不伴有严重高血压的非典型子痫——眼动脉多普勒和sFlt-1/PlGF比值的作用：病例报告

摘要(中文译文)

子痫仍然是与大量孕产妇和围产期发病率和死亡率相关的最严重的产科急诊之一。虽然传统上被认为是先兆子痫的高血压并发症，但可能会出现没有持续高血压或严重临床特征的非典型症状，这使风险预测和及时干预变得复杂。我们报告了一例21岁女性非典型子痫病例，她被诊断为先兆子痫，但没有严重特征。尽管血压值基本正常，实验室检查结果最初稳定，但sFlt-1/PlGF比值和子宫和眼动脉的多普勒评估显示出明显的异常。患者随后出现全身强直阵挛发作，需要紧急产科干预。该病例强调了传统诊断标准在识别有突然神经恶化风险的患者方面的局限性，并强调了血管生成生物标志物和靶向多普勒评估在完善先兆子痫女性风险分层方面的潜在价值。

Abstract

Eclampsia remains one of the most severe obstetric emergencies associated with substantial maternal and perinatal morbidity and mortality. Although classically regarded as a hypertensive complication of pre-eclampsia, atypical presentations without sustained hypertension or severe clinical features may occur, complicating risk prediction and timely intervention. We report a case of atypical eclampsia in a 21-year-old woman hospitalized with a diagnosis of pre-eclampsia without severe features. Despite predominantly normal blood pressure values and initially stable laboratory findings, the sFlt-1/PlGF ratio and Doppler assessment of the uterine and ophthalmic arteries revealed significant abnormalities. The patient subsequently developed generalized tonic-clonic seizures, requiring urgent obstetric intervention. This case underscores the limitations of conventional diagnostic criteria in identifying patients at risk for sudden neurological deterioration and highlights the potential value of angiogenic biomarkers and targeted Doppler evaluation in refining risk stratification among women with pre-eclampsia.

如何引用