generating pilot case-control study from the Eastern Black Sea region of Türkiye.","i":["DAAM2"]}
PMID:日期:2026-06-30Cryptorchidism is the most common congenital anomaly of the male genitourinary system, characterized by a multifactorial etiology. The disheveled-associated activator of morphogenesis 2 () gene regulates androgen receptor (AR)-dependent transcription; its variants are associated with partial androgen insensitivity. Since the inguinoscrotal phase of testicular descent is androgen-dependent, we hypothesized that variants contribute to cryptorchidism susceptibility. This pilot study, designed to generate hypotheses rather than to establish association, investigated the frequency of two functionally characterized variants, p.(Asp165Glu) and p.(Asn614ThrfsTer2), in pediatric cryptorchidism. This prospective case-control study included 40 male pediatric cryptorchidism patients and 39 age- and sex-matched healthy male controls. Genomic DNA was extracted from peripheral blood. The p.(Asp165Glu) variant was genotyped by TaqMan allelic discrimination and p.(Asn614ThrfsTer2) by ARMS-PCR with melting curve analysis. Genotype distributions were compared using linear-by-linear association testing with exact p-values, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by binary logistic regression. Heterozygous p.N614Tfs*2 carriage was more frequent in cryptorchidism patients (12.5%, n = 5) than in controls (2.6%, n = 1), with an unadjusted OR of 5.43 (95% CI: 0.6048.78, p = 0.131). Heterozygous p.D165E frequency was similar in both groups (7.5% vs. 7.7%; OR: 1.03, 95% CI: 0.19-5.45, p = 0.974), whereas homozygous p.D165E was identified exclusively in 2 of 40 cryptorchidism patients (5.0%) and in none of the controls, resulting in complete separation in the regression model. Although statistical significance could not be reached due to the limited size of the study group, the observed fivefold increase in heterozygosity of p.(Asn614ThrfsTer2) and the presence of homozygosity of p.(Asp165Glu) in cryptorchidism cases contribute to the literature. These data suggest that variants may play a potential role in the etiology of cryptorchidism.
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5. Transient bacteremia during coblation-assisted tonsillotomy in children.
PMID:日期:2026-06-25The aim of this study was to evaluate the incidence of transient bacteremia after coblation-assisted intracapsular partial tonsillectomy (tonsillotomy) in children. This prospective study included 42 children with grade 3-4 tonsillar hypertrophy who underwent coblation-assisted tonsillotomy for obstructive sleep apnea syndrome. Aerobic and anaerobic blood cultures were obtained preoperatively and immediately after tonsillotomy. Intraoperative throat cultures were also obtained before mucosal manipulation. All preoperative blood cultures were negative. Postoperative blood cultures were positive in two patients (4.8%; 95% CI, 0.6%-16.2%). and spp. were isolated. The patient with bacteremia also had in the corresponding throat culture. No clinical complications related to transient bacteremia were observed. This is the first study on evaluation of transient bacteremia after coblation-assisted tonsillotomy. Although the technique is minimally invasive, transient bacteremia occurred in 4.8% of the children. Antibiotic prophylaxis should be considered individually in patients at high risk for bacteremia-related complications, in accordance with current recommendations.
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6. A hidden danger in cancer patients: intestinal parasites.
PMID:日期:2026-06-12Intestinal parasites are a significant cause of morbidity and mortality in immunosuppressed individuals. This study aimed to evaluate the frequency, distribution, and associated clinical factors of intestinal parasite detection among patients with solid tumors who presented with diarrhea over a 10-year period. This retrospective study included patients aged ≥18 years with solid tumors who presented with diarrhea and had stool samples examined at the Ege University Medical Parasitology Laboratory between January 2014 and September 2024. Patients with incomplete records or inadequate stool processing were excluded. Demographic, clinical, and treatment data were retrieved from electronic medical records and analyzed using SPSS version 22.0 (IBM Corp., Armonk, NY, USA). Among 154 patients (mean age, 57.2 ± 16.3 years; 57.1% female), intestinal parasites were detected in 22.1% of patients (n = 34), with spp. (16.9%) and spp. or the complex (2.6%) being the most frequently identified organisms. spp. showed a borderline, nonsignificant trend toward a higher detection rate among patients with gastrointestinal system (GIS) malignancies (p = 0.067). No clinical or treatment-related variable was significantly associated with overall intestinal parasite detection in either categorical comparisons or univariate logistic regression. However, borderline, nonsignificant trends were observed for GIS malignancy (OR: 1.994; 95% CI: 0.917-4.336; p = 0.079) and recent hospitalization (OR: 0.482; 95% CI: 0.221-1.050; p = 0.066). In patients with available follow-up, clinical improvement was observed after antiparasitic or symptomatic treatment. Among patients with solid tumors presenting with diarrhea, intestinal parasitic infections should be considered in the differential diagnosis. Early parasitological evaluation and increased oncologist awareness may facilitate timely treatment, symptom control, and prevention of complications.
