成人胆道和胰腺癌（BTPC）：胆道微生物群在癌症中的作用及治疗策略——范围综述
Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies-A Scoping Review.
摘要(中文译文)
胆道和胰腺管道越来越被认为是一个微生物生态系统，而非无菌环境。菌群失调可促进炎症、胆汁酸改变和癌变，且特定的微生物群谱与从良性病变向恶性病变的进展相关。包括肠-肝轴紊乱和胆道支架置入在内的临床因素可能进一步加剧微生物失衡。本研究的目的是综合现有证据，并确定关于胆道微生物群在胰胆管癌变中作用及其对诊断、预后和治疗意义方面的知识空白。本范围综述按照PRISMA-ScR指南进行。依据PICo框架，对PubMed、Web of Science和Scopus中2015年1月至2025年12月发表的研究进行了系统检索。纳入的研究主要描述了微生物群组成的变化，以识别与胰胆疾病相关的微生物生物标志物。预测性生物信息学分析提示，菌群失调可能通过代谢和炎症途径促进癌变。机器学习方法识别出对癌前病变具有潜在诊断价值的基于微生物群的特征，尽管区分能力仍然有限。胆道菌群失调还与胆道支架置入、化学预防、术后并发症以及化疗或手术反应相关的结果有关。将微生物群谱分析与预测性生物信息学和机器学习相结合，可能有助于加深对胰胆管癌变的理解。识别微生物和功能性生物标志物可能实现个性化诊断和治疗策略，最终改善患者预后。
Abstract
The biliary and pancreatic tract is increasingly recognized as a microbial ecosystem rather than a sterile environment. Dysbiosis contributes to inflammation, bile acid alterations, and carcinogenesis, with distinct microbiota profiles linked to progression from benign to malignant conditions. Clinical factors, including gut-liver axis disruption and biliary stenting, may further exacerbate microbial imbalance. The objective of this study is to synthesize current evidence and identify knowledge gaps on the role of biliary microbiota in pancreaticobiliary carcinogenesis and its implications for diagnosis, prognosis, and therapy. This scoping review was conducted following PRISMA-ScR guidelines. A systematic search of PubMed, Web of Science, and Scopus was performed for studies published between January 2015 and December 2025, guided by the PICo framework. Included studies primarily characterized changes in microbiota composition to identify microbial biomarkers associated with pancreaticobiliary diseases. Predictive bioinformatics analyses suggest that dysbiosis may promote carcinogenesis through metabolic and inflammatory pathways. Machine learning approaches identified microbiota-based signatures with potential diagnostic value for precancerous lesions, although discrimination remains limited. Biliary dysbiosis was also associated with outcomes related to biliary stenting, chemoprophylaxis, postoperative complications, and responses to chemotherapy or surgery. Integration of microbiota profiling with predictive bioinformatics and machine learning may improve understanding of pancreaticobiliary carcinogenesis. Identifying microbial and functional biomarkers could enable personalized diagnostic and therapeutic strategies, ultimately improving patient outcomes.
如何引用
AMA
Paola Di Carlo, Nicola Serra, Aducio Thiesen, Vito Rodolico, Antonio Cascio, Teresa Maria Assunta Fasciana, et al. Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies-A Scoping Review.. Cancers. 2026; doi:10.3390/cancers18121875.
APA
Paola Di Carlo, Nicola Serra, Aducio Thiesen, Vito Rodolico, Antonio Cascio, Teresa Maria Assunta Fasciana, et al (2026). Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies-A Scoping Review.. Cancers. https://doi.org/10.3390/cancers18121875
GB/T 7714
Paola Di Carlo, Nicola Serra, Aducio Thiesen, Vito Rodolico, Antonio Cascio, Teresa Maria Assunta Fasciana, et al. Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies-A Scoping Review.[J]. Cancers, 2026 doi:10.3390/cancers18121875.
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