低剂量白细胞介素-2单药治疗后银屑病的快速缓解：病例报告

摘要(中文译文)

银屑病是一种慢性、免疫介导的炎症性疾病。尽管治疗方面已取得显著进展，但仍有相当一部分患者要么未能获得充分应答，要么出现不良反应。本文报告一例有20年银屑病病史、对局部治疗难治的患者。她接受了低剂量白细胞介素-2（IL-2）单药治疗（每日皮下注射50万IU，连续80天）。观察到迅速且显著的临床改善。未报告不良事件，且患者在停止治疗后未见新发皮损。据我们所知，这是首例采用低剂量IL-2单药治疗成功治愈银屑病的病例，提示该方法可能成为银屑病患者一种快速且有效的替代选择。尚需在更大规模的临床研究中进一步评估。

Abstract

Psoriasis is a chronic, immune-mediated inflammatory disease. Despite significant advancements in therapies, a considerable subset of patients either fails to achieve adequate response or experiences adverse effects. Herein, we present the case of a patient with a 20-year history of psoriasis, refractory to topical therapy. She received low-dose interleukin-2 (IL-2) monotherapy (500,000 IU subcutaneously daily for 80 consecutive days). A prompt and marked clinical improvement was noted. No adverse events were reported, and the patient remained free of new lesions after treatment discontinuation. To our knowledge, this is the first case of psoriasis successfully treated with low-dose IL-2 monotherapy, suggesting that this approach may represent a rapid and effective alternative for patients with psoriasis. Further evaluation in larger clinical studies is warranted.

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