癌症化疗所致恶心和呕吐的多学科管理方法
A Multi-Disciplinary Approach to the Management of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer.
摘要(中文译文)
化疗是乳腺癌综合治疗的基石。然而，其非特异性细胞毒性作用常累及胃肠道，导致一系列消化道不良反应，包括化疗所致恶心呕吐（CINV）、厌食、腹泻和便秘。这些症状不仅损害患者的生活质量，还可能影响治疗依从性。严重时甚至需要减量或中断治疗。本综述系统梳理了乳腺癌化疗相关胃肠道不良反应的流行病学、病理生理学及分类，重点聚焦CINV的管理策略，包括药物预防、个体化风险评估、非药物干预及标准化评估工具的应用。基于现有证据，我们探讨了从经验性护理模式向预测性护理模式的转变，并强调了患者教育、心理支持及家庭参与的重要性，同时着重指出了乳腺癌患者的特殊考量。本综述为乳腺癌CINV的临床护理提供了系统、循证的参考，以优化胃肠道症状管理，改善患者的治疗结局与生活质量。
Abstract
Chemotherapy is a cornerstone of comprehensive breast cancer treatment. However, its non-specific cytotoxic effects frequently involve the gastrointestinal tract, leading to a spectrum of digestive adverse reactions, including chemotherapy-induced nausea and vomiting (CINV), anorexia, diarrhea, and constipation. These symptoms not only compromise patients' quality of life but may also impair treatment adherence. In severe cases, they can necessitate dose reduction or treatment discontinuation. This review systematically examines the epidemiology, pathophysiology, and classification of gastrointestinal adverse reactions associated with breast cancer chemotherapy, with a focus on CINV management strategies. These strategies include pharmacological prophylaxis, individualized risk assessment, non-pharmacological interventions, and the use of standardized assessment tools. Based on the available evidence, we discuss the transition from an experience-based nursing model to a predictive one. We also emphasize the importance of patient education, psychological support, and family involvement, and highlight specific considerations for breast cancer patients. This review provides a systematic, evidence‑based reference for the clinical care of CINV in breast cancer to optimize gastrointestinal symptom management and improve treatment outcomes and quality of life for these patients.
如何引用
AMA
Fang Chen, Kai Cao, Xiaoyan Zhao, Liping Xia, Meng Liu, Yifan Jiang. A Multi-Disciplinary Approach to the Management of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer.. Therapeutics and clinical risk management. 2026; doi:10.2147/TCRM.S620981.
APA
Fang Chen, Kai Cao, Xiaoyan Zhao, Liping Xia, Meng Liu, Yifan Jiang (2026). A Multi-Disciplinary Approach to the Management of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer.. Therapeutics and clinical risk management. https://doi.org/10.2147/TCRM.S620981
GB/T 7714
Fang Chen, Kai Cao, Xiaoyan Zhao, Liping Xia, Meng Liu, Yifan Jiang. A Multi-Disciplinary Approach to the Management of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer.[J]. Therapeutics and clinical risk management, 2026 doi:10.2147/TCRM.S620981.
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