增强酿酒酵母单细胞蛋白生产的代谢与合成生物学策略

摘要(中文译文)

单细胞蛋白（SCP）以其高生产效率、灵活的底物利用能力和优异的营养价值，在饲料和食品领域具有广阔的应用前景。随着合成生物学和代谢工程的发展，单细胞蛋白有望成为主流蛋白质来源，为全球粮食安全和碳中和目标提供关键解决方案。本文以酿酒酵母（Saccharomyces cerevisiae）作为单细胞蛋白底盘，综述了近期旨在提高细胞蛋白含量和细胞生物量的代谢与合成生物学策略，从而提升其可持续大规模蛋白质生产的潜力。

Abstract

Single cell protein (SCP), distinguished by its high production efficiency, flexible substrate utilization, and excellent nutritional value, has broad application prospects in both feed and food sectors. With the advancement of synthetic biology and metabolic engineering, SCP is poised to become a mainstream protein source, providing key solutions for global food security and carbon neutrality goals. This review focuses on Saccharomyces cerevisiae as an SCP chassis and summarizes recent metabolic and synthetic biology strategies aimed at enhancing cellular protein content and cell biomass, thereby improving its potential for sustainable large-scale protein production.

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