靶向线粒体功能的天然多糖用于大肠癌癌症预防和治疗：机制和纳米递送策略
Natural polysaccharides targeting mitochondrial function for colorectal cancer prevention and treatment: mechanisms and nano-delivery strategies.
摘要(中文译文)
结直肠癌（CRC）是全球范围内发病率和死亡率均较高的消化系统恶性肿瘤。线粒体功能障碍在结直肠癌的发生、进展及化疗耐药中发挥核心作用。近年来，天然多糖因其来源广泛、毒性低、生物相容性好及多靶点活性等特点，在抗结直肠癌研究中受到越来越多的关注。系统综述天然多糖靶向线粒体功能障碍防治结直肠癌的分子机制，并总结纳米递送策略的研究进展。系统检索PubMed、Web of Science、Scopus及SinoMed数据库中2015年1月1日至2026年6月3日发表的文献，共纳入89篇文献进行分析。天然多糖通过调控活性氧稳态、诱导线粒体凋亡与自噬、重塑肿瘤免疫微环境及保护肠道屏障功能等多途径协同发挥抗结直肠癌作用，其生物活性与分子量、单糖组成、糖苷键类型、分支结构及化学修饰密切相关。纳米递送技术可显著提高其靶向效率与治疗活性。在临床研究方面，现有证据主要集中于天然多糖与化疗联合应用及癌症相关症状管理，针对结直肠癌耐药的直接临床证据仍有限。基于天然多糖的线粒体靶向纳米系统为结直肠癌的预防、治疗及逆转化疗耐药提供了有前景的多靶点策略，但现有证据存在结构表征不一致、缺乏直接共定位证据及药代动力学-药效学评价不足等局限性。
Abstract
Colorectal cancer (CRC) is a malignant tumor of the digestive system with high incidence and mortality worldwide. Mitochondrial dysfunction plays a central role in the development, progression, and chemotherapy resistance of CRC. Natural polysaccharides have attracted increasing attention in anti-CRC research in recent years due to their wide sources, low toxicity, good biocompatibility, and multi-target activities. To systematically review the molecular mechanisms by which natural polysaccharides target mitochondrial dysfunction to prevent and treat CRC, and to summarize the research progress of nano-delivery strategies. A systematic search was conducted in PubMed, Web of Science, Scopus, and SinoMed databases for literature published from January 1, 2015 to June 3, 2026. A total of 89 articles were included for analysis. Natural polysaccharides exert anti-CRC effects through synergistic actions of multiple pathways, including regulation of reactive oxygen species homeostasis, induction of mitochondrial apoptosis and autophagy, remodeling of the tumor immune microenvironment, and protection of intestinal barrier function. Their bioactivities are closely related to molecular weight, monosaccharide composition, glycosidic bond type, branching structure, and chemical modification. Nano-delivery technologies can significantly improve their targeting efficiency and therapeutic activity. Regarding clinical studies, current evidence mainly focuses on the combined use of natural polysaccharides with chemotherapy and the management of cancer-related symptoms; direct clinical evidence targeting CRC resistance remains limited. Mitochondria-targeting nano-systems based on natural polysaccharides provide a promising multi-target strategy for CRC prevention, treatment, and reversal of chemotherapy resistance. However, current evidence has limitations, including inconsistent structural characterization, lack of direct co-localization evidence, and insufficient pharmacokinetic-pharmacodynamic evaluations.
如何引用
AMA
Huan Yan, Lianfeng Wang, Jiaxin Gan, Xin Zhou, Yuxin Jiang, Honglian Wang, et al. Natural polysaccharides targeting mitochondrial function for colorectal cancer prevention and treatment: mechanisms and nano-delivery strategies.. Chinese medicine. 2026; doi:10.1186/s13020-026-01463-4.
APA
Huan Yan, Lianfeng Wang, Jiaxin Gan, Xin Zhou, Yuxin Jiang, Honglian Wang, et al (2026). Natural polysaccharides targeting mitochondrial function for colorectal cancer prevention and treatment: mechanisms and nano-delivery strategies.. Chinese medicine. https://doi.org/10.1186/s13020-026-01463-4
GB/T 7714
Huan Yan, Lianfeng Wang, Jiaxin Gan, Xin Zhou, Yuxin Jiang, Honglian Wang, et al. Natural polysaccharides targeting mitochondrial function for colorectal cancer prevention and treatment: mechanisms and nano-delivery strategies.[J]. Chinese medicine, 2026 doi:10.1186/s13020-026-01463-4.
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