GENERAL AND COMPARATIVE ENDOCRINOLOGY普通与比较内分泌学
GENERAL AND COMPARATIVE ENDOCRINOLOGY(英文缩写 GEN COMP ENDOCR),ISSN 0016-6480,eISSN 1095-6840,中文译名:普通与比较内分泌学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.255 | Q3 |
| 2022 | 2.700 | Q4 |
| 2023 | 2.100 | Q1 |
| 2024 | 1.700 | Q2 |
| 2025 | 2.100 | Q1 |
GENERAL AND COMPARATIVE ENDOCRINOLOGY 最新收录文献
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1. Non-invasive hormone monitoring in free-ranging Weddell seals (Leptonychotes weddellii): a tool for remote population assessment.
1. 自由放养的威德尔海豹（Leptonychotes weddellii）的非侵入性激素监测：一种远程种群评估工具PMID:日期:2026-10-02The presence and the activities of humans can have negative effects on other species, the impacts of which can be seen as changes in biomarkers such as steroid hormones. However, a detailed understanding of endocrine function is lacking in many species, especially wild populations living in remote localities. We provide the first evidence of concurrent and progressive hormone changes from the winter pre-breeding to the summer breeding period for Weddell seals (Leptonychotes weddellii) in East Antarctica. To do so we validated a non-invasive approach to quantify faecal metabolites of testosterone (fTM), progesterone (fPM), and estradiol (fEM). Minimum fTM concentrations were at least four times higher in samples from adult males than from a male pup, and female fPM concentrations were significantly higher when pregnant females were present, indicating that the assays can detect biologically relevant changes in circulating hormones. There were clear seasonal patterns for both sexes. In females, fEM and fPM levels increased during the pupping period and declined to baseline after the last female gave birth. In males, fTM increased during the breeding season while they were defending territories and mating with females. Our results suggest faecal hormone analysis can be a useful monitoring tool for Weddell seals and provide baseline information about temporal changes in hormone expression. In the future, this may be a useful tool for monitoring the effects of increased human activity on Weddell seal populations and applicable to other species.
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2. Estradiol predicts pausing during mate-choice updating in a stress-buffered treefrog.
2. 雌二醇预测处于压力缓冲状态下的树蛙在配偶选择更新过程中的暂停行为PMID:日期:2026-09-24Acute environmental stressors elevate circulating glucocorticoids on timescales of minutes to hours, raising the question of whether transient hypothalamic-pituitary-adrenal/interrenal (HPA) activation disrupts reproductive function during the brief breeding windows of seasonally breeding vertebrates. The conventional HPA-HPG crosstalk model predicts glucocorticoid-induced suppression of gonadal hormones and reproductive behavior, but seasonal breeders such as many frogs may be buffered against acute glucocorticoid elevation during peak reproductive readiness. Using an experimental cohort of Cope's gray treefrogs (Hyla chrysoscelis), we measured plasma 17β-estradiol (E) and tested a primary prediction of the buffering hypothesis: that acute corticosterone (CORT) manipulation will not suppress circulating E. We then explored whether endogenous E covaried with mate-choice behavior in unmanipulated control females. Acute CORT manipulation did not alter circulating E, even at doses that increased plasma CORT by an order of magnitude, supporting the buffering hypothesis. Exploratory analyses revealed two complementary patterns: endogenous E did not predict broad outcomes of mate choice (sexual proceptivity, locomotor effort, choice reversal probability, or initial preference for longer calls), but was positively associated with the duration of pauses made specifically at moments of decision reversal. Together, these findings support buffering of the female HPG axis against acute HPA activation during reproductive readiness while identifying decision deliberation as a fine-grained behavioral dimension that retains hormonal sensitivity during peak reproductive readiness.
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3. Mechanisms underlying the cortisol response to acute warming in a freshwater teleost fish.
