IL-17靶向干预在组织损伤修复中的临床价值：从双向机制到治疗策略
Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies.
摘要(中文译文)
IL-17是一种多效性细胞因子，通过IL-17受体（IL-17R）激活下游信号通路，影响炎症介质、生长因子和基质金属蛋白酶的表达与调控，从而调节多种生物学过程。近年研究表明，IL-17在组织修复过程中呈现动态的双相效应：在急性期，它通过促进上皮再生、血管生成以及招募修复性免疫细胞来加速组织修复；而在慢性期，过度激活则导致失控性炎症和纤维化进展。这种“双刃剑”效应在皮肤、肺和肠道等不同组织中表现出显著的异质性。尽管IL-17的双重作用已被广泛认可，该领域仍缺乏一个整体性视角来系统阐释这种双重性在不同组织环境中是如何被调控的。本综述概述了IL-17功能二分性的最新研究进展，并指出细胞来源、损伤时相和局部微环境是关键的调控决定因素。我们旨在阐明IL-17在何种情况下以及为何促进组织修复而非加剧纤维化，并讨论这些见解对制定针对不同临床场景的靶向治疗策略的意义。
Abstract
IL-17, a pleiotropic cytokine, activates downstream signaling pathways through the IL-17 receptor (IL-17R), influencing the expression and regulation of inflammatory mediators, growth factors, and matrix metalloproteinases, thereby modulating various biological processes. Recent studies have shown that IL-17 exhibits dynamic biphasic effects during tissue repair: in the acute phase, it accelerates tissue repair by promoting epithelial regeneration, angiogenesis, and the recruitment of reparative immune cells, whereas in the chronic phase, excessive activation leads to uncontrolled inflammation and fibrosis progression. This "double-edged sword" effect shows significant heterogeneity across different tissues, including the skin, lungs, and intestines. Despite the widely recognized dual roles of IL-17, the field still lacks a holistic perspective that systematically explains how this duality is regulated across different tissue environments. This review outlines recent advances in IL-17's functional dichotomy and identifies cellular origin, injury phase, and local microenvironment as critical regulatory determinants. We aim to elucidate under what circumstances and why IL-17 promotes tissue repair rather than exacerbates fibrosis, and discuss the implications of these insights for developing therapeutic strategies tailored to distinct clinical scenarios.
如何引用
AMA
Wenyu An, Xinyi Ma, Runxue Guan, Yufen Zhao, Nina Yang, Liang Jin, et al. Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1773504.
APA
Wenyu An, Xinyi Ma, Runxue Guan, Yufen Zhao, Nina Yang, Liang Jin, et al (2026). Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1773504
GB/T 7714
Wenyu An, Xinyi Ma, Runxue Guan, Yufen Zhao, Nina Yang, Liang Jin, et al. Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1773504.
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