乳酰化在年龄相关疾病中的作用：分子视角
The role of lactylation in age-related diseases: a molecular perspective.
摘要(中文译文)
乳酸化修饰（Kla）是一种新型的翻译后蛋白质修饰调控机制，由糖酵解产生的乳酸与赖氨酸残基共价偶联而实现。乳酸化修饰主要包括组蛋白乳酸化修饰和非组蛋白乳酸化修饰。乳酸化修饰通过调控基因转录、蛋白质表达以及亚细胞定位，参与细胞内的生物学过程。衰老可导致多个器官出现乳酸代谢紊乱。近年来的研究表明，由乳酸代谢紊乱介导的乳酸化修饰参与多种年龄相关疾病的发生与发展。本文对乳酸化修饰在年龄相关疾病中的功能及相关机制进行综述。
Abstract
Lactylation (Kla) is a novel post-translation protein modification regulation mechanism realized by the covalent coupling of lactate generated by glycolysis and lysine residues. Lactylation primarily includes histone Kla and non-histone Kla. Kla participates in biological processes in cells by regulating gene transcription and protein expression, as well as subcellular localization. Multiple organs are exposed to lactate metabolism disorder due to aging. Recent studies have demonstrated that Kla mediated by lactate metabolism disorder is involved in the occurrence and development of various age-related diseases. This article summarizes the functions of Kla in age-related diseases and the related mechanisms.
如何引用
AMA
Pengfei Li, Miaomiao Wu, Linhui Xu, Min Ji, Huaijin Guan. The role of lactylation in age-related diseases: a molecular perspective.. PeerJ. 2026; doi:10.7717/peerj.20957.
APA
Pengfei Li, Miaomiao Wu, Linhui Xu, Min Ji, Huaijin Guan (2026). The role of lactylation in age-related diseases: a molecular perspective.. PeerJ. https://doi.org/10.7717/peerj.20957
GB/T 7714
Pengfei Li, Miaomiao Wu, Linhui Xu, Min Ji, Huaijin Guan. The role of lactylation in age-related diseases: a molecular perspective.[J]. PeerJ, 2026 doi:10.7717/peerj.20957.
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