织物增强仿生细胞迁移高速公路：微孔引导和血管无细胞基质调节，用于原位血管修复
Fabric-reinforced biomimetic cell migration highway: Micropore guidance and vascular acellular matrix regulation for in situ vascular repair.
摘要(中文译文)
传统的基于水凝胶的血管移植物经常失败，因为它们缺乏机械强度，并且其致密的结构限制了细胞浸润。为了克服这些挑战，我们制备了一种双层织物增强复合血管移植物，该移植物将良好的机械性能与生物活性相结合。内层由水凝胶基质与血管无细胞基质（VAM）颗粒和牺牲明胶微球混合而成，形成相互连接的仿生微通道网络，作为“细胞高速公路”，引导和增强细胞迁移和组织再生。外层针织聚乳酸（PLA）网提供了相当大的机械强度，并改善了缝合线的保持，从而克服了水凝胶固有的机械限制。在兔颈动脉模型中植入3个月后，移植物重塑为类似天然血管的三层结构，显示出100%的通畅性以及机械强度和生物功能的有效结合。这种方法解决了传统水凝胶血管移植物的主要局限性，并为小直径血管移植物开发提供了一种有前景的策略。意义陈述：传统的水凝胶血管移植物受到机械强度差和细胞浸润受限的困扰。我们设计了一种双层织物增强移植物：其内部水凝胶VAM基质嵌入牺牲明胶微球，形成相互连接的微通道，作为细胞迁移的“细胞高速公路”；外层针织PLA网增强了机械强度和缝合线保持力。兔颈动脉植入术在3个月时实现了100%的通畅性和天然血管样三层重塑。这种可扩展的策略解决了机械-生物权衡问题，推进了血管组织工程，并吸引了专注于生物材料临床翻译的读者。
Abstract
Conventional hydrogel-based vascular grafts often fail because they lack mechanical strength, and their dense structure restricts cell infiltration. To overcome these challenges, we fabricated a bilayer fabric-reinforced composite vascular graft that integrates favorable mechanical properties with biological activity. The inner layer is composed of a hydrogel matrix mixed with vascular acellular matrix (VAM) particles and sacrificial gelatin microspheres, forming an interconnected biomimetic microchannel network that serves as a "cellular highway" to guide and enhance cell migration and tissue regeneration. The outer knitted polylactic acid (PLA) mesh provides substantial mechanical strength and improves suture retention, thereby overcoming the inherent mechanical limitations of hydrogels. After implantation in a rabbit carotid artery model for 3 months, the graft remodeled into a three-layered structure resembling native vessels, demonstrating 100% patency and an effective combination of mechanical strength and biological functionality. This approach addresses key limitations of conventional hydrogel-based vascular grafts and offers a promising strategy for the development of small-diameter vascular grafts. STATEMENT OF SIGNIFICANCE: Conventional hydrogel vascular grafts are plagued by poor mechanical strength and restricted cell infiltration. We engineered a bilayer fabric-reinforced graft: its inner hydrogel-VAM matrix, embedded with sacrificial gelatin microspheres, forms interconnected microchannels as a "cellular highway" for cell migration; the outer knitted PLA mesh enhances mechanical strength and suture retention. Rabbit carotid implantation achieved 100% patency and native vessel-like three-layer remodeling at 3 months. This scalable strategy resolves the mechanical-biological trade-off, advancing vascular tissue engineering and appealing to readers focused on biomaterial clinical translation.
如何引用
AMA
Linlin Guo, Qi Huang, Chao Xu, Xianzhen Dong, Yuyi Tian, Yawen Shi, et al. Fabric-reinforced biomimetic cell migration highway: Micropore guidance and vascular acellular matrix regulation for in situ vascular repair.. Acta biomaterialia. 2026; doi:10.1016/j.actbio.2026.05.033.
APA
Linlin Guo, Qi Huang, Chao Xu, Xianzhen Dong, Yuyi Tian, Yawen Shi, et al (2026). Fabric-reinforced biomimetic cell migration highway: Micropore guidance and vascular acellular matrix regulation for in situ vascular repair.. Acta biomaterialia. https://doi.org/10.1016/j.actbio.2026.05.033
GB/T 7714
Linlin Guo, Qi Huang, Chao Xu, Xianzhen Dong, Yuyi Tian, Yawen Shi, et al. Fabric-reinforced biomimetic cell migration highway: Micropore guidance and vascular acellular matrix regulation for in situ vascular repair.[J]. Acta biomaterialia, 2026 doi:10.1016/j.actbio.2026.05.033.
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