膳食类黄酮摄入量与神经退行性疾病风险之间的关联：一项横断面研究
The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross-Sectional Study.
摘要(中文译文)
神经退行性疾病（NDs）的发病率，主要是阿尔茨海默病和帕金森病，一直在稳步上升，构成了重大的全球公共卫生挑战。本研究旨在评估膳食类黄酮摄入量与神经退行性疾病风险之间的关联。分析了来自国家健康与营养调查（NHANES）中13，573名参与者的数据。采用加权逻辑回归、受试者工作特征（ROC）曲线分析、加权限制性立方样条、亚组分析和敏感性分析来评估这些关联。总体而言，在调整人口统计学、社会经济、生活方式和临床协变量后，较高的总类黄酮摄入量与较低的神经退行性疾病发生几率相关（Q4 vs. Q1：OR = 0.52，95% CI：0.31-0.90）。在类黄酮亚类中，黄酮（Q4 vs. Q1：OR = 0.49，95% CI：0.30-0.79）和黄酮醇（Q4 vs. Q1：OR = 0.53，95% CI：0.33-0.86）显示出最强的负相关。此外，限制性立方样条分析显示了显著的非线性关系，在总类黄酮摄入量约432 mg/天、黄酮约1.7 mg/天和黄酮醇约29 mg/天时，观察到神经退行性疾病的发生几率最低。这些发现表明，适量摄入类黄酮，特别是黄酮和黄酮醇，可能有助于解释观察到的类黄酮摄入量与神经退行性疾病之间的负相关。
Abstract
The incidence of neurodegenerative diseases (NDs), primarily Alzheimer's disease and Parkinson's disease, has been steadily increasing, constituting a significant global public health challenge. This study aims to evaluate the associations between dietary flavonoid intake and the risk of NDs. Data from 13,573 participants in the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weighted logistic regression, receiver operating characteristic (ROC) curve analysis, weighted restricted cubic splines, subgroup analysis, and sensitivity analysis were employed to assess the associations. Overall, higher total flavonoid intake was associated with lower odds of NDs after adjustment for demographic, socioeconomic, lifestyle, and clinical covariates (Q4 vs. Q1: OR = 0.52, 95% CI: 0.31-0.90). Among flavonoid subclasses, flavones (Q4 vs. Q1: OR = 0.49, 95% CI: 0.30-0.79) and flavonols (Q4 vs. Q1: OR = 0.53, 95% CI: 0.33-0.86) showed the strongest inverse associations. In addition, restricted cubic spline analyses demonstrated significant non-linear relationships, with the lowest odds of NDs observed at intake levels of approximately 432 mg/day for total flavonoids, 1.7 mg/day for flavones, and 29 mg/day for flavonols. These findings suggest that moderate intake of flavonoids, particularly flavones and flavonols, may contribute to the observed inverse association between flavonoid intake and NDs.
如何引用
AMA
Chenzhong Zong, Yang Dong, Xue Yu, Yu He, Xiaoqing Zhang, Kuo Gao. The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross-Sectional Study.. Chemical biology & drug design. 2026; doi:10.1111/cbdd.70350.
APA
Chenzhong Zong, Yang Dong, Xue Yu, Yu He, Xiaoqing Zhang, Kuo Gao (2026). The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross-Sectional Study.. Chemical biology & drug design. https://doi.org/10.1111/cbdd.70350
GB/T 7714
Chenzhong Zong, Yang Dong, Xue Yu, Yu He, Xiaoqing Zhang, Kuo Gao. The Associations Between Dietary Flavonoid Intake and Neurodegenerative Diseases Risk: A Cross-Sectional Study.[J]. Chemical biology & drug design, 2026 doi:10.1111/cbdd.70350.
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