3. 淡水硬骨鱼急性升温下皮质醇反应的机制PMID:日期:2026-09-23Although acute warming is well known to increase circulating concentrations of the glucocorticoid stress hormone cortisol in fishes, the mechanisms through which fish perceive high temperatures as a stressor and activate the hypothalamic-pituitary-interrenal (HPI) axis remain poorly understood. Here, we probed these mechanisms using measurements of the cortisol response to thermal ramping, cortisol production by isolated head kidney preparations, and transcript abundances of key genes of the HPI axis. Rainbow trout mounted a significant (4.4-fold increase over baseline) cortisol response to thermal ramping at 27 °C. This 'threshold' temperature was lowered to 25 °C by 4 d of cortisol treatment and raised to 29 °C by acclimation to warmer (22 °C) water. Although transcript abundances of most HPI axis genes were unaffected by thermal ramping, expression of the steroidogenic factor (SF-1) paralogue ff1d was significantly higher (∼3.1-fold) in trout exposed to thermal ramping to 27 °C. Treatment with the TRPV1 antagonist capsazepine decreased both the cortisol response to thermal ramping at 27 °C and crf transcript abundance; activation of TRPV1 using capsaicin was without effect. Together with the observation that adrenocorticotropic hormone (ACTH)-stimulated cortisol production in vitro was not affected by increasing incubation temperature, these findings demonstrate plasticity in the HPI axis response to temperature and implicate TRPV1 as a thermosensor linked to HPI axis activation. Moreover, the heightened thermal sensitivity of cortisol-treated trout suggests that fish experiencing chronic stress will be more vulnerable to climate warming and other related challenges.
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4. Hepatocyte nuclear factor 4 binds to a putative regulatory element in the major yolk protein gene promoter of the sea urchin Mesocentrotus nudus.
PMID:日期:2026-09-18In sea urchins, major yolk protein (MYP) is a key nutrient-storage protein that is important for gonadal nutrient accumulation and gametogenesis in both sexes. Although nuclear receptors have been implicated in the transcriptional regulation of myp, the underlying regulatory mechanisms remain largely unresolved. In this study, we evaluated the role of hepatocyte nuclear factor 4 (HNF4), a nuclear receptor with a putative binding motif in the promoter region of Mesocentrotus nudus myp identified through an in silico analysis. We cloned the open reading frame (ORF) of M. nudus hnf4. The cloned ORF encoded a 494-amino-acid protein that clustered with members of the HNF4 subfamily, and its DNA-binding domain showed high conservation across species. In male and female gonads, M. nudus hnf4 mRNA levels were positively correlated with levels of M. nudus myp. An immunofluorescence analysis showed that M. nudus HNF4 was localized in nutritive phagocytes, including the nuclei, in both ovaries and testes. Electrophoretic mobility shift assays further supported the possibility that M. nudus HNF4 binds to a canonical Direct repeat 1 (DR-1) element and to the HNF4-like element identified in the myp promoter. These findings identify HNF4 as a candidate transcriptional regulator of sea urchin myp.
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5. Creb function is critical for hypoxia/reoxygenation-induced catch-up growth and the associated maintenance of neural crest cells in zebrafish embryos.
PMID:日期:2026-09-18Animal growth progresses under favorable conditions; however, it slows when environmental conditions deteriorate. Conversely, when unfavorable conditions are removed, growth accelerates, and underdeveloped animals rapidly catch up to age-equivalent body size. This process is known as "catch-up growth", yet its molecular mechanisms are not fully understood. Zebrafish embryos temporarily exposed to hypoxia followed by reoxygenation exhibit catch-up growth, and mitogen-activated protein kinase (Mapk) signaling plays essential roles in this growth spurt. Here, we show that a Mapk-target transcription factor, cAMP response element-binding protein (Creb), is indispensable for catch-up growth. Pharmacological inhibition of Creb significantly slowed the reoxygenation-induced catch-up growth but had a limited effect on normal growth in embryos that had never experienced hypoxia/reoxygenation. Although Creb had only a minor effect on cell proliferation, it significantly affected the expression of genes involved in the maintenance and differentiation of neural crest cells (NCCs) and their derivatives in the reoxygenated embryos. In addition, continued Creb blockade clearly affected the growth of pharyngeal and mandibular skeletons, which are largely derived from cranial NCCs. The effect of Creb inhibition on skeletal formation in reoxygenated fish was greater than that observed in normally developed fish. Furthermore, RNA-seq analysis of isolated NCCs, followed by pathway analysis and gene set enrichment analysis, predicted Creb as an indispensable molecule contributing to reoxygenation-specific gene expression in NCCs of the catching-up embryos. These results reveal a previously unknown role for Creb in NCCs and suggest that this role is critical for embryonic catch-up growth in response to environmental oxygen fluctuations.
