产前接触全氟和多氟烷基物质（PFAS）与儿童疫苗诱导免疫的关系
Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.
摘要(中文译文)
血浆全氟和多氟烷基物质（PFAS）与免疫功能异常相关，包括儿童期抗体应答。我们评估了妊娠早期母体血浆PFAS浓度是否与儿童中期MMR（麻疹、腮腺炎、风疹）和DTaP（白喉、破伤风、百日咳）抗体滴度相关。我们测定了纵向Project Viva队列参与者妊娠早期血浆中六种PFAS（EtFOSSA、MeFOSSA、PFHxS、PFNA、PFOA、PFOS）的浓度，该队列于1999—2002年在马萨诸塞州东部招募。我们测定了儿童中期血浆MMR和DTaP抗体滴度。我们根据2007年美国疾病控制中心指南将分析样本限制为完成全程疫苗接种的儿童，并使用协变量校正的分位数g计算和回归分析估计关联（n = 333—416）。抗体滴度采血时的年龄中位数[四分位距（IQR）]为7.7岁（7.4，8.4），儿童最近一次接种MMR或DTaP剂次的时间中位数（IQR）为4.3年（4.1，5.0）。PFAS混合物与较低抗体滴度相关，但麻疹除外，尽管所有关联均未达到统计学显著性。EtFOSSA每增加一个单位（ng/mL）与较高的麻疹抗体滴度相关[β = 0.02，95%置信区间（CI） = 0.01，0.04抗体（Ab）指数]。MeFOSSA每增加1 ng/mL与百日咳抗体滴度降低6.8%（95% CI：-11.9，-1.3）相关。有证据表明婴儿性别对产前PFOS与儿童期百日咳抗体滴度之间的关联存在效应修饰，较高的产前PFOS与女性较低抗体滴度相关，而与男性较高抗体滴度相关，但两种关联均未达到统计学显著性。尽管在我们的队列中产前PFAS混合物与儿童期抗体滴度无显著关联，但我们观察到EtFOSSA与较高麻疹抗体滴度之间以及MeFOSSA与较低百日咳抗体滴度之间的个体关联。总体而言，我们在本队列中发现的妊娠早期血浆PFAS与儿童中期抗体滴度之间关联的证据有限。临床试验编号：不适用。
Abstract
Plasma per- and polyfluoroalkyl substances (PFAS) are associated with immune dysfunction, including childhood antibody response. We evaluated whether first trimester maternal plasma PFAS concentrations are associated with mid-childhood MMR (measles, mumps, rubella) and DTaP (diphtheria, tetanus, pertussis) antibody titers. We measured six PFAS (EtFOSSA, MeFOSSA, PFHxS, PFNA, PFOA, PFOS) in first trimester plasma from participants in the longitudinal Project Viva cohort, recruited 1999-2002 in eastern Massachusetts. We measured mid-childhood plasma MMR and DTaP antibody titers. We restricted the analytical sample to children fully vaccinated, according to 2007 United States Center for Disease Control guidelines and used covariate-adjusted quantile g-computation and regression analyses to estimate associations (n = 333-416). Median [interquartile range (IQR)] age at antibody titer blood draw was 7.7 years (7.4, 8.4), and children received their most recent MMR or DTaP dose at median (IQR) 4.3 years (4.1, 5.0). The PFAS mixture was associated with lower antibody titers, except for measles, although none of the associations reached statistical significance. A one unit (ng/mL) increase in EtFOSSA was associated with higher measles antibody titers [β = 0.02, 95% confidence interval (CI) = 0.01, 0.04 antibody (Ab) index]. A one ng/mL increase in MeFOSSA was associated with - 6.8% (95% CI: -11.9, -1.3) lower pertussis antibody titers. There was evidence of effect modification by infant sex for prenatal PFOS and childhood pertussis antibody titers, with higher prenatal PFOS associated with lower antibody titers in females and higher in males, although neither association reached statistical significance. While the prenatal PFAS mixture was not significantly associated with childhood antibody titers in our cohort, we observed individual associations between EtFOSSA and higher measles antibody titers and MeFOSSA and lower pertussis antibody titers. Overall, we found limited evidence of associations between first trimester plasma PFAS and mid-childhood antibody titers in our cohort. Clinical trial number: not applicable.
如何引用
AMA
Anna Smith, Pi-I D Lin, Sheryl L Rifas-Shiman, Diane R Gold, Marie-France Hivert, Emily Oken, et al. Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.. Environmental health : a global access science source. 2026; doi:10.1186/s12940-026-01322-7.
APA
Anna Smith, Pi-I D Lin, Sheryl L Rifas-Shiman, Diane R Gold, Marie-France Hivert, Emily Oken, et al (2026). Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.. Environmental health : a global access science source. https://doi.org/10.1186/s12940-026-01322-7
GB/T 7714
Anna Smith, Pi-I D Lin, Sheryl L Rifas-Shiman, Diane R Gold, Marie-France Hivert, Emily Oken, et al. Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.[J]. Environmental health : a global access science source, 2026 doi:10.1186/s12940-026-01322-7.
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