心血管-肾脏代谢综合征1-3期患者中与心血管疾病发病率相关的风险因素目标达成情况：一项全国性队列研究的结果
Risk factor target achievement in relation to incident cardiovascular disease among individuals with cardiovascular-kidney-metabolic syndrome stage 1-3: results from a nationwide cohort study.
摘要(中文译文)
在心血管-肾脏-代谢（CKM）综合征1-3期人群中，风险因素目标达成情况与新发心血管疾病（CVD）风险之间的关联尚不明确。我们在中国健康与养老追踪调查（CHARLS）队列中研究了这一关联。本研究纳入6,501名CKM 1-3期个体。关注的暴露因素为基线时达成的风险因素目标数量，包括收缩压（SBP）< 130 mm Hg、空腹血糖 < 6.1 mmol/L、低密度脂蛋白胆固醇（LDL-C）< 2.6 mmol/L以及中高强度体力活动。采用Cox比例风险回归模型分析达成目标数量与CVD风险之间的关联。在中位随访9.0年期间，共记录到1,221例新发CVD事件和539例卒中事件。与基线时未达成任何风险因素目标的参与者相比，达成全部四项目标的参与者CVD风险（校正风险比[aHR]：0.40，95% CI：0.26-0.62）和卒中风险（aHR：0.39，95% CI：0.20-0.75）均显著降低。分层分析表明，达成目标数量与CVD风险之间的负向关联在60岁以下参与者中强于60岁及以上参与者（交互作用P < 0.05）。在CKM 1-3期个体中，基线时达成的风险因素目标数量越多，随后发生CVD的风险越低。
Abstract
The association between risk factor target achievement and the risk of incident cardiovascular disease (CVD) among individuals with cardiovascular-kidney-metabolic (CKM) syndrome stages 1-3 remains unclear. We investigated this association within the China Health and Retirement Longitudinal Study (CHARLS) cohort. This study included 6,501 individuals with CKM stages 1-3. The exposure of interest was the number of risk factor targets achieved at baseline, including systolic blood pressure (SBP) < 130 mm Hg, fasting blood glucose < 6.1 mmol/L, low-density lipoprotein cholesterol (LDL-C) < 2.6 mmol/L, and moderate-to-vigorous physical activity. Cox proportional hazards regression models were used to analyse the association between the number of targets achieved and the risk of CVD. During a median follow-up of 9.0 years, 1,221 incident CVD events and 539 stroke events were documented. Compared with participants achieving no risk factor targets at baseline, those achieving all four targets had a significantly lower risk of both CVD (adjusted hazard ratio [aHR]: 0.40, 95% CI: 0.26-0.62) and stroke (aHR: 0.39, 95% CI: 0.20-0.75). Stratified analyses indicated that the inverse association between the number of achieved targets and CVD risk was stronger among participants younger than 60 years than among those aged 60 years or older (P for interaction < 0.05). A greater number of risk factor targets achieved at baseline was associated with a lower subsequent risk of CVD in individuals with CKM stages 1-3.
如何引用
AMA
Bin-Bin He, Guo-Yan Wu. Risk factor target achievement in relation to incident cardiovascular disease among individuals with cardiovascular-kidney-metabolic syndrome stage 1-3: results from a nationwide cohort study.. BMC cardiovascular disorders. 2026; doi:10.1186/s12872-026-06162-4.
APA
Bin-Bin He, Guo-Yan Wu (2026). Risk factor target achievement in relation to incident cardiovascular disease among individuals with cardiovascular-kidney-metabolic syndrome stage 1-3: results from a nationwide cohort study.. BMC cardiovascular disorders. https://doi.org/10.1186/s12872-026-06162-4
GB/T 7714
Bin-Bin He, Guo-Yan Wu. Risk factor target achievement in relation to incident cardiovascular disease among individuals with cardiovascular-kidney-metabolic syndrome stage 1-3: results from a nationwide cohort study.[J]. BMC cardiovascular disorders, 2026 doi:10.1186/s12872-026-06162-4.
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