在躯体机械治疗中，CPTC通过Wnt轴驱动躯体内脏交流：单细胞深度学习研究
CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study.
摘要(中文译文)
躯体机械刺激（如针刺）可产生全身性免疫调节效应，然而将外周物理力转化为内脏修复的细胞桥梁仍不明确。本研究利用自定义的可解释深度学习框架（CARSS）对单细胞RNA测序数据进行分析，鉴定出CD34PDGFRα端细胞（CPTCs）为细菌性结肠炎期间筋膜和结肠中的主要机械感受器。我们证明，躯体机械治疗触发筋膜CPTCs中AP-1/Hsp70依赖的转录程序，诱导全身性Wnt升高，进而引起结肠CPTCs的“转录共振”，将其通讯网络从炎症放大器重编程为Wnt驱动的再生枢纽。在机制上，该轴激活上皮β-catenin/Myc信号，抑制凋亡并恢复屏障完整性，且不依赖免疫细胞。我们的发现定义了一条CPTC驱动的机械共振轴，其中CPTCs作为同步中继站，将躯体机械刺激转化为全身性再生微环境。
Abstract
Somatic mechanical stimulation (e.g., acupuncture) exerts systemic immunomodulatory effects, yet the cellular bridge translating peripheral physical force into visceral repair remains elusive. Here, employing a custom interpretable deep learning framework (CARSS) on single-cell RNA sequencing data, we identify CD34PDGFRα telocytes (CPTCs) as the primary mechanosensors in both fascia and colon during bacterial colitis. We show that somatic mechanotherapy triggers an AP-1/Hsp70-dependent transcriptional program in fascial CPTCs, inducing systemic Wnt elevation, which elicits a "transcriptional resonance" in colonic CPTCs, reprogramming their communication network from an inflammatory amplifier to a Wnt-driven regenerative hub. Mechanistically, this axis activates epithelial β-catenin/Myc signaling, suppressing apoptosis and restoring barrier integrity independent of immune cells. Our findings define a CPTC-Driven Mechano-Resonance Axis, where CPTCs serve as synchronized relay stations that convert somatic mechanical stimulation into systemic regenerative microenvironments.
如何引用
AMA
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, et al. CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2026; doi:10.1096/fj.202600755RRR.
APA
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, et al (2026). CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.202600755RRR
GB/T 7714
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, et al. CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study.[J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026 doi:10.1096/fj.202600755RRR.
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