一种用于聚焦剪切波瞬态弹性成像的手持式探头
A Handheld Probe for Focused Shear Wave Transient Elastography.
摘要(中文译文)
利用剪切波弹性成像无创评估肝脏硬度常受深部组织中波衰减的限制。我们引入并验证了一种手持式聚焦剪切波瞬态弹性成像（fTE）装置，该装置配备可更换的凹面活塞，用于产生聚焦剪切波，以增强深部组织的弹性成像效果。该装置由一个3D打印的凹面圆形活塞组成，安装在由机械振动器驱动的相控超声阵列表面。台式装置验证了剪切波速度（SWS）测量与金标准线阵成像的一致性。手持装置在模拟组织的明胶体模中评估了三种活塞几何形状下的测量重复性。超音速剪切波成像（SSI）提供独立参考测量以验证fTE的SWS计算。评估了45 mm深度处的剪切波振幅及SWS测量一致性。台式验证证实，fTE测得的SWS与传统平面活塞TE测量结果的偏差在10%以内。手持装置在所有活塞几何形状下及与SSI对比均表现出无偏的SWS。在45 mm深度处，聚焦活塞产生的剪切波振幅约为非聚焦活塞的2至7倍，具体取决于聚焦增益和明胶硬度。配对F检验证实，使用非聚焦剪切波的SWS测量方差显著大于使用聚焦剪切波（p < 0.0001）。这些结果证明了表面产生聚焦剪切波用于稳健硬度评估的可行性。通过显著增加深部剪切波振幅并利用聚焦剪切波提高测量一致性，该手持式fTE装置解决了传统瞬态弹性成像在深部肝脏或高体重指数患者中的主要局限性。
Abstract
Noninvasive liver stiffness assessment using shear wave elastography is often limited by wave attenuation in deep tissue. We introduce and validate a handheld focused shear wave transient elastography (fTE) device with interchangeable concave pistons to generate focused shear waves for enhanced elastography in deep tissues. The device consists of a 3D-printed concave circular piston fit over the face of a phased ultrasound array driven by a mechanical vibrator. Benchtop setup validated shear wave speed (SWS) measurement against ground-truth linear array imaging. Handheld setup assessed measurement repeatability across three piston geometries in tissue-mimicking gelatin phantoms. Supersonic shear wave imaging (SSI) provided independent reference measurements to validate fTE SWS calculations. Shear wave amplitude at 45 mm depth and SWS measurement consistency were assessed. Benchtop validation confirmed that fTE-measured SWS agreed within 10% of conventional flat piston TE measurements. Handheld setup demonstrated unbiased SWS across all piston geometries and against SSI. At a 45 mm depth, focused pistons produced approximately twofold to sevenfold greater shear wave amplitude than unfocused, depending on focusing gain and gelatin stiffness. Pairwise F-tests confirmed that SWS measurement using unfocused shear waves had significantly larger variance than using focused waves (p < 0.0001). These results demonstrate the feasibility of surface-generated focused shear waves for robust stiffness assessment. By significantly increasing shear wave amplitude at depth and improving measurement consistency with focused shear waves, this handheld fTE device addresses a primary limitation of conventional transient elastography in patients with deep livers or high body mass index.
如何引用
AMA
Yu-Hsuan Chao, John M Cormack, Kang Kim. A Handheld Probe for Focused Shear Wave Transient Elastography.. Annals of biomedical engineering. 2026; doi:10.1007/s10439-026-04316-1.
APA
Yu-Hsuan Chao, John M Cormack, Kang Kim (2026). A Handheld Probe for Focused Shear Wave Transient Elastography.. Annals of biomedical engineering. https://doi.org/10.1007/s10439-026-04316-1
GB/T 7714
Yu-Hsuan Chao, John M Cormack, Kang Kim. A Handheld Probe for Focused Shear Wave Transient Elastography.[J]. Annals of biomedical engineering, 2026 doi:10.1007/s10439-026-04316-1.
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