BMAL1-Mediated Circadian Regulation of Oocyte Quality and IVF Outcomes.

摘要(中文译文)

成功的胚胎发育早在受精之前就已在卵巢卵泡精密调控的微环境中展开。越来越多的数据表明，昼夜节律调控系统影响多个决定卵母细胞能力的进程，包括线粒体活性、氧化平衡、减数分裂发育和细胞代谢。脑和肌肉ARNT样蛋白1（BMAL1）作为昼夜节律调控中的关键转录因子，因其在卵巢生理和生殖功能中的重要作用而受到广泛关注。BMAL1信号失调与卵泡发育受损、类固醇生成减少、线粒体功能障碍、氧化应激升高以及减数分裂纺锤体组织异常有关，这些都可能对卵母细胞质量和早期胚胎发育产生负面影响。近期实验和临床研究结果表明，辅助生殖的结果可能受到昼夜节律紊乱、睡眠问题、肥胖、衰老和代谢功能障碍的影响。

Abstract

Successful embryo development transpires far before fertilization inside the meticulously regulated microenvironment of the ovarian follicle. Increasing data indicates that circadian regulatory systems influence several processes that define oocyte competence, including mitochondrial activity, oxidative balance, meiotic development, and cellular metabolism. Brain and muscle ARNT-like protein 1 (BMAL1), an essential transcription factor in circadian regulation, has garnered significant interest due to its crucial involvement in ovarian physiology and reproductive function. Dysregulated BMAL1 signaling has been linked to compromised folliculogenesis, diminished steroidogenesis, mitochondrial dysfunction, elevated oxidative stress, and irregularities in meiotic spindle organization, all of which may negatively impact oocyte quality and early embryo development. Recent experimental and clinical findings indicate that results of assisted reproduction may be influenced by circadian disruption, sleep problems, obesity, ageing, and metabolic dysfunction.

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