白球外观是异时性多发性胃癌的内镜预测因素
White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers.
摘要(中文译文)
白色球状外观（WGA）是在窄带成像放大内镜下观察到的一种小的白色球状病变。然而，WGA与异时性胃癌之间的关联尚不明确。本研究纳入了2012年1月至2018年12月期间在本机构因首发单发胃癌接受内镜黏膜下剥离术（ESD）且术后至少接受过一次内镜随访的患者。WGA阳性胃癌定义为存在WGA，异时性胃癌定义为ESD后≥1年在不同部位出现的新发癌。主要终点是比较WGA阳性与WGA阴性胃癌患者异时性胃癌的发生率。采用以下变量进行单因素和多因素分析：WGA状态、性别、年龄和重度萎缩。共纳入160例WGA阳性胃癌和284例WGA阴性胃癌病例。WGA阳性组的异时性胃癌发生率显著更高（< 0.01）。单因素分析确定幽门螺杆菌感染（= 0.049）、WGA阳性（< 0.01）和较长的观察期（< 0.01）是与异时性胃癌显著相关的因素。在多因素分析中，仅WGA阳性是显著的独立危险因素（< 0.01）。WGA可能是异时性胃癌的预测标志物。对于WGA阳性胃癌病例，内镜随访时应高度关注异时性病变的风险。
Abstract
White globe appearance (WGA) is a small white lesion with a globular shape identified during magnifying endoscopy with narrow-band imaging. However, the association between WGA and metachronous gastric cancer remains unclear. This study involved patients who underwent endoscopic submucosal dissection (ESD) for first-episode single gastric cancer at our institution between January 2012 and December 2018 and who had at least one endoscopic follow-up after resection. WGA-positive gastric cancer was defined by the presence of WGA, and metachronous gastric cancer was defined as new cancer arising at a different site ≥1 year after ESD. The primary endpoint was a comparison of the incidence of metachronous gastric cancers in patients with WGA-positive versus WGA-negative gastric cancer. Univariate and multivariate analyses were conducted using the following variables: WGA status, sex, age, and severe atrophy. In total, 160 WGA-positive and 284 WGA-negative gastric cancer cases were included. Metachronous gastric cancers were significantly more frequent in the WGA-positive group ( < 0.01). Univariate analysis identified infection ( = 0.049), WGA positivity ( < 0.01), and a longer observation period ( < 0.01) as factors significantly associated with metachronous gastric cancers. In the multivariate analysis, only WGA positivity was a significant independent risk factor ( < 0.01). WGA may be a predictive marker for metachronous gastric cancers. In cases of WGA-positive gastric cancer, endoscopic follow-up should be conducted with heightened attention to the risk of metachronous lesions.
如何引用
AMA
Manami Utsunomiya, Hiroyoshi Nakanishi, Naohiro Yoshida, Saori Miyajima, Azusa Kawasaki, Shigenori Wakita, et al. White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers.. DEN open. 2027; doi:10.1002/deo2.70364.
APA
Manami Utsunomiya, Hiroyoshi Nakanishi, Naohiro Yoshida, Saori Miyajima, Azusa Kawasaki, Shigenori Wakita, et al (2027). White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers.. DEN open. https://doi.org/10.1002/deo2.70364
GB/T 7714
Manami Utsunomiya, Hiroyoshi Nakanishi, Naohiro Yoshida, Saori Miyajima, Azusa Kawasaki, Shigenori Wakita, et al. White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers.[J]. DEN open, 2027 doi:10.1002/deo2.70364.
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