脉冲射频治疗中风后并发症：从神经调控到功能恢复。

摘要(中文译文)

本综述综合了脉冲射频（PRF）在卒中后并发症康复中的机制、应用及证据缺口，以指导其规范化整合。PRF是一种微创神经调控技术，可在不造成热损伤的情况下调节神经元兴奋性。新出现的证据强调其多靶点效应，包括改善微循环、抑制神经炎症和调节神经营养因子。在临床上，PRF可有效缓解难治性卒中后疼痛，并可能间接改善卒中后抑郁，同时促进运动功能恢复。针对特定神经的影像引导操作显示出良好的安全性。尽管在卒中康复方面结果令人鼓舞，但当前证据主要依赖于小型病例系列和临床前研究。在标准化方案和高质量随机对照试验方面仍存在显著缺口。进一步验证长期疗效和安全性对于确立PRF在卒中后综合管理中的明确作用至关重要。

Abstract

This review synthesizes the mechanisms, applications, and evidence gaps regarding pulsed radiofrequency (PRF) in the rehabilitation of post-stroke complications to guide its standardized integration. PRF, a minimally invasive neuromodulation technique, modulates neuronal excitability without thermal damage. Emerging evidence highlights multi-target effects, including improved microcirculation, suppressed neuroinflammation, and regulated neurotrophic factors. Clinically, PRF effectively alleviates refractory post-stroke pain and may indirectly ameliorate post-stroke depression while facilitating motor recovery. Image-guided procedures targeting specific nerves demonstrate favorable safety profiles. Despite promising outcomes for stroke rehabilitation, current evidence relies primarily on small case series and preclinical studies. Significant gaps remain in standardized protocols and high-quality randomized controlled trials. Further validation of long-term efficacy and safety is essential to establish PRF's definitive role in comprehensive post-stroke management.

如何引用

Current neurology and neuroscience reports 的其他文献

• 以人工智能重新定义脑卒中照护：近期进展。