[从临床获益到机制分析：智三针联合其他疗法干预血管性痴呆的研究进展]
[From clinical benefit to mechanism analysis: research progress on the combined intervention of intelligence three-needling and other therapies in vascular dementia].
摘要(中文译文)
血管性痴呆(vascular dementia, VD)是一种常见的认知功能障碍综合征,目前尚无有效治疗手段。作为金锐教授创立的特色针刺疗法,智三针(一种特定的三穴组合)选取神庭(GV24)与双侧本神(GB13),在改善血管性痴呆患者认知功能方面显示出显著临床疗效。本文从临床与机制两个角度系统综述了智三针治疗血管性痴呆的研究进展:(1)临床方面,智三针通过手针或电针方式,单独应用或联合药物及康复训练,可有效改善患者简易精神状态检查量表与长谷川痴呆量表的评分及日常生活能力。(2)机制方面,智三针发挥多靶点、多通路的神经保护作用,包括降低同型半胱氨酸、β-淀粉样蛋白等神经毒性物质,抑制神经炎症反应,调节突触可塑性相关蛋白,改善脑血流灌注,并通过调控Eph/ephrin信号通路及GABA能系统促进神经元修复与功能恢复。
Abstract
Vascular dementia (VD) is a common cognitive impairment syndrome, for which there is currently no effective treatment. As a distinctive acupuncture therapy founded by Professor Jin Rui, the intelligence three-needling (Zhisanzhen, a specific set of 3 acupuncture points) selects the acupoints Shenting (GV24) and bilateral Benshen (GB13), and has shown significant clinical efficacy in improving cognitive function in patients with vascular dementia. This article systematically reviewed the research progress of intelligence three-needling in treating vascular dementia from both clinical and mechanistic perspectives: (1) Clinically, intelligence three-needling, applied via manual acupuncture or electroacupuncture, either alone or in combination with medication and rehabilitation training, can effectively improve patients' scores on the Mini-Mental State Examination and Hasegawa Dementia Scale, as well as their daily living abilities. (2) Mechanistically, intelligence three-needling exerts multi-target and multi-pathway neuroprotective effects, including reducing neurotoxic substances such as homocysteine and β-amyloid, inhibiting neuroinflammatory responses, modulating synaptic plasticity-related proteins, improving cerebral blood flow perfusion, and promoting neuronal repair and functional recovery by regulating the Eph/ephrin signaling pathway and GABAergic system.
如何引用
AMA
Run-Jin Zhou, Yin-Tong Liang, Zhan-Peng Feng, Wei Liu, Jing-Yi Li, Jun-Xi Yu, et al. [From clinical benefit to mechanism analysis: research progress on the combined intervention of intelligence three-needling and other therapies in vascular dementia].. Zhen ci yan jiu = Acupuncture research. 2026; doi:10.13702/j.1000-0607.20251048.
APA
Run-Jin Zhou, Yin-Tong Liang, Zhan-Peng Feng, Wei Liu, Jing-Yi Li, Jun-Xi Yu, et al (2026). [From clinical benefit to mechanism analysis: research progress on the combined intervention of intelligence three-needling and other therapies in vascular dementia].. Zhen ci yan jiu = Acupuncture research. https://doi.org/10.13702/j.1000-0607.20251048
GB/T 7714
Run-Jin Zhou, Yin-Tong Liang, Zhan-Peng Feng, Wei Liu, Jing-Yi Li, Jun-Xi Yu, et al. [From clinical benefit to mechanism analysis: research progress on the combined intervention of intelligence three-needling and other therapies in vascular dementia].[J]. Zhen ci yan jiu = Acupuncture research, 2026 doi:10.13702/j.1000-0607.20251048.
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