【草原田鼠配对社交性的神经生物学】
[Neurobiology of pair-bonded sociality in prairie voles].
摘要(中文译文)
利用小鼠和大鼠开展的研究推进了我们对社会行为神经机制的理解。具体而言，背侧海马CA2区、腹侧海马CA1区及伏隔核已被确定为社会识别（social recognition）的关键脑区，而内侧视前区则是亲代行为（parental behavior）的核心枢纽。然而，这些多配偶制物种并不适合研究“配对联结”（pair bonding）——即对特定配偶持续且选择性的偏好。为解决这一问题，本综述聚焦于一夫一妻制的草原田鼠（prairie voles）。配对联结的形成需要神经调质——包括加压素（vasopressin）、催产素（oxytocin）和多巴胺（dopamine）——在伏隔核和腹侧苍白球等奖赏区域内协同作用，将配偶特异性的感觉线索与奖赏价值相关联。近期研究进一步揭示，内侧前额叶皮层和伏隔核中特定的神经动力学动态调控配对联结的形成，且腹侧海马CA1神经元表现出配偶特异性的活动。综合而言，理解社会性的生物学原理需要将小鼠中阐明的社会识别机制与草原田鼠中展示的 valuation 机制相整合。阐明大脑如何将特定个体与他人区分开来并将其编码为“特殊”，仍是社会神经生物学未来面临的关键挑战。
Abstract
Our understanding of the neural mechanisms underlying social behavior has been advanced by research using mice and rats. Specifically, the dorsal hippocampal CA2 area, ventral hippocampal CA1 area, and nucleus accumbens have been identified as critical for social recognition, while the medial preoptic area serves as a central hub for parental behavior. However, these polygamous species are unsuitable for studying "pair bonding"-an enduring, selective preference for a specific mate. To address this, this review focuses on monogamous prairie voles. Pair bond formation requires neuromodulators-including vasopressin, oxytocin, and dopamine-acting synergistically within reward regions such as the nucleus accumbens and ventral pallidum to associate partner-specific sensory cues with reward value. Recent studies further reveal that specific neural dynamics in the medial prefrontal cortex and nucleus accumbens dynamically regulate bond formation, and that the ventral hippocampal CA1 neurons exhibit partner-specific activity. Comprehensively, understanding the biological principles of sociality requires integrating the social identification mechanisms elucidated in mice with the valuation mechanisms demonstrated in prairie voles. Elucidating how the brain distinguishes the specific individual from the others and encodes him/her as "special" remains a key challenge for the future of social neurobiology.
如何引用
AMA
Mikuru Kudara, Haruka Suzuki, Yuji Ikegaya, Nobuyoshi Matsumoto. [Neurobiology of pair-bonded sociality in prairie voles].. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2026; doi:10.1254/fpj.26033.
APA
Mikuru Kudara, Haruka Suzuki, Yuji Ikegaya, Nobuyoshi Matsumoto (2026). [Neurobiology of pair-bonded sociality in prairie voles].. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. https://doi.org/10.1254/fpj.26033
GB/T 7714
Mikuru Kudara, Haruka Suzuki, Yuji Ikegaya, Nobuyoshi Matsumoto. [Neurobiology of pair-bonded sociality in prairie voles].[J]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2026 doi:10.1254/fpj.26033.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出