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7. Hearing loss in Behçet's syndrome: prevalence and associated factors in a nationwide cross-sectional analysis.
PMID:日期:2026-06-02The aim of this study was to investigate the prevalence of hearing loss in Behçet's syndrome and its associations with other disease manifestations, comorbidities, and treatment agents. To the best of our knowledge, this is the most comprehensive study to date addressing this issue. The study was designed as a cross-sectional, nationwide study. The Turkish Ministry of Health National Electronic Database (e-Nabız) was used under the supervision of the Ministry of Health to extract patient data. A nationwide cohort was established from patients who had been assigned an ICD-10 code for BS (M35.2) on at least two occasions, separated by a minimum of 3 months, between 1 January 2016, and 31 December 2022, and were therefore considered to have BS. Data on demographics, comorbidities, major disease manifestations other than mucocutaneous and musculoskeletal involvement, and treatment agents ever used for BS were recorded. Within this cohort, patients who had been assigned an ICD-10 code for hearing loss (H90 or H91 and their subcategories) were classified as BS patients with hearing loss. Demographics, clinical characteristics and treatment history were compared between BS patients with and without hearing loss. A total of 84,240 patients with BS were identified and included in the analysis. Among these patients, 976 were identified as having hearing loss; 487 had sensorineural hearing loss, 71 had conductive hearing loss, 46 had mixed hearing loss, and 464 had unspecified hearing loss. In multivariable analysis, none of the BS-related manifestations remained independently associated with hearing loss. However, male sex, age >50 years at the time of analysis, hypertension, coronary artery disease, chronic kidney disease, malignancy, depression, viral hepatitis, asthma, osteoporosis, and treatment with certolizumab pegol were independently associated with an increased risk of hearing loss. In this nationwide study, a prevalence of hearing loss of 1.16% was observed among patients with BS. Our findings suggest that older age and the presence of certain comorbidities, rather than BS-specific manifestations, were associated with hearing loss.
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8. Hounsfield unit thresholds in differentiating adenoma from nonadenoma adrenal masses: a retrospective adrenalectomy-based study.
PMID:日期:2026-06-01Adrenal incidentalomas are increasingly detected during imaging studies performed for various indications, and their frequency in endocrinology practice has risen in recent years. While adenomas account for approximately 80% of adrenal incidentalomas, the remaining 20% include lesions such as primary malignancies, metastases, and pheochromocytomas that should not be overlooked. Given the risks associated with adrenal biopsy, accurate diagnosis with noninvasive methods is essential. In this retrospective study, we evaluated the Hounsfield unit (HU) values and lesion sizes measured on noncontrast computed tomography (CT) to identify a more accurate threshold than the widely used 10 HU. In this retrospective study, patients who underwent unilateral adrenalectomy between 2013 and 2022 were evaluated. Noncontrast CT images were assessed for lesion size and attenuation, and statistical analyses included tests for nonnormally distributed data, logistic regression, and ROC analysis to determine the diagnostic performance of mass size and density in differentiating adenoma from nonadenoma lesions. A total of 106 patients who underwent adrenalectomy for various indications were included, of whom 55 had adenomas and 51 had nonadenoma masses. The mean size of the adenoma versus nonadenoma lesions was 37.2 ± 15 mm and 55.8 ± 30 mm, respectively (p < 0.05), while mean HU values were 11.4 ± 17 and 35.9 ± 14, respectively (p < 0.05). The ROC analysis showed that HU values exhibited strong discriminative ability in distinguishing adenoma from nonadenoma masses (AUC = 0.869). According to Youden's index, 20 HU was identified as the optimal threshold value. The sensitivity/specificity values for 10 HU, 15 HU, and 20 HU were 98%/56%, 98%/61%, and 92%/82%, respectively. Within this selected adrenalectomy cohort, adopting a 20 HU threshold instead of the conventional 10 HU value significantly improved specificity in differentiating adenomas from nonadenomas. However, broader prospective validation in unselected incidentaloma populations is warranted before recommending a definitive change in routine clinical guidelines.