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6. Transcriptional regulation of the membrane progestin receptor α gene PAQR7 underlying progesterone responsiveness in sperm storage tubules of Japanese quail.
6. 日本鹌鹑精子储存小管中膜孕激素受体α基因PAQR7的转录调控及其对孕酮响应性的影响PMID:日期:2026-09-15In birds, sperm storage tubules (SSTs) located at the uterovaginal junction (UVJ) facilitate long-term sperm storage and regulate sperm release in coordination with ovulation. In Japanese quail (Coturnix japonica), sperm release from SSTs might be mediated by membrane progestin receptor α (mPRα), encoded by the progestin and adipoQ receptor family member 7 (PAQR7) gene. Although PAQR7 plays an important role in reproductive functions, the mechanisms regulating its transcription remain unclear. Therefore, in this study, we investigated the transcriptional regulatory mechanisms of PAQR7 in Japanese quail SSTs. Reporter assays using serial deletion constructs identified multiple positive and negative regulatory regions within the 5' upstream region of PAQR7. Analysis of the proximal promoter region revealed a putative initiator element and non-canonical promoter structure. Electrophoretic mobility shift assays identified several nuclear protein-binding regions within the upstream regulatory region. Candidate transcription factors potentially binding to these regions were predicted using JASPAR and RNA-Seq transcriptome data. Quantitative PCR further revealed that FOS, JUN, FOXN1, and SOX17 levels were significantly upregulated in SST-containing tissues compared to those in non-SST epithelial tissues. Overall, our findings suggest that PAQR7 expression in SSTs is regulated by an SST-specific transcriptional environment involving activator protein-1 (AP-1; FOS-JUN complex), JUN, FOXN1, and SOX17. These findings provide new insights into the transcriptional regulation of progesterone responsiveness in avian reproductive tissues and advance our understanding of endocrine mechanisms underlying sperm storage.
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7. FKBP5 expression in Peromyscus leucopus reflects land cover and climate predictability.
PMID:日期:2026-09-15Anthropogenic activities such as urbanization, agricultural expansion, and climate change create landscapes of stress for wildlife. In vertebrates, neurophysiological stress responses are regulated by the hypothalamic-pituitary-adrenal (HPA) axis, with the co-chaperone FKBP5, playing a key role in modulating glucocorticoid receptor (GR) sensitivity through negative feedback. Variation in FKBP5 expression influences how individuals cope with stressors (i.e., endocrine flexibility): lower FKBP5 expression is associated with more efficient activation and termination of stress responses, whereas higher expression weakens negative feedback and prolongs HPA-axis activity. Here, we examined how FKBP5 expression in blood relates to land cover (e.g., natural and anthropogenic) and climate predictability (Colwell's indices of temperature and precipitation) in white-footed mice (Peromyscus leucopus), a non-commensal rodent that serves as the primary reservoir host for Borrelia burgdorferi. Using samples from 126 mice captured across 12 NEON (National Ecological Observatory Network) sites and characterizing land cover composition using principal component analysis (PC1 captured 54% of variance, loading positively for tree cover and negatively for grass, cropland, shrub, and built cover), we found forest-dominant sites (higher PC1) predicted elevated FKBP5 expression in blood. We also found that sites with increasingly predictable precipitation predicted lower FKBP5 expression, indicating greater endocrine flexibility being favored in predictable environments. While unexpected, the positive association between FKBP5 expression and increasing tree cover suggests natural P. leucopus habitat may induce prolonged HPA activation due to local ecological conditions such as predation or competition. Future work should address how individuals vary in FKBP5 over time and during stressful events.
