胎儿生长受限的动脉和静脉多普勒参数：早期和晚期亚型的比较评估
Arterial and Venous Doppler Parameters in Fetal Growth Restriction: A Comparative Evaluation of Early- and Late-Onset Subtypes.
摘要(中文译文)
评估并比较早发型（EO）与晚发型（LO）胎儿生长受限（FGR）的胎儿动脉及静脉多普勒参数，并评价其在本研究队列中的表现及其与复合不良新生儿结局（CANO）的关联。本前瞻性观察性队列研究纳入184例孕24至37周的单胎妊娠，包括91例FGR病例和93例适龄胎儿对照组。FGR依据Delphi共识标准定义，并分为早发型FGR（<32周）或晚发型FGR（≥32周）。所有胎儿均接受脐动脉（UA）、大脑中动脉（MCA）、子宫动脉（UtA）及静脉导管（DV）的标准化多普勒评估。计算脑胎盘比（CPR）。分别针对早发型FGR和晚发型FGR构建多变量逻辑回归模型。采用受试者工作特征分析评估分类性能。CANO定义为以下至少一项：5分钟Apgar评分<7分、呼吸窘迫综合征、新生儿重症监护病房入住或早产。在早发型FGR和晚发型FGR中，UA PI值均显著升高，而MCA PI和CPR均显著低于对照组。在两个亚组中，CPR在动脉参数中表现出最高的判别性能。早发型FGR中DV多普勒指数无显著差异。在晚发型FGR中，DV S波和v波速度与FGR独立相关。亚组分析中未观察到多普勒参数与CANO之间存在显著关联。动脉多普勒参数，尤其是CPR，在早发型和晚发型FGR中均表现出一致的改变。静脉多普勒参数的贡献因临床亚型而异，在晚发型FGR中观察到额外价值。
Abstract
: To evaluate and compare fetal arterial and venous Doppler parameters in early-onset (EO) and late-onset (LO) fetal growth restriction (FGR), and to assess their performance within the study cohort and their association with composite adverse neonatal outcome (CANO). : This prospective observational cohort study included 184 singleton pregnancies between 24 and 37 weeks of gestation, comprising 91 FGR cases and 93 appropriate-for-gestational-age controls. FGR was defined according to Delphi consensus criteria and classified as EO-FGR (<32 weeks) or LO-FGR (≥32 weeks). All fetuses underwent standardized Doppler assessment of the umbilical artery (UA), middle cerebral artery (MCA), uterine artery (UtA), and ductus venosus (DV). The cerebroplacental ratio (CPR) was calculated. Multivariable logistic regression models were constructed separately for EO-FGR and LO-FGR. Classification performance was evaluated using receiver operating characteristic analysis. CANO was defined as at least one of the following: 5-min Apgar score <7, respiratory distress syndrome, neonatal intensive care unit admission, or preterm birth. : In both EO-FGR and LO-FGR, UA PI values were significantly higher, whereas MCA PI and CPR were significantly lower than in controls. CPR demonstrated the highest discriminative performance among arterial parameters in both subgroups. DV Doppler indices were not significantly different in EO-FGR. In LO-FGR, DV S-wave and v-wave velocities were independently associated with FGR. No significant associations were observed between Doppler parameters and CANO in subgroup analyses. : Arterial Doppler parameters, particularly CPR, showed consistent alterations in both EO- and LO-FGR. The contribution of venous Doppler parameters differed according to clinical subtype, with additional value observed in LO-FGR.
如何引用
AMA
Hale Ankara Aktas, Ilayda Gercik Arzik, Zubeyde Emiralioglu Cakir, Burak Bayraktar, Bahar Konuralp Atakul, Emre Bayram, et al. Arterial and Venous Doppler Parameters in Fetal Growth Restriction: A Comparative Evaluation of Early- and Late-Onset Subtypes.. Diagnostics (Basel, Switzerland). 2026; doi:10.3390/diagnostics16101488.
APA
Hale Ankara Aktas, Ilayda Gercik Arzik, Zubeyde Emiralioglu Cakir, Burak Bayraktar, Bahar Konuralp Atakul, Emre Bayram, et al (2026). Arterial and Venous Doppler Parameters in Fetal Growth Restriction: A Comparative Evaluation of Early- and Late-Onset Subtypes.. Diagnostics (Basel, Switzerland). https://doi.org/10.3390/diagnostics16101488
GB/T 7714
Hale Ankara Aktas, Ilayda Gercik Arzik, Zubeyde Emiralioglu Cakir, Burak Bayraktar, Bahar Konuralp Atakul, Emre Bayram, et al. Arterial and Venous Doppler Parameters in Fetal Growth Restriction: A Comparative Evaluation of Early- and Late-Onset Subtypes.[J]. Diagnostics (Basel, Switzerland), 2026 doi:10.3390/diagnostics16101488.
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