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9. Perioperative effects of the quadratus lumborum block in percutaneous biliary drainage: a prospective randomized controlled study.
PMID:日期:2026-06-01The aim of this study was to evaluate the effect of the quadratus lumborum block (QLB) on intraoperative opioid consumption in patients undergoing percutaneous biliary drainage (PBD). A total of 57 patients who met the inclusion criteria were randomized into two groups: the sedation group (Group 1, n = 26) and the sedation with QLB group (Group 2, n = 26). The groups were compared in terms of intraoperative anesthetic consumption, vital parameters, postanesthesia care unit (PACU) recovery times, postoperative visual analog scale (VAS) scores, postoperative analgesic consumption, and clinician and patient satisfaction. The study was entered into the ClinicalTrials.gov database (Identifier: NCT06618781). Demographic characteristics and anesthesia and surgical durations were comparable between the two groups (p > 0.05). Intraoperative total propofol and remifentanil consumption was significantly lower in Group 2 (p < 0.001). The incidence of complications was comparable between the groups (p > 0.05). Intraoperative hemodynamic stability was assessed by comparing heart rate (p > 0.05), systolic blood pressure (p = 0.043), diastolic blood pressure (p > 0.05), mean arterial pressure (p > 0.05), and end-tidal carbon dioxide (p > 0.05). Group 2 was found to be more stable in terms of systolic blood pressure. PACU recovery times were significantly shorter in Group 2 (p = 0.002). Postoperative VAS scores at the 2nd, 6th, 12th, and 24th hours, as well as the need for rescue analgesics, were significantly lower in Group 2 (p < 0.001). Clinician and patient satisfaction scores were significantly higher in Group 2 (p < 0.001). The current findings suggest that the incorporation of QLB into anesthetic management for PBD procedures may improve perioperative outcomes by reducing intraoperative opioid requirements without an associated increase in complication rates.
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10. Preserved inflammatory homeostasis during emergency transport: a multibiomarker assessment of neonatal RDS transfers.
PMID:日期:2026-05-31The aim was to compare the pre- and posttransport levels of systemic inflammatory markers in neonatal infants transported to a tertiary intensive care unit via emergency health services with a neonatal respiratory distress syndrome (nRDS) diagnosis and to assess the quality of transport. This retrospective study was conducted between January 2019 and December 2023. A total of 117 nRDS patients' emergency transports were included in the study. Demographic data, transfer time, intubation, cold treatment, cardiopulmonary resuscitation (CPR), and pre- and posttransport laboratory parameters were obtained retrospectively. The statistical analysis was performed using IBM SPSS Statistics (Version 22.0), with a significance level of p < 0.05. The mean gestational age at birth was 35.46 ± 4.189 weeks. Among the neonates transported, 41.9% (n = 49) were intubated and 41.9% (n = 49) required mechanical ventilation during transport. CPR was performed in 12.8% (n = 15) of cases, with 4.3% (n = 5) requiring prolonged CPR. The mortality rate was 11.1% (n = 13). The mean neutrophil-to-lymphocyte ratio (NLR) was 3.0 ± 3.40, the platelet-to-lymphocyte ratio (PLR) was 101.2 ± 103.9, the systemic inflammatory index (SII) (×10) was 1.91 ± 2.43, and the haemoglobin, albumin, lymphocyte, platelet (HALP) score was 10.42 ± 21.36. No statistically significant differences were observed between the pre- and posttransfer values of the NLR, PLR, HALP index, or SII (overall p > 0.05). No significant differences were detected between pre- and posttransport inflammatory marker levels. These findings suggest that the transport process may not be associated with a measurable inflammatory response, possibly reflecting the effectiveness of appropriate treatment and stabilisation during transport.