老年人感官损伤与抑郁发生风险：一项涵盖六个国际队列72，177人的协调纵向分析
Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts.
摘要(中文译文)
将感觉障碍与抑郁联系起来的证据主要来自西方国家。我们利用六个国家的统一数据，量化了单一和双重感觉障碍（DSI）与新发抑郁的纵向关联。我们分析了来自HRS（美国）、ELSA（英国）、SHARE（欧洲）、CHARLS（中国）、KLOSA（韩国）和MHAS（墨西哥）的72,177名老年人（年龄≥50岁）。基线（2010-2015年）无抑郁的参与者被随访2-10年。感觉状态分为无损害、仅视力损害（VI）、仅听力损害（HI）和双重感觉障碍。我们使用多变量Cox模型和个体参与者数据（IPD）荟萃分析来估计合并风险比（HR）。感觉障碍与抑郁风险增加 consistently 相关。双重感觉障碍风险最高（合并HR 1.39，95% CI 1.32-1.46），其次是仅听力损害（HR 1.21，1.16-1.27）和仅视力损害（HR 1.15，1.11-1.20）。西方队列中的关联（英国/美国DSI HR≥1.84）强于亚洲和拉丁美洲人群。亚组分析显示，受过大学教育的个体中DSI相关风险（HR 1.68）高于受教育程度较低者（HR 1.35）。感觉障碍，尤其是双重感觉障碍，在全球范围内与新发抑郁强烈相关，但效应因地缘政治和社会经济背景而异。整合感觉和心理健康筛查对于预防晚年抑郁至关重要。
Abstract
Evidence linking sensory impairment to depression is predominantly Western. We quantified longitudinal associations of single and dual sensory impairment (DSI) with incident depression using harmonized data from six countries. We analyzed 72,177 older adults (aged ≥50) from HRS (USA), ELSA (UK), SHARE (Europe), CHARLS (China), KLOSA (South Korea), and MHAS (Mexico). Participants free of depression at baseline (2010-2015) were followed for 2-10 years. Sensory status was categorized as no impairment, vision impairment only (VI), hearing impairment only (HI), and DSI. We used multivariable Cox models and individual participant data (IPD) meta-analysis to estimate pooled hazard ratios (HRs). Sensory impairment was consistently associated with an increased depression risk. DSI conferred the highest risk (pooled HR 1.39, 95% CI 1.32-1.46), followed by HI (HR 1.21, 1.16-1.27) and VI (HR 1.15, 1.11-1.20). Associations were stronger in Western cohorts (DSI HRs ≥1.84 in UK/USA) than in Asian and Latin American populations. Subgroup analyses showed higher DSI-associated risk among individuals with college education (HR 1.68) compared to those with lower education (HR 1.35). Sensory impairment, particularly DSI, is robustly associated with incident depression globally, though effects vary by geopolitical and socioeconomic context. Integrated sensory and mental health screening is critical for preventing late-life depression.
如何引用
AMA
Lin Guo, Linlin Zhang, Zengying Zhuang, Yanjie Jiang, Linlin Yue. Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts.. Frontiers in public health. 2026; doi:10.3389/fpubh.2026.1834248.
APA
Lin Guo, Linlin Zhang, Zengying Zhuang, Yanjie Jiang, Linlin Yue (2026). Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts.. Frontiers in public health. https://doi.org/10.3389/fpubh.2026.1834248
GB/T 7714
Lin Guo, Linlin Zhang, Zengying Zhuang, Yanjie Jiang, Linlin Yue. Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts.[J]. Frontiers in public health, 2026 doi:10.3389/fpubh.2026.1834248.
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