含有香桃木提取物的明胶/羧甲基纤维素水凝胶的设计及其抗炎能力用于加速伤口愈合；体外和体内研究

摘要(中文译文)

在损伤后实现最佳的皮肤完整性需要使用具有理想水凝胶特性的伤口敷料。本研究旨在开发一种主要以明胶和羧甲基纤维素（GEL/CMC）为原料的水凝胶。我们将香桃木（Myrtus communis）提取物掺入水凝胶中，以评估其对全层伤口的愈合效果。该植物提取物作为炎症调节因子，促进增殖和促血管生成因子，而天然聚合物则支持这些过程。香桃木和水凝胶的表征涉及多种方法，包括力学性能、形态学、血液相容性、细胞毒性以及动物实验的评估。该水凝胶呈现多孔结构，孔隙相互连通，平均孔径为119.73 ± 13.67。其在48小时内还具有高达自身初始重量90%的溶胀能力。该水凝胶还表现出生物相容性和血液相容性特征。在最后阶段，动物模型中的伤口愈合评估显示，使用合成水凝胶极大地促进了愈合过程（伤口面积闭合率：88.73 ± 3.95%）。总之，该支架在促进组织再上皮化和再生方面显示出良好前景，使其成为改善皮肤伤口愈合的高度理想选择。

Abstract

Achieving optimal skin integrity after an injury requires using a wound dressing with desirable hydrogel properties. This study aims to develop a hydrogel primarily made from gelatin and carboxymethyl cellulose (GEL/CMC). We incorporated Myrtus communis extract into the hydrogel to evaluate its healing effect on full-thickness wounds. The plant extract acts as a regulator of inflammation, promoting proliferation and pro-angiogenic factors, while the natural polymers support these processes. The characterization of Myrtus communis and the hydrogel involved various methods, including assessments of mechanical properties, morphology, hemocompatibility, cytotoxicity, and animal testing. The hydrogels exhibited porous designs with interconnected pores, with a mean size of 119.73 ± 13.67. They also showed a swelling capability of up to 90% of their starting weight within 48 h. The hydrogels also demonstrated both biocompatibility and hemocompatibility characteristics. In the final phase, the assessment of wound healing in the animal model revealed that using the synthesized hydrogels greatly enhanced the healing process (closure of the wound area: 88.73 ± 3.95%). In summary, this scaffold has shown promise in promoting tissue re-epithelialization and regeneration, which makes it a highly favorable option for improving the healing of skin wounds.

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