巴氯芬在临床实践中的误用：一例管理策略病例报告
Baclofen Misuse in Clinical Practice: A Case Report on Management Strategies.
摘要(中文译文)
巴氯芬（baclofen）是一种GABA_B受体激动剂，其与滥用及严重戒断症状的关联日益受到关注，这些症状包括急性神经精神表现。我们报告一例26岁男性，表现为严重物质使用障碍和反复抑郁发作，伴有严重失眠、自杀意念和视幻觉。他长期服用高剂量巴氯芬（200 mg/天）达2至3年，且仍不时使用可卡因和阿片类药物。患者无急性中毒表现，实验室检查和心电图均正常。考虑其正处于巴氯芬戒断状态，遂给予劳拉西泮2 mg，并在2周内缓慢减量，最终临床状况稳定。本病例强调巴氯芬戒断是精神状况恶化的一种潜在致命因素，并提示对合并精神障碍和物质使用的患者尤其需要及时识别、细致观察和个体化干预。
Abstract
Baclofen, a GABA_B receptor agonist, is increasingly linked to misuse and severe withdrawal symptoms, including acute neuropsychiatric manifestations. We present a 26-year-old male exhibiting severe substance use disorder and recurrent depressive episodes, accompanied by profound insomnia, suicidal ideation, and visual hallucinations. He had been taking baclofen in high doses (200 mg/day) for 2-3 years, and he was still using cocaine and opioids from time to time. There was no acute intoxication, and the lab tests and electrocardiography were normal. It was thought that he was going through baclofen withdrawal, so he was given lorazepam 2 mg, which was slowly reduced over 2 weeks, leading to clinical stabilization. This case emphasizes baclofen withdrawal as a potentially fatal factor in psychiatric decline and underscores the necessity for prompt identification, meticulous observation, and tailored intervention particularly in patients with psychiatric disorders and comorbid substance use.
如何引用
AMA
Mostafa Yousef, Mohamed Elsayed, Ahmed Hosney Nada, Olivier Uwishema. Baclofen Misuse in Clinical Practice: A Case Report on Management Strategies.. Clinical case reports. 2026; doi:10.1002/ccr3.73067.
APA
Mostafa Yousef, Mohamed Elsayed, Ahmed Hosney Nada, Olivier Uwishema (2026). Baclofen Misuse in Clinical Practice: A Case Report on Management Strategies.. Clinical case reports. https://doi.org/10.1002/ccr3.73067
GB/T 7714
Mostafa Yousef, Mohamed Elsayed, Ahmed Hosney Nada, Olivier Uwishema. Baclofen Misuse in Clinical Practice: A Case Report on Management Strategies.[J]. Clinical case reports, 2026 doi:10.1002/ccr3.73067.
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