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8. Integrating genomics and endocrinology to investigate prolactin dysregulation in female African Savannah elephants housed in north American zoos.
8. 整合基因组学与内分泌学，研究北美动物园饲养的雌性非洲草原象的催乳素失调问题PMID:日期:2026-09-15The sustainability of the captive African savannah elephant (Loxodonta africana) population in the United States has reached a critical point and is no longer viable under current conditions. A major contributing factor is the high proportion of reproductively aged female African savannah elephants that are not cycling due to prolactin dysregulation (hyperprolactinemia). Because prolactin secretion plays a key role in normal ovarian function in mammals, its dysregulation can negatively affect both individual health and overall reproductive success. No treatments for this condition are currently known in elephants. We conducted a genome-wide association study (GWAS) to identify genomic variants associated with hyperprolactinemia in a cohort of 95 female African elephants in the North American zoo population; however, no variants were significantly associated with either cyclicity or prolactin status. Potential reasons for this outcome include limited sample size, genetic heterogeneity of the trait, and complex interactions between environment and reproductive outcomes. The lack of significant SNP associations underscores the complexity of prolactin dysregulation in elephants and the need for larger, more comprehensive studies, including the investigation of DNA methylation and gene expression to assess environmental or social influences on gene expression. These findings provide a foundation for future research on prolactin disorders in African elephants.
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9. Long-term thermal challenge increases cortisol accumulation and enhances negative feedback regulation of the HPI axis in the European seabass (Dicentrarchus labrax).
9. 长期热应激会增加欧洲海鲈（Dicentrarchus labrax）中皮质醇的积累，并增强HPI轴的负反馈调节PMID:日期:2026-09-12As ectotherms, fishes are particularly sensitive to rising temperatures, which can alter physiological regulation, including stress responses. Previous studies have shown that temperature can modulate multiple molecular components of the hypothalamus-pituitary-interrenal (HPI) axis, which regulates cortisol production, the primary stress hormone in fishes. In this study, we investigated how long-term rearing under a control or a warm seasonal thermal regime modulated both the basal activity of the HPI axis throughout development, and its responsiveness to acute stress at a specific life stage in the European seabass (Dicentrarchus labrax). HPI-related gene expressions were developmentally structured and their thermal regulation occurred even at early life stage (i.e. all-fins). At later life stages (one- and two-year-old fish), an overall pattern emerged, indicating a general downregulation of key genes expression, espacially mr, in the warm regime, consistent with a negative feedback regulation of the HPI axis under prolonged thermal exposure. Fish reared in the warm regime also exhibited higher cortisol levels in scales mainly at two years of age, indicating sustained glucocorticoid exposures under this condition. Finally, following an acute confinement stress exposure, one-year-old fish reared in the warm regime exhibited an amplified cortisol response, suggesting exacerbated HPI-axis reactivity at elevated temperatures. Our findings provide new insights into how warming shapes molecular regulation and stress responsiveness of the stress physiology in ectotherms.
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10. Glycoprotein hormone GPA2/GPB5: discoveries and insights from invertebrates.
10. 糖蛋白激素GPA2/GPB5：无脊椎动物的发现和见解PMID:日期:2026-09-11Vertebrate thyrostimulin and the other classical pituitary glycoprotein hormones are considered to have originated from a common ancestral hormone system early in Metazoan evolution. The invertebrate glycoprotein hormone, GPA2/GPB5, is the homolog of vertebrate thyrostimulin, and the only member of these glycoprotein hormones to be found in invertebrates. This review focuses on the GPA2/GPB5 signaling pathway in invertebrates, outlining its evolutionary origin and conservation, discovery, distribution, including receptor localization, and physiological relevance. Although the physiological roles of GPA2/GPB5 in invertebrates have only recently been investigated, the emerging evidence supports functions like that in the vertebrates, namely stress responses, development, and reproduction. In particular, the signaling pathway appears to act as an endocrine "switch" to integrate complex physiological processes.