一个纠结的故事：2型自身免疫性胰腺炎伴硬化性扭转
A Tangled Tale: Type 2 Autoimmune Pancreatitis With a Sclerosing Twist.
摘要(中文译文)
自身免疫性胰腺炎（AIP）是一种少见的免疫介导性疾病，可模仿胰腺癌，并以梗阻性黄疸为表现。2型AIP不依赖IgG4，常与炎症性肠病相关。我们描述了一名患有克罗恩病的女性，其表现为腹痛、黄疸和胆汁淤积性肝损伤。影像学显示胰头增大和胆道狭窄，令人担忧恶性肿瘤。初次活检和血清学检查无结论，免疫球蛋白亚类4水平正常。内镜超声显示慢性胰腺炎症，皮质类固醇治疗导致显著改善，支持2型AIP并发继发性硬化性胆管炎和3c型糖尿病的诊断。
Abstract
Autoimmune pancreatitis (AIP) is an uncommon immune-mediated condition that can mimic pancreatic cancer and present with obstructive jaundice. Type 2 AIP is IgG4-independent and commonly associated with inflammatory bowel disease. We describe a woman with Crohn's disease who presented with abdominal pain, jaundice, and cholestatic liver injury. Imaging showed pancreatic head enlargement and biliary strictures concerning for malignancy. Initial biopsy and serology were inconclusive with normal immunoglobulin subclass 4 levels. Endoscopic ultrasound demonstrated chronic pancreatic inflammation, and corticosteroid therapy led to marked improvement, supporting a diagnosis of type 2 AIP complicated by secondary sclerosing cholangitis and type 3c diabetes.
如何引用
AMA
Khaled H Husain, Rachael Hagen, Bianca Thakkar, Norbert Promagan, Neil D Parikh. A Tangled Tale: Type 2 Autoimmune Pancreatitis With a Sclerosing Twist.. ACG case reports journal. 2026; doi:10.14309/crj.0000000000002150.
APA
Khaled H Husain, Rachael Hagen, Bianca Thakkar, Norbert Promagan, Neil D Parikh (2026). A Tangled Tale: Type 2 Autoimmune Pancreatitis With a Sclerosing Twist.. ACG case reports journal. https://doi.org/10.14309/crj.0000000000002150
GB/T 7714
Khaled H Husain, Rachael Hagen, Bianca Thakkar, Norbert Promagan, Neil D Parikh. A Tangled Tale: Type 2 Autoimmune Pancreatitis With a Sclerosing Twist.[J]. ACG case reports journal, 2026 doi:10.14309/crj.0000000000002150.
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