m6A RNA甲基化与蛋白质翻译后修饰的相互调控：对疾病发病机制和治疗的意义
{"_":"Reciprocal regulation of mA RNA methylation and protein post-translational modifications: implications for disease pathogenesis and therapy.","sup":["6"]}
摘要(中文译文)
N6-甲基腺苷（m6A）是RNA中一种普遍存在的表观转录修饰，对RNA代谢和生物发生至关重要。越来越多的证据揭示了m6A与蛋白质翻译后修饰（PTMs）——即在新生蛋白质生物合成过程中或之后对其进行的化学基团共价添加或结构改变——之间存在复杂的相互作用。这种交互作用通过改变蛋白质特性和功能，参与疾病发展和药物反应。然而，关于m6A与PTMs交互作用的作用及机制的综合讨论仍然有限。在此，我们对疾病和治疗反应中这一新兴且复杂的交互作用进行了最新综述。我们首先总结了m6A与泛素化、乳酰化、乙酰化、磷酸化和甲基化等PTMs之间的交互作用，并围绕m6A的三大调控因子——写入器（writers）、擦除器（erasers）和阅读器（readers）——组织讨论。接下来，我们探讨了m6A-PTMs交互作用参与疾病发病机制和发展的机制，包括多种癌症、代谢紊乱和炎症性疾病。此外，我们讨论了m6A-PTMs交互作用在药物反应中的作用，重点关注化疗药物。总之，本综述为理解m6A-PTMs交互作用在疾病发病机制、发展和治疗反应中的调控网络提供了框架，强调了基于这一交互作用的潜在治疗策略，并提出了未来的研究方向。
Abstract
N-methyladenosine (mA) is a prevalent epitranscriptional modification in RNA that is crucial for RNA metabolism and biogenesis. Accumulating evidence reveals a complex interplay between mA and protein post-translational modifications (PTMs)-covalent additions of chemical groups or structural alterations to nascent proteins during or after biosynthesis. This crosstalk involves in disease development and drug response by altering protein properties and functions. However, comprehensive discussion about the roles and mechanisms of mA and PTMs crosstalk is limited. Here, we present an up-to-date review of this emerging and complex interplay in disease and therapeutic response. We first summarize the crosstalk between mA and PTMs such as ubiquitination, lactylation, acetylation, phosphorylation, and methylation, organizing our discussion around the three major regulatory factors mA writers, erasers, and readers. Next, we explore the mechanism of mA-PTMs crosstalk involved in the pathogenesis and development of diseases, including various cancers, metabolic disorders, and inflammatory diseases. Moreover, we discuss the role of mA-PTMs crosstalk in drug response, focusing on chemotherapy drugs. In summary, this review provides a framework for understanding the regulatory networks of mA-PTMs crosstalk in disease pathogenesis, development, and therapeutic response, highlighting potential treatment strategies based on this interplay and suggesting future research directions.
如何引用
AMA
Xinyi Li, Liting Yang, Xianmin Zhou, Gongxing Chen, Shuiping Liu. {"_":"Reciprocal regulation of mA RNA methylation and protein post-translational modifications: implications for disease pathogenesis and therapy.","sup":["6"]}. Biochimica et biophysica acta. Molecular basis of disease. 2027; doi:10.1016/j.bbadis.2026.168446.
APA
Xinyi Li, Liting Yang, Xianmin Zhou, Gongxing Chen, Shuiping Liu (2027). {"_":"Reciprocal regulation of mA RNA methylation and protein post-translational modifications: implications for disease pathogenesis and therapy.","sup":["6"]}. Biochimica et biophysica acta. Molecular basis of disease. https://doi.org/10.1016/j.bbadis.2026.168446
GB/T 7714
Xinyi Li, Liting Yang, Xianmin Zhou, Gongxing Chen, Shuiping Liu. {"_":"Reciprocal regulation of mA RNA methylation and protein post-translational modifications: implications for disease pathogenesis and therapy.","sup":["6"]}[J]. Biochimica et biophysica acta. Molecular basis of disease, 2027 doi:10.1016/j.bbadis.2026.168446.
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