银屑病是一种全身炎症性疾病：共病和复发的免疫设定点框架
Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.
摘要(中文译文)
银屑病日益被认为是一种超越皮肤炎症的系统性免疫介导疾病。尽管皮肤病变是其最明显的表现，但越来越多的证据表明，银屑病反映了免疫稳态的更广泛破坏，并伴有持续的系统性炎症激活。持续的免疫激活、髓系编程的改变以及免疫代谢通路的失调共同建立了慢性炎症致敏状态。这种系统性炎症状态促进了多器官共病，并通过持久的免疫记忆和训练免疫促进疾病复发。在本综述中，我们提出银屑病反映了系统性免疫设定点的适应不良性重编程，使得空间上的多器官受累和时间上的疾病复发均源于共享的免疫学机制。从这一角度认识银屑病对共病评估、长期维持策略以及追求疾病修饰具有重要意义。
Abstract
Psoriasis is increasingly recognized as a systemic immune-mediated disorder that extends beyond cutaneous inflammation. Although skin lesions are its most visible manifestation, growing evidence indicates that psoriasis reflects a broader disruption of immune homeostasis accompanied by sustained systemic inflammatory activation. Persistent immune activation, altered myeloid programming, and dysregulated immunometabolic pathways together establish a state of chronic inflammatory priming. This systemic inflammatory state contributes to multi-organ comorbidities and also favors disease relapse through durable immune memory and trained immunity. In this review, we propose that psoriasis reflects maladaptive reprogramming of the systemic immune set-point, such that both spatial multi-organ involvement and temporal disease recurrence arise from shared immunologic mechanisms. Viewing psoriasis in these terms has important implications for comorbidity assessment, long-term maintenance strategies, and the pursuit of disease modification.
如何引用
AMA
Jingyi Ma, Haoyu Li, Xueqi Yang, Yuzhe Cheng, Bingran Qi, Siyu Kang, et al. Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1830099.
APA
Jingyi Ma, Haoyu Li, Xueqi Yang, Yuzhe Cheng, Bingran Qi, Siyu Kang, et al (2026). Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1830099
GB/T 7714
Jingyi Ma, Haoyu Li, Xueqi Yang, Yuzhe Cheng, Bingran Qi, Siyu Kang, et al. Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1830099.
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