缺乏证据表明EB病毒在肺和胸膜肿瘤中具有病因学作用

摘要(中文译文)

尽管大多数肺癌和间皮瘤都与已知的危险因素相关，但这些癌症仅在接受已知危险因素暴露的少数人群中发生。另一方面，这些癌症也在一些未暴露于已知危险因素的患者中发生。这表明其他环境因素在这些肿瘤的癌变过程中发挥作用。致癌病毒如EB病毒（Epstein-Barr virus，EBV）是某些癌症发生的公认病原体。通过原位杂交技术，已在胃腺癌和鼻咽癌中检测到EBV基因组。为确定EBV感染是否与肺腺癌或间皮瘤相关，我们对80例肺腺癌和50例间皮瘤切除标本进行了EBV编码RNA-1原位杂交检测。从石蜡包埋组织中切片，使用反义寡核苷酸探针进行EBV编码RNA-1原位杂交。对切片进行审阅，观察肿瘤细胞中EBV编码RNA-1的存在情况。全部80例腺癌和50例间皮瘤经原位杂交检测，EBV编码RNA-1均为阴性。总之，本研究未发现EBV在肺腺癌或胸膜间皮瘤发生中具有病因学作用的证据。

Abstract

Although most lung carcinomas and mesotheliomas are associated with well-known risk factors, these cancers develop in only a minority of persons exposed to known risk factors. On the other hand, these cancers develop in some patients without exposure to known risk factors. This indicates that other environmental factors play a role in the carcinogenesis of these tumors. Oncogenic viruses such as Epstein-Barr virus (EBC) are well-established agents in the development of certain cancers. EBV genomes have been detected by in situ hybridization in gastric adenocarcinomas and in nasopharyngeal carcinomas. To determine whether EBV infection is associated with pulmonary adenocarcinoma or mesothelioma, we performed EBV-encoded RNA-1 in situ hybridization on 80 pulmonary adenocarcinoma and 50 mesothelioma resection specimens. Sections were cut from paraffin-embedded tissue and EBV-encoded RNA-1 in situ hybridization was performed using an antisense oligoprobe. Sections were reviewed for the presence of EBV-encoded RNA-1 in tumor cells. All 80 adenocarcinomas and 50 mesotheliomas were negative for EBV-encoded RNA-1 by in situ hybridization. In conclusion, no evidence for an etiologic role for EBV in the development of pulmonary adenocarcinoma or pleural mesothelioma was found in this study.

如何引用

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 的其他文献

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