结肠癌中的干性
Stemness in Colon Cancer.
摘要(中文译文)
细胞可塑性是结直肠癌（CRC）的主要驱动因素，因为肿瘤劫持肠道干细胞再生程序，在互补的干细胞样状态之间形成动态的双向轴。癌症干细胞样细胞（CSC）表现出标志性的干细胞特性，包括自我更新、多能性、受控分化和静息状态，目前已被认为是CRC生物学的关键调控者。它们能够维持肿瘤起始和长期生长、播散转移、实现休眠期以及促进化疗耐药。因此，从治疗角度瓦解CSC群体及其支持性微环境，是改善治疗反应并最终提高患者生存率的一项极具吸引力的策略。
Abstract
Cell plasticity is a major driver of colorectal cancer (CRC), as tumors hijack intestinal stem cell regenerative programs to create a dynamic, bidirectional axis between complementary stem-like states. Cancer stem-like cells (CSCs) display hallmark stem cell properties, including self-renewal, multipotency, controlled differentiation, and quiescence, and are now recognized as key orchestrators of CRC biology. They can sustain tumor initiation and long-term growth, seed metastases, enable periods of dormancy, and promote resistance to chemotherapy. As a result, therapeutically dismantling CSC populations and their supportive niches offers a compelling strategy to improve treatment responses and ultimately patient survival.
如何引用
AMA
Roei Cohen-Almagor, Samna Sagadevan, Paloma Ordóñez-Morán. Stemness in Colon Cancer.. Methods in molecular biology (Clifton, N.J.). 2027; doi:10.1007/978-1-0716-5412-5_19.
APA
Roei Cohen-Almagor, Samna Sagadevan, Paloma Ordóñez-Morán (2027). Stemness in Colon Cancer.. Methods in molecular biology (Clifton, N.J.). https://doi.org/10.1007/978-1-0716-5412-5_19
GB/T 7714
Roei Cohen-Almagor, Samna Sagadevan, Paloma Ordóñez-Morán. Stemness in Colon Cancer.[J]. Methods in molecular biology (Clifton, N.J.), 2027 doi:10.1007/978-1-0716-5412-5_19.
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