系统性硬化症脂质代谢轴的重新编程：机制分析和治疗潜力
Reprogramming of the lipid metabolism axis in systemic sclerosis: mechanism analysis and therapeutic potential.
摘要(中文译文)
系统性硬化症（SSc）是一种高度致命的自身免疫性疾病，其特征性病理表现包括微血管损伤、免疫失调以及累及皮肤和多个器官的进行性纤维化。临床上，SSc相关间质性肺病和心血管并发症是导致死亡的主要原因。新兴研究凸显了脂质代谢紊乱在SSc发病机制中的作用，临床观察到的血脂谱异常可能与疾病进展相关。脂质组学的进展阐明了特定脂质种类及其信号通路的病理改变，为SSc代谢重编程提供了新的见解，并识别出潜在的治疗靶点。本综述综合了目前关于SSc患者脂质异常的证据，重点关注血脂异常与三个核心病理过程（血管损伤、免疫功能障碍和纤维化重塑）之间的相互作用。此外，我们简要分析了现有药物干预对SSc患者血脂谱的影响，为开发靶向脂质代谢的疗法以完善临床管理提供基础。
Abstract
Systemic sclerosis (SSc), a highly fatal autoimmune disease, is characterized by pathological hallmarks including microvascular damage, immune dysregulation, and progressive fibrosis affecting the skin and multiple organs. Clinically, SSc-related interstitial lung disease and cardiovascular complications represent the primary causes of mortality. Emerging research has highlighted the role of lipid metabolism dysregulation in SSc pathogenesis, with clinically observed abnormal lipid profiles potentially linked to disease progression. Advances in lipidomics have elucidated pathological alterations in specific lipid species and their signaling pathways, offering novel insights into metabolic reprogramming in SSc and identifying potential therapeutic targets. This review synthesizes current evidence on lipid abnormalities in SSc patients, focusing on the interplay between dyslipidemia and three core pathological processes: vascular injury, immune dysfunction, and fibrotic remodeling. Additionally, we briefly analyze the effects of existing drug interventions on the lipid profile of SSc patients, providing a foundation for developing lipid metabolism-targeted therapies to refine clinical management.
如何引用
AMA
Rong-Hong Guo, Xian-Zhe Zhou, Yan-Li Yang, Jia-Xin Chen, Jin-Fang Gao, Ke Xu. Reprogramming of the lipid metabolism axis in systemic sclerosis: mechanism analysis and therapeutic potential.. Clinical rheumatology. 2026; doi:10.1007/s10067-026-08189-6.
APA
Rong-Hong Guo, Xian-Zhe Zhou, Yan-Li Yang, Jia-Xin Chen, Jin-Fang Gao, Ke Xu (2026). Reprogramming of the lipid metabolism axis in systemic sclerosis: mechanism analysis and therapeutic potential.. Clinical rheumatology. https://doi.org/10.1007/s10067-026-08189-6
GB/T 7714
Rong-Hong Guo, Xian-Zhe Zhou, Yan-Li Yang, Jia-Xin Chen, Jin-Fang Gao, Ke Xu. Reprogramming of the lipid metabolism axis in systemic sclerosis: mechanism analysis and therapeutic potential.[J]. Clinical rheumatology, 2026 doi:10.1007/s10067-026-08189-6.
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