重塑ME/CFS：迈向慢性感染后疾病的统一机制模型
Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.
摘要(中文译文)
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种严重的多系统疾病，以劳力后不适（PEM）、认知功能障碍、自主神经紊乱和生理恢复力受损为特征。历史上，由于缺乏经过验证的生物标志物、定义异质性以及研究能力有限，机制阐释变得复杂，并促使临床实践和部分文献中采用心理社会和康复框架。系统生物学的进展，在长新冠研究的推动下加速发展，已改变了我们对感染后综合征的理解，涉及持续性免疫失调、线粒体和代谢重编程、内皮和微血管功能障碍、凝血异常、脂质介导的信号传导、细胞外囊泡通讯以及病毒蛋白相关免疫激活。本综述描绘了从早期感染后观察到心理社会主导地位再到当代生物学框架的转变，强调病理是状态依赖性的，并在生理应激下显现。因此，ME/CFS在此被重新定义为感染后疾病生物学中适应能力受损的一种障碍。
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem illness marked by post-exertional malaise (PEM), cognitive dysfunction, autonomic disturbance, and impaired physiological resilience. Historically, the absence of validated biomarkers, heterogeneous definitions, and limited investigative capacity have complicated mechanistic interpretation and contributed to the use of psychosocial and rehabilitative frameworks in clinical practice and in parts of the literature. Advances in systems biology, accelerated by Long-COVID research, have transformed our understanding of post-infectious syndromes, implicating persistent immune dysregulation, mitochondrial and metabolic reprogramming, endothelial and microvascular dysfunction, abnormal coagulation, lipid-mediated signalling, extracellular vesicle communication, and viral protein-associated immune activation. This review charts the shift from early post-infectious observations through psychosocial dominance to contemporary biological frameworks, emphasising that pathology is state-dependent and revealed under physiological stress. ME/CFS is thus reframed here as a disorder of impaired adaptive capacity within post-infectious disease biology.
如何引用
AMA
Paul Watton, Bhupesh K Prusty. Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.. Journal of translational medicine. 2026; doi:10.1186/s12967-026-08319-3.
APA
Paul Watton, Bhupesh K Prusty (2026). Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.. Journal of translational medicine. https://doi.org/10.1186/s12967-026-08319-3
GB/T 7714
Paul Watton, Bhupesh K Prusty. Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.[J]. Journal of translational medicine, 2026 doi:10.1186/s12967-026-08319-3.
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