两种仿生再矿化系统对人工脱矿牙釉质的影响：矿物恢复与正畸托槽粘接强度的评估
Effect of two biomimetic remineralizing systems on artificially demineralized enamel: Assessment of mineral recovery and orthodontic bracket bond strength.
摘要(中文译文)
评估两种再矿化系统（Regenerate™和Orthocare™）对脱矿牙釉质矿物质恢复及托槽剪切粘结强度（SBS）的影响。将180颗牛牙分为四组：1）完整牙釉质，2）脱矿牙釉质，3）脱矿牙釉质/Regenerate™处理，4）脱矿牙釉质/Orthocare™处理。第2至4组进行脱矿处理。所有样本每日刷牙三次；第1组和第2组不使用牙膏，第3组和第4组分别使用Regenerate™或Orthocare™处理。通过剪切粘结强度、粘接剂残留面积、场发射扫描电子显微镜（FE-SEM）、能量色散X射线光谱（EDX）、拉曼光谱、表面显微硬度和微计算机断层扫描（micro-CT）评估结果。根据数据分布选择参数检验或非参数检验（α = 0.05）。脱矿牙釉质的剪切粘结强度、粘接剂残留、表面显微硬度、矿物质密度、钙磷含量及磷酸盐相关拉曼参数均显著低于完整牙釉质（p < 0.05）。FE-SEM显示孔隙率增加。与未经处理的脱矿牙釉质相比，两种再矿化系统均未显著恢复剪切粘结强度。然而，两种处理均促进了牙釉质的部分再矿化，改善了钙（Ca）和磷（P）水平（p < 0.001），提高了表面显微硬度和矿物质密度（p < 0.05）。拉曼光谱显示，Regenerate™组磷酸盐（I）和碳酸盐（I）峰恢复程度更大，表明其矿化程度和结晶度恢复优于Orthocare™。两种制剂均能部分再矿化牙釉质，但未能完全恢复健康牙釉质的特性。Regenerate™的矿物质恢复效果优于Orthocare™。然而，新形成的羟基磷灰石显得不成熟，且与脱矿牙釉质相比，粘结强度未显著改善。再矿化制剂可在正畸粘接前改善脱矿牙釉质，而不显著影响托槽粘结强度。
Abstract
To evaluate the effect of two remineralizing systems (Regenerate™ and Orthocare™) on the mineral recovery of demineralized enamel and on the shear bond strength (SBS) of brackets. 180 bovine teeth were divided into four groups: 1)Intact enamel, 2)Demineralized enamel, 3)Demineralized enamel/Regenerate™, and 4)Demineralized enamel treated/Orthocare™. Groups 2 to 4 were demineralized. All samples were brushed three times daily; groups 1 and 2 without toothpaste, and groups 3 and 4 were treated with Regenerate™ or Orthocare™. Outcomes were assessed by SBS, adhesive remnant area, field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, surface microhardness, and micro-computed tomography (micro-CT). Parametric or non-parametric tests according to data distribution (α = 0.05). Demineralized enamel showed significantly lower SBS, adhesive remnant, surface microhardness, mineral density, calcium and phosphorus content, and phosphate-related Raman parameters than intact enamel (p < 0.05). FE-SEM revealed increased porosity. Neither remineralizing system significantly restored SBS compared with untreated demineralized enamel. However, both treatments promoted partial enamel remineralization, improved calcium (Ca) and phosphorus (P) levels (p < 0.001), increasing surface microhardness and mineral density (p < 0.05). Raman showed greater recovery of phosphate (I) and carbonate (I) peaks in the Regenerate™ group, indicating better mineralization and crystallinity recovery than Orthocare™. Both agents partially remineralized enamel without fully restoring sound enamel properties. Regenerate™ demonstrated better mineral recovery than Orthocare™. However, the newly formed hydroxyapatite appeared immature, and bond strength was not significantly improved compared with demineralized enamel. Remineralizing agents may improve demineralized enamel before orthodontic bonding without significantly affecting bracket bond strength.
如何引用
AMA
Ascensión Vicente, Antonio J Ortiz-Ruiz, Clara Serna-Muñoz, Inmaculada Cabello, Yolanda Martínez-Beneyto. Effect of two biomimetic remineralizing systems on artificially demineralized enamel: Assessment of mineral recovery and orthodontic bracket bond strength.. Clinical oral investigations. 2026; doi:10.1007/s00784-026-07130-0.
APA
Ascensión Vicente, Antonio J Ortiz-Ruiz, Clara Serna-Muñoz, Inmaculada Cabello, Yolanda Martínez-Beneyto (2026). Effect of two biomimetic remineralizing systems on artificially demineralized enamel: Assessment of mineral recovery and orthodontic bracket bond strength.. Clinical oral investigations. https://doi.org/10.1007/s00784-026-07130-0
GB/T 7714
Ascensión Vicente, Antonio J Ortiz-Ruiz, Clara Serna-Muñoz, Inmaculada Cabello, Yolanda Martínez-Beneyto. Effect of two biomimetic remineralizing systems on artificially demineralized enamel: Assessment of mineral recovery and orthodontic bracket bond strength.[J]. Clinical oral investigations, 2026 doi:10.1007/s00784-026-07130-0.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出