用于止血和MRSA感染伤口愈合的光动力/光热金纳米簇壳聚糖海绵
Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing.
摘要(中文译文)
多重耐药（MDR）细菌，尤其是耐甲氧西林金黄色葡萄球菌（MRSA），阻碍了伤口感染的治疗。需要设计新的策略来有效清除细菌并促进伤口愈合。本研究制备了一种新型壳聚糖基海绵CS-AuNCs/ICG，用于对抗MDR细菌和治疗皮肤伤口。在CS海绵体系中，ICG在光照下可快速产生活性氧（ROS），从而发挥快速杀菌作用；相比之下，从体系中缓慢释放的金纳米簇（AuNCs）可实现持久杀菌效果。在体外，CS-AuNCs/ICG对浮游态MRSA和生物膜均表现出优异的抗菌活性。此外，该海绵不仅具有高效止血性能，还具有高孔隙率的多孔结构，适合吸收伤口渗出液。使用CS-AuNCs/ICG海绵联合光照对MRSA感染小鼠进行局部治疗，可使皮肤伤口中的细菌迅速清除并实现持久抑菌，从而加速伤口愈合，且未观察到任何副作用。总之，CS-AuNCs/ICG海绵兼具高效抗菌活性和持续抑菌能力，在治疗耐药细菌感染伤口方面展现出重要的应用潜力。
Abstract
Multidrug-resistant (MDR) bacteria, particularly methicillin-resistant (MRSA), impede wound infection treatment. Novel strategies shall be designed to effectively eliminate bacteria and facilitate wound recovery. This study fabricated a new chitosan-based sponge, CS-AuNCs/ICG, to combat MDR bacteria and treat skin wounds. In the CS sponge system, ICG can rapidly generate reactive oxygen species (ROS) upon light irradiation, thereby exerting a rapid bactericidal effect; in contrast, the gold nanoclusters (AuNCs) slowly released from the system can achieve a long-lasting bactericidal effect. In vitro, CS-AuNCs/ICG exhibited excellent antibacterial activity against both planktonic MRSA and biofilm. Moreover, this sponge featured not only an efficient hemostatic property but also a high-porosity porous structure ideal for wound exudate absorption. Local remedy of MRSA-infected mice using the CS-AuNCs/ICG sponge combined with light irradiation resulted in prompt bacterial elimination and prolonged bacteriostasis in the skin wounds, which accelerated wound healing without any observed side effects. In summary, the CS-AuNCs/ICG sponge possesses both high-efficiency antibacterial activity and sustained bacterial inhibition ability, demonstrating significant application potential in treating wounds infected with drug-resistant bacteria.
如何引用
AMA
Xiaoyi Shi, Jingqian Su, Wenting Li, Keke Li, Xiangjun Chen, Wei Hong. Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing.. International journal of nanomedicine. 2026; doi:10.2147/IJN.S576313.
APA
Xiaoyi Shi, Jingqian Su, Wenting Li, Keke Li, Xiangjun Chen, Wei Hong (2026). Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing.. International journal of nanomedicine. https://doi.org/10.2147/IJN.S576313
GB/T 7714
Xiaoyi Shi, Jingqian Su, Wenting Li, Keke Li, Xiangjun Chen, Wei Hong. Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing.[J]. International journal of nanomedicine, 2026 doi:10.2147/IJN.S576313.
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