二极管激光治疗复发性阿弗他口炎和口腔扁平苔藓的疗效：一项系统综述

摘要(中文译文)

评估光生物调节疗法治疗口腔扁平苔藓（OLP）和复发性阿弗他口炎（RAS）的有效性，包括其疗效结局以及患者对安全性的满意度。通过检索PubMed Central、PubMed、Cochrane、CrossRef、Google Scholar和Embase等电子数据库进行了一项系统综述。使用医学主题词（MeSH）以及以下关键词的多种组合，对截至2025年6月发表的文献进行了审查：口腔扁平苔藓、复发性阿弗他口炎、光生物调节疗法和常规药物治疗。我们考虑了两种不同的结局指标，如疼痛和病变大小。由于数据存在异质性，我们未进行任何统计分析。最初筛选出560篇文献用于本综述，在分析全部文献后，仅有12篇符合纳入和排除标准。在所有这些研究中，激光波长、输出功率和照射时间的变化范围分别为630-980nm、20-30mW和10秒至15分钟。对照组使用的局部药物为氨来呫诺、曲安奈德、granofurin和socosenyl。我们的研究结果表明，与局部药物治疗组相比，光生物调节激光组在减轻RAS和OLP的疼痛及缩小病变大小方面更为有效。我们可以得出结论：与其他局部药物治疗相比，光生物调节疗法在治疗RAS和OLP方面更优，具有更好的愈合效果、更高的患者满意度和更低的复发率。

Abstract

To assess the effectiveness of photobiomodulation therapy for managing oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS), including their outcomes and patient satisfaction with the safety profile. A systematic review was conducted by searching electronic databases like PubMed Central, PubMed, Cochrane, CrossRef, Google Scholar, and Embase. Articles published until June 2025 were reviewed using MeSH (Medical Subject Heading) and various combinations of the keywords: oral lichen planus, Recurrent Aphthous Stomatitis, photobiomodulation therapy, and conventional drug therapy. We considered two different outcomes, such as pain and the size of the lesion. Due to the heterogeneity of the data, we did not conduct any statistical analysis. Initially, 560 publications were selected for this review article, and after analyzing all these, only 12 articles fulfilled the inclusion and exclusion criteria. In all those studies, the laser wavelength, power output, and duration of irradiation changed between 630-980 m, 20-30 mW, and 10 sec-15 min have been described. Topical medications used in the comparative group were amlexanox, triamcinolone acetonide, granofurin, and socosenyl. Our findings showed that the photobiomodulation laser group is more effective for decreasing the pain and lesion size of RAS and OLP in comparison with the topical medication group. We can conclude that photobiomodulation therapy was better for treating RAS and OLP with greater healing, patient satisfaction, and lower recurrence rate in comparison with other topical drug therapies.

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