用于非小细胞肺癌中结节分期的EBUS-TBNA样品的分子分析
Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.
摘要(中文译文)
自EGFR突变被发现以来，过去二十年中治疗策略已取得重大进展。因此，推荐在晚期NSCLC诊断时进行致癌驱动基因突变的分子检测。此外，淋巴结样本的分子分析已成为提高NSCLC淋巴结分期准确性的一种有前景的工具。该方法可能提高计划行根治性手术切除的早期疾病的分期精确性，从而优化辅助治疗决策并支持手术时实现完全切除。在本综述中，我们探讨了通过支气管内超声引导经支气管针吸活检（EBUS-TBNA）或EBUS引导冷冻活检所获样本中致癌驱动基因突变分子检测的重要性和现状，及其在提高NSCLC淋巴结分期准确性中的作用。
Abstract
Since the discovery of EGFR mutations, treatment strategies have undergone major advances over the past two decades. Accordingly, molecular testing for oncogenic driver mutations is recommended at the time of diagnosis of advanced NSCLC. In addition, molecular analysis of lymph node samples has emerged as a promising tool for improving the accuracy of nodal staging in NSCLC. This approach may enhance the precision of staging in early-stage disease planned for curative surgical resection, thereby optimizing adjuvant treatment decisions and supporting complete resection at the time of surgery. In this review, we examine the importance and current status of molecular testing for oncogenic driver mutations in samples obtained via endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) or EBUS-guided cryobiopsy, and its role in improving the accuracy of nodal staging in NSCLC.
如何引用
AMA
Ahmed Ehab, Naoufal Benabdallah, Kaid Darwiche. Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.. Cancers. 2026; doi:10.3390/cancers18111797.
APA
Ahmed Ehab, Naoufal Benabdallah, Kaid Darwiche (2026). Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.. Cancers. https://doi.org/10.3390/cancers18111797
GB/T 7714
Ahmed Ehab, Naoufal Benabdallah, Kaid Darwiche. Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.[J]. Cancers, 2026 doi:10.3390/cancers18111